Effects of postnatal progesterone treatment on ovarian function in adult rats

Bukovský, Antonín; Presl, J; Krabec, Z

doi:10.1007/bf01922773

Cited by 11 publications

(7 citation statements)

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“…This effect is even more pronounced at doses of MPA 5-20 times higher than those received via milk. This agrees well with earlier observations (Shapiro et al 1976;Bukovsky et al 1979;L. .…”

Section: Resultssupporting

confidence: 93%

“…Secondly, exposure to progestins perinatally and/or neonatally can have long-lasting effects, including changes in adult sexual behaviour (Hull, Franz, Snyder & Nishita, 1980) and in genital morphology (Revez, Chapel & Gaudry, 1960;Holzhausen, 1982) and can lead to acyclicity as defined by vaginal cytology in the female rat (Shapiro, Goldman, Bongiovanni & Marino, 1976;Bukovsky, Presi & Krabec, 1979). Thirdly, it has been reported that neonatal male and female rats differ in the level of circulating progestins (Shapiro et al 1976; C. Holzhausen, unpublished observations; but see Weisz & Ward, 1980, for conflicting results).…”

Section: Introductionmentioning

confidence: 93%

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Neonatal exposure to a progestin via milk alters subsequent LH cyclicity in the female rat

Holzhausen

Murphy

Birke

1984

Journal of Endocrinology

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Medroxyprogesterone acetate (MPA; 5 micrograms/g body wt) or norethisterone oenanthate (NET-OEN; 4 micrograms/g body wt) was given to lactating female rats by subcutaneous injection 1 day after parturition. Each female suckled ten female pups which had been randomly allocated to her and at 21 days of age the pups were weaned. In this way female pups were exposed to either MPA or NET-OEN via milk during suckling. The patterns of LH and progesterone secretion at pro-oestrus were investigated using radioimmunoassay. When these pups reached adulthood it was found that neonatal exposure to MPA via milk significantly reduced the pro-oestrous LH peak by 45% as well as the total amount (by 27%) of LH secreted during pro-oestrus. Neonatal exposure via milk to NET-OEN had no effect on LH secretion during pro-oestrus. Pro-oestrous progesterone secretion was unaffected by either MPA or NET-OEN treatment.

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“…This effect is even more pronounced at doses of MPA 5-20 times higher than those received via milk. This agrees well with earlier observations (Shapiro et al 1976;Bukovsky et al 1979;L. .…”

Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 93%

Neonatal exposure to a progestin via milk alters subsequent LH cyclicity in the female rat

Holzhausen

Murphy

Birke

1984

Journal of Endocrinology

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“…Our studies in the late 1970s [23,24,59,60] and 1980s [61,62] resulted in the proposal of a wider role of the immune system (immune cells and vascular pericytes), the so-called tissue control system (TCS), in regulation of ovarian function [29]. The TCS theory was further refined when the role of autonomic innervation in the regulation of "quantitative aspects in tissues," including follicular selection, was added [63,64], and the TCS theory was revised [65,66].…”

Section: Immune System and Tissue Homeostasis (Tissue Immune Physimentioning

confidence: 99%

Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial

Bukovský

Caudle

2012

Reprod Biol Endocrinol

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The immune system plays an important role in the regulation of tissue homeostasis ("tissue immune physiology"). Function of distinct tissues during adulthood, including the ovary, requires (1) Renewal from stem cells, (2) Preservation of tissue-specific cells in a proper differentiated state, which differs among distinct tissues, and (3) Regulation of tissue quantity. Such morphostasis can be executed by the tissue control system, consisting of immune system-related components, vascular pericytes, and autonomic innervation. Morphostasis is established epigenetically, during morphogenetic (developmental) immune adaptation, i.e., during the critical developmental period. Subsequently, the tissues are maintained in a state of differentiation reached during the adaptation by a “stop effect” of resident and self renewing monocyte-derived cells. The later normal tissue is programmed to emerge (e.g., late emergence of ovarian granulosa cells), the earlier its function ceases. Alteration of certain tissue differentiation during the critical developmental period causes persistent alteration of that tissue function, including premature ovarian failure (POF) and primary amenorrhea. In fetal and adult human ovaries the ovarian surface epithelium cells called ovarian stem cells (OSC) are bipotent stem cells for the formation of ovarian germ and granulosa cells. Recently termed oogonial stem cells are, in reality, not stem but already germ cells which have the ability to divide. Immune system-related cells and molecules accompany asymmetric division of OSC resulting in the emergence of secondary germ cells, symmetric division, and migration of secondary germ cells, formation of new granulosa cells and fetal and adult primordial follicles (follicular renewal), and selection and growth of primary/preantral, and dominant follicles. The number of selected follicles during each ovarian cycle is determined by autonomic innervation. Morphostasis is altered with advancing age, due to degenerative changes of the immune system. This causes cessation of oocyte and follicular renewal at 38 +/-2 years of age due to the lack of formation of new granulosa cells. Oocytes in primordial follicles persisting after the end of the prime reproductive period accumulate genetic alterations resulting in an exponentially growing incidence of fetal trisomies and other genetic abnormalities with advanced maternal age. The secondary germ cells also develop in the OSC cultures derived from POF and aging ovaries. In vitro conditions are free of immune mechanisms, which prevent neo-oogenesis in vivo. Such germ cells are capable of differentiating in vitro into functional oocytes. This may provide fresh oocytes and genetically related children to women lacking the ability to produce their own follicular oocytes. Further study of "immune physiology" may help us to better understand ovarian physiology and pathology, including ovarian infertility caused by POF or by a lack of ovarian follicles with functional oocytes in aging ovaries. The observations indicating...

