We analyze the prospects for observing CPT violation using neutralmeson P 0 -P 0 systems. Before one can claim a measurement of CPT violation, one must be able to rule out the possibility that its result is due to simpler new-physics effects. In particular, one must be able to separate the CPT-violating quantities from parameters violating the ∆P = ∆Q rule of semileptonic decays, and from new-physics contributions to the production mechanism of the neutral mesons. One can isolate CPT violation using the semileptonic decays of single, tagged neutral mesons; unfortunately, this situation cannot be implemented at the Υ(4S). For P 0 P 0 pairs produced in a correlated parity-odd state we show that, by combining the di-lepton with the single-lepton decays, it is in principle possible to extract unambiguously one CPT-violating parameter. Finally, we develop the formalism necessary for describing new-physics effects in the production mechanism; this includes both cascade decays and violations of the rule of associated production.