Effects of postnatal stress on dopamine mesolimbic system responses to aversive experiences in adult life

Cabib, Simona; Puglisi-Allegra, Stefano; D’Amato, Francesca R.

doi:10.1016/0006-8993(93)90374-v

Cited by 55 publications

(41 citation statements)

References 36 publications

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“…CB and SM pups showed an enhanced behavioral sensitivity to the DA agonist apomorphine compared with controls 24 hr after the last manipulation. Studies conducted in our laboratory have shown short-and long-term effects of postnatal manipulation on apomorphine-induced wall-climbing behavior in 15-day-old and 3-month-old male mice (Cabib et al, 1993;D'Amato & Cabib, 1987). Moreover, the stressinduced dopamine release in the nucleus accumbens of postnatally handled adult mice was significantly lower in comparison to nonhandled conspecifics (Cabib et al, 1993).…”

Section: Discussionmentioning

confidence: 95%

“…Altogether, these studies support the hypothesis that this procedure elicits a stress response. In adulthood, these animals displayed reduced emotionality levels (measured in the elevated plus-maze) and a decreased response of the dopaminergic system to repeated restraint (Cabib, Puglisi-Allegra, & D'Amato, 1993). Moreover, they had a higher pain threshold level and showed a reduction in the behavioral response to the analgesic effect of morphine (D'Amato, Mazzacane, Capone, & Pavone, 1999).…”

Section: Introductionmentioning

confidence: 98%

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Postnatal stress in mice: Does “stressing” the mother have the same effect as “stressing” the pups?

Moles¹,

Rizzi²,

D’Amato³

2004

Developmental Psychobiology

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Short- and long-term effects of brief maternal separation, maternal exposure to novel male odor, and standard rearing were compared in NMRI mice. The first condition consisted of 15 min of daily exposure of pups to clean bedding (CB), and the second condition consisted of 15 min of mothers' exposure to the odor of strange males (SM), for 14 days after birth starting from postnatal Day 1. Thus, both conditions entailed the same period of maternal separation. A control mother-offspring group was left undisturbed (nonhandled, N-H). Corticosterone levels of mothers and pups were measured at the end of the last manipulation session. Corticosterone levels were higher in SM mothers, differing from both those of CB and of control dams; CB pups showed the highest corticosterone levels in comparison with the pups belonging to the other groups. Maternal behavior observed as furthest as possible from the daily separation session did not differ among the three groups. The behavioral response to 0.5 mg/kg of apomorphine in 15-day-old pups was enhanced in both CB and SM animals, which suggests an alteration of dopaminergic functioning. Finally, adult CB and SM male mice showed an increase in the percentage of time and entries into the open arms of the plus-maze in comparison to nonhandled males. This study indicates that exposure to ecologically relevant stimuli elicited a stress response in lactating dams. This "social stress" brings about short- and long-term effects in the offspring, even in the absence of any direct manipulation of the pups.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 98%

Postnatal stress in mice: Does “stressing” the mother have the same effect as “stressing” the pups?

Moles¹,

Rizzi²,

D’Amato³

2004

Developmental Psychobiology

View full text Add to dashboard Cite

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“…Like the LHPA axis, this system undergoes significant developmental changes postnatally (Cabib et al, 1993;Gariepy et al, 2002;Kehoe et al, 1998a). Few studies have examined the interaction between early life events, LHPA reactivity, and the dopaminergic system.…”

Section: Discussionmentioning

confidence: 99%

Manipulations During the Second, but not the First, Week of Life Increase Susceptibility to Cocaine Self-Administration in Female Rats