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“…The original articles give more detailed data and discussion, as well as descriptions of immunohistochemical techniques employed. Although our studies on the rat ovarian model represent an important part of our work, e.g., (Bukovsky et al, 1977(Bukovsky et al, , 1979(Bukovsky et al, , 1981(Bukovsky et al, , 1983(Bukovsky et al, , 1984(Bukovsky et al, , 1993(Bukovsky et al, , 2000a, the aim of this review is to summarize and expand immunohistochemical observations carried out in human ovaries. Fig.…”

Section: Observationsmentioning

confidence: 99%

“…Our studies in the late 1970s (Bukovsky et al, 1977(Bukovsky et al, , 1978(Bukovsky et al, , 1979 and early 1980s (Bukovsky et al, 1981(Bukovsky et al, , 1982 resulted in the concept of a wider role of the immune system (immune cells and vascular pericytes), the so called Tissue Control System (TCS), in regulation of ovarian function (Bukovsky et al, 1983). The TCS theory was further refined when the role of autonomic innervation in the regulation of ''quantitative aspects in tissues,'' including follicular selection, was added (Bukovsky et al, 1991(Bukovsky et al, , 1995a, and the TCS theory was revised Bukovsky et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Immune system involvement in the regulation of ovarian function and augmentation of cancer

Bukovský

2006

Microscopy Res & Technique

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Increasing evidence indicates a role for the immune system and mesenchymal-epithelial interactions in the regulation of ovarian function. Cytokines produced by mesenchymal cells can stimulate development and regression of ovarian structures. We report here that mesenchymal cells releasing surface molecules among epithelial cells--namely vascular pericytes and monocyte-derived cells (MDC)--and intraepithelial T lymphocytes are associated with oogenesis and formation of new primary follicles in both fetal and adult human ovaries. These activated mesenchymal cells interact with the ovarian surface epithelium, which appears to be a source of secondary germ cells and granulosa cells. Activated pericytes and MDC are also associated with stimulation of thecal development during selection of growing secondary follicles from the cohort of primary follicles. However, survival of the dominant follicle during mid-follicular phase selection is associated with a lack of activity of mesenchymal cells and retardation of thecal development, since immature granulosa cells lacking aromatase are unable to resist high levels of thecal androgens. Once the selected follicle matures (late follicular phase), it shows enhanced activity of thecal mesenchymal cells and advanced thecal development. Corpus luteum (CL) development is accompanied by a high activity of vascular pericytes and MDC. In mature CL and CL of pregnancy, luteal MDC and pericytes show a stable (inactive) state. Regression of the CL is associated with regression of pericytes, transformation of MDC into dendritic cells, infiltration by T lymphocytes, and binding of immunoglobulin G to the luteal cells. The immunoglobulin M (IgM) binds to young but not mature luteal cells. In the CL of pregnancy, IgM binds to luteal vessels, but not to luteal cells. Regressing CL shows IgM binding to both luteal cells and vessels. In ovarian cancers, highly activated MDC and sometimes activated pericytes (poorly differentiated carcinomas) are present. IgM binding is similar to that seen in the CL of pregnancy. These data indicate that vascular pericytes, MDC, T cells, and immunoglobulins may play an important role in the regulation of ovarian physiology and contribute to the augmentation of ovarian cancer growth.

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Effects of postnatal progesterone treatment on ovarian function in adult rats

Cited by 11 publications

References 1 publication

Neonatal exposure to a progestin via milk alters subsequent LH cyclicity in the female rat

Neonatal exposure to a progestin via milk alters subsequent LH cyclicity in the female rat

Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial

Immune system involvement in the regulation of ovarian function and augmentation of cancer

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