Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

Moridi, Heresh; Sarihi, Abdolrahman; Habibitabar, Elahe; Shateri, Hossein; Salehi, Iraj; Komaki‬, Alireza; Karimi, Jamshid; Karimi, Seyed Asaad

doi:10.1016/j.ibror.2020.09.001

Cited by 10 publications

(8 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ability to retrieve consolidated memory determines the memory performance during the probe test [ 47 ], which is hippocampal-dependent [ 48 ]. Reduction of hippocampal LTP is usually correlated with impaired spatial memory [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Lack of the peroxiredoxin 6 gene causes impaired spatial memory and abnormal synaptic plasticity

et al. 2021

View full text Add to dashboard Cite

Peroxiredoxin 6 (PRDX6) is expressed dominantly in the astrocytes and exerts either neuroprotective or neurotoxic effects in the brain. Although PRDX6 can modulate several signaling cascades involving cognitive functions, its physiological role in spatial memory has not been investigated yet. This study aims to explore the function of the Prdx6 gene in spatial memory formation and synaptic plasticity. We first tested Prdx6−/− mice on a Morris water maze task and found that their memory performance was defective, along with reduced long-term potentiation (LTP) in CA3-CA1 hippocampal synapses recorded from hippocampal sections of home-caged mice. Surprisingly, after the probe test, these knockout mice exhibited elevated hippocampal LTP, higher phosphorylated ERK1/2 level, and decreased reactive astrocyte markers. We further reduced ERK1/2 phosphorylation by administering MEK inhibitor, U0126, into Prdx6−/− mice before the probe test, which reversed their spatial memory deficit. This study is the first one to report the role of PRDX6 in spatial memory and synaptic plasticity. Our results revealed that PRDX6 is necessary for maintaining spatial memory by modulating ERK1/2 phosphorylation and astrocyte activation. Graphic Abstract

show abstract

Section: Discussionmentioning

confidence: 99%

Lack of the peroxiredoxin 6 gene causes impaired spatial memory and abnormal synaptic plasticity

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The MWM test, a hippocampal-dependent test, is used to assess spatial learning and memory in rodents [ 75 – 78 ]. The main advantage of MWM task is the distinction between spatial conditions (hidden platform) and non-spatial conditions (visible platform).…”

Section: Methodsmentioning

confidence: 99%

Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background Recent studies show that gender may have a significant impact on brain functions. However, the reports of sex effects on spatial ability and synaptic plasticity in rodents are divergent and controversial. Here spatial learning and memory was measured in male and female rats by using Morris water maze (MWM) task. Moreover, to assess sex difference in hippocampal synaptic plasticity we examined hippocampal long-term potentiation (LTP) at perforant pathway-dentate gyrus (PP-DG) synapses. Results In MWM task, male rats outperformed female rats, as they had significantly shorter swim distance and escape latency to find the hidden platform during training days. During spatial reference memory test, female rats spent less time and traveled less distance in the target zone. Male rats also had larger LTP at PP-DG synapses, which was evident in the high magnitude of population spike (PS) potentiation and the field excitatory post synaptic potentials (fEPSP) slope. Conclusions Taken together, our results suggest that sex differences in the LTP at PP-DG synapses, possibly contribute to the observed sex difference in spatial learning and memory.

show abstract

“…In line with this, agonism of group II mGluR (mGluR2/3) impaired SLM in mice, while antagonism of mGluR2/3 [113,115] and the knockout of mGluR2 [114,116] improved and had no effect on SLM, respectively. Despite studies using drugs that affect both group II mGluR, the mGluR2 is predominantly expressed in HIP pyramidal neurons and is likely the receptor subtype mediating these effects [117].…”

Section: Discussionmentioning

confidence: 67%

Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats

McCallum,

Theriault,

Manduca

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Major depressive disorder (MDD) is a recurring affective disorder that is two times more prevalent in females than males. Evidence supports immune system dysfunction as a major contributing factor to MDD, notably in a sexually dimorphic manner. Nuclear factor erythroid 2-related factor 2 (Nrf2), a regulator of antioxidant signaling during inflammation, is dysregulated in many chronic inflammatory disorders, however its role in depression and the associated sex differences have yet to be explored. Here we investigated the sex-specific antidepressant and immunomodulatory effects of the potent Nrf2 activator dimethyl fumarate (DMF), as well as the associated gene expression profiles. Methods Male and female rats were treated with vehicle or DMF (25 mg/kg) while subjected to 8 weeks of chronic unpredictable stress. The effect of DMF treatment on stress-induced depression- and anxiety-like behaviours, as well as deficits in recognition and spatial learning and memory were then assessed. Sex differences in hippocampal (HIP) microglial activation and gene expression response were also evaluated. Results DMF treatment during stress exposure had antidepressant effects in male but not female rats, with no anxiolytic effects in either sex. Recognition learning and memory and spatial learning and memory were impaired in chronically stressed males and females, respectively, and DMF treatment rescued these deficits. DMF treatment also prevented stress-induced HIP microglial activation in males. Conversely, females displayed no HIP microglial activation associated with stress exposure. Lastly, chronic stress elicited sex-specific alterations in HIP gene expression, many of which were normalized in animals treated with DMF. Of note, most of the differentially expressed genes in males normalized by DMF were related to antioxidant, inflammatory or immune responses. Conclusions Collectively, these findings support a greater role of immune processes in males than females in a rodent model of depression. This suggests that pharmacotherapies that target Nrf2 have the potential to be an effective sex-specific treatment for depression.

show abstract

Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

Cited by 10 publications

References 41 publications

Lack of the peroxiredoxin 6 gene causes impaired spatial memory and abnormal synaptic plasticity

Lack of the peroxiredoxin 6 gene causes impaired spatial memory and abnormal synaptic plasticity

Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats

Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats

Contact Info

Product

Resources

About