Flagel

Vázquez

Robinson

2003

Neuropsychopharmacol

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We compared the effects of manipulations during week 1 vs week 2 of life on the propensity to self-administer cocaine. Pups received daily subcutaneous saline injections, were handled briefly, or remained undisturbed during their respective treatment periods. Animals handled during the second week of life exhibited increased locomotor response to novelty when tested on postnatal day (PND) 48, compared to all other groups. Rats were implanted with jugular catheters on PND 70 and then given the opportunity to self-administer (0.125 mg/kg/infusion) cocaine for 5 consecutive days (1 h sessions). The dose was then raised to 0.25 mg/kg/infusion for 5 days and to 0.5 mg/kg/infusion for the final 5 days of testing. Only animals manipulated during the second week of life acquired drug-taking behavior. These effects were both stimulus-and gender-specific. Females handled during the second week of life acquired cocaine selfadministration (SA) at the lowest dose, and females injected during the second week of life acquired at the intermediate dose. Males injected during the second week of life showed a similar, but more variable, drug-taking pattern. There were no group differences in serum corticosterone response to novelty, although relative to undisturbed animals and those manipulated in the first week of life, female animals manipulated during the second week of life had lower basal expression of hippocampal glucocorticoid receptor mRNA in adulthood. We conclude that the second week of life in the rodent is a sensitive period during which manipulations result in a more vulnerable phenotype for the acquisition of cocaine SA.

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“…When neonatal lesions of the VTA are performed, it is found that even moderate lesions of the DA system may alter the normal hormonal response to stress, indicating that the dopaminergic system may have a direct influence on the HPA axis. 64 The fact that in laboratory animals the effect of early stressful experiences on brain DA functioning may not be evident in basal conditions, but can only be revealed under environmental pressure which evokes anxiety and/or fear, 65 has suggested a possible role for other transmitter systems which may give an 'emotional connotation' to stress.…”

Section: Stress Dopamine and Other Neurotransmitters (The Gates For mentioning

confidence: 99%

The role of stress in the pathophysiology of the dopaminergic system

2000

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In this review, we will examine the most recent preclinical evidence in support of the fact that both acute and chronic stress may have a detrimental impact on the normal function of the dopaminergic system. In recent decades, the term stress has changed its meaning from that of a 'non-specific body response' to a 'monitoring system of internal and external cues'; that is a modality of reaction of the mammalian central nervous system (CNS) which is critical to the adaptation of the organism to its environment. Compelling results have demonstrated that the dopaminergic system is important not only for hedonic impact or reward learning but also, in a broader sense, for reactivity to perturbation in environmental conditions, for selective information processing, and for general emotional responses, which are essential functions in the ability (or failure) to cope with the external world. In this, stress directly influences several basic behaviors which are mediated by the dopaminergic system such as locomotor activity, sexual activity, appetite, and cross sensitization with drugs of abuse. Studies using rat lines which are genetically different in dopamine (DA) physiology, have shown that even small alterations in the birth procedure or early life stress events may contribute to the pathophysiology of psychiatric disorders-in particular those involving central DA dysfunctionand may cause depression or psychotic derangement in the offspring. Finally, the fact that the dopaminergic system after stress responds, preferentially, in the medial prefrontal cortex (MFC), is thought to serve, in humans, as a protection against positive psychotic symptoms, since the increased DA activity in the MFC suppresses limbic DA transmission. However, excessive MFC dopaminergic activity has a negative impact on the cognitive functions of primates, making them unable to select and process significant environmental stimuli. Thus it appears that a critical range of DA turnover is necessary for optimal cognitive functioning after stress, in the response of the CNS to ever-changing environmental demands. Molecular Psychiatry (2000) 5, 14-21.

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Effects of postnatal stress on dopamine mesolimbic system responses to aversive experiences in adult life

Cited by 55 publications

References 36 publications

Postnatal stress in mice: Does “stressing” the mother have the same effect as “stressing” the pups?

Postnatal stress in mice: Does “stressing” the mother have the same effect as “stressing” the pups?

Manipulations During the Second, but not the First, Week of Life Increase Susceptibility to Cocaine Self-Administration in Female Rats

The role of stress in the pathophysiology of the dopaminergic system

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