Effects of positive blood alcohol concentration on outcome and systemic interleukin-6 in major trauma patients

Relja, Borna; Menke, James A.; Wagner, Nils; Auner, B.; Voth, M.; Nau, Christoph; Marzi, Ingo

doi:10.1016/j.injury.2016.01.016

Cited by 39 publications

(40 citation statements)

References 36 publications

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“…Exposing monocytes to acute alcohol (25-100 mM) impaired TNF-α, IL-6 and IL-1β production but elevated IL-10 levels in vitro [17, 45]. Additionally, clinical studies revealed acute alcohol use to decrease post-traumatic cytokine levels in trauma patients [8, 16]. …”

Section: Discussionmentioning

confidence: 99%

“…Even more, lower mortality rates in TBI patients with low and moderate blood alcohol concentrations (BAC) were reported [54, 55]. Interestingly, positive BAC has been associated with lower leukocyte counts as well as systemic IL-6 levels in severe TBI or in major trauma patients [8, 16]. However, contradictory data showing deteriorating effects of an alcohol intoxication also on patients´ outcome have been reported as well [43, 56, 57].…”

Section: Discussionmentioning

confidence: 99%

“…In several in vivo models and in clinical trials, acute alcohol use has been described to significantly impact the immune response by suppressing the production of pro-inflammatory mediators such as tumor necrosis factor (TNF)-α, IL-1β or IL-6 [14-16]. In severely injured TP, we found significantly lower leukocyte numbers as well as lower systemic IL-6 levels in patients with positive BAC (>0.5‰) compared with patients with BAC levels below <0.05‰ [8]. Szabo et al described significantly reduced TNF-α and IL-1β release from human blood monocytes in an ex vivo model of bacterial stimulation by acute exposure to alcohol [17].…”

Section: Introductionmentioning

confidence: 87%

“…Next to increasing the risk of injuries, alcohol use is associated with altered inflammatory response upon trauma. While chronic alcohol use was shown to correlate with negative outcomes, acute alcohol use has been demonstrated to positively influence the post-injury clinical course, or to have no effects on diverse outcome parameters in trauma patients [7, 8]. Notably in alcohol-intoxicated TBI patients lower incidence of early coagulopathy, pneumonia and mortality were reported [9, 10].…”

Section: Introductionmentioning

confidence: 99%

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Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway

Mörs¹,

Hörauf²,

Kany³

et al. 2017

Cell Physiol Biochem

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Background/Aims: Alcohol (ethanol, EtOH) as significant contributor to traumatic injury is linked to suppressed inflammatory response, thereby influencing clinical outcomes. Alcohol-induced immune-suppression during acute inflammation (trauma) was linked to nuclear factor-kappaB (NF-ĸB). Here, we analyzed alcohol`s effects and mechanisms underlying its influence on NF-ĸB-signaling during acute inflammation in human lung epithelial cells. Methods: A549-cells were stimulated with interleukin (IL)-1β, or sera from trauma patients (TP) or healthy volunteers, with positive/negative blood alcohol concentrations (BAC), and subsequently exposed to EtOH (170 Mm, 1h). IL-6-release and neutrophil adhesion to A549 were analyzed. Specific siRNA-NIK mediated downregulation of non-canonical, and IKK-NBD-inhibition of canonical NF-ĸB signaling were performed. Nuclear levels of activated p50 and p52 NF-ĸB-subunits were detected using TransAm ELISA. Results: Both stimuli significantly induced IL-6-release (39.79±4.70 vs. 0.58±0.8 pg/ml) and neutrophil adhesion (132.30±8.80 vs. 100% control, p<0.05) to A549-cells. EtOH significantly decreased IL-6-release (22.90±5.40, p<0.05) and neutrophil adherence vs. controls (105.40±14.5%, p<0.05). IL-1β-induced significant activation of canonical/p50 and non-canonical/p52 pathways. EtOH significantly reduced p50 (34.90±23.70 vs. 197.70±36.43, p<0.05) not p52 activation. Inhibition of canonical pathway was further increased by EtOH (less p50-activation), while p52 remained unaltered. Inhibition of non-canonical pathway was unchanged by EtOH. Conclusion: Here, alcohol`s anti-inflammatory effects are mediated via decreasing nuclear levels of activated p50-subunit and canonical NF-ĸB signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway

Mörs¹,

Hörauf²,

Kany³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

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“…występowanie zawrotów głowy predysponuje do upadków, a one zwiększają prawdopodobieństwo powstania urazów. Wpływ alkoholu na urazowość został rów-nież potwierdzony przez liczne badania naukowe [3,4,5,6,7]. Inne zaś czynniki są różnie oceniane przez naukowców.…”

Section: Wstępunclassified

Czynniki wpływające na urazowość narządu ruchu na podstawie danych zebranych od pacjentów zaopatrywanych ambulatoryjnie na Szpitalnym Oddziale Ratunkowym Samodzielnego Publicznego Szpitala Klinicznego nr 1 i hospitalizowanych w Klinice Ortopedii Pomorskiego Uniwersytetu Medycznego w Szczecinie – badanie prospektywne

Pytlak

2018

Pomeranian J Life Sci

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Introduction: Some contributory factors are commonly known. If a person suffers from dizziness, for example, they will be more likely to lose balance and fall, which, in turn, leads to trauma. The influence of alcohol consumption on the incidence of injury has also been well documented in numerous studies. Other relevant factors, however, have received various assessments and recognition by different researchers. There is some disagreement among scientists concerning obesity. The aim of the thesis was to determine the influence of various factors on the incidence of injury. Materials and methods:The subjects used for the study were 800 patients receiving emergency treatment in the emergency department and hospitalised in the Department of Orthopaedics, Traumatology and Locomotor Oncology, Pomeranian Medical University in Szczecin (in Poland). The diagnostic survey method was employed. Results: Within the study group women were found to have a higher incidence of contusion. During a snowfall they also proved to suffer physical trauma more often than men. Men, on the other hand, displayed a higher incidence of injury at work. They were also more likely to suffer from torso injury. Younger individuals were more tired at the time of the accident than their older counterparts. Those having more sleep suffered fewer bone fractures. Conclusions: 1. The research showed that the group with the highest risk of trauma were women aged above 46 and suffering from hypertension. In contrast, for men the risk was highest among working individuals aged under 30. 2. Those with the highest incidence of injury were married couples with two children, having higher or vocational education, not working, living in towns with populations of over 200,000 and having a monthly income between 1000-2000 PLN per family member. 3. External factors like weather had the most significant impact on the incidence of injury sustained in motor vehicle accidents.

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Patient mortality following alcohol use and trauma: a propensity-matched analysis

Ahmed

Greenberg

2017

Eur J Trauma Emerg Surg

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Effects of positive blood alcohol concentration on outcome and systemic interleukin-6 in major trauma patients

Cited by 39 publications

References 36 publications

Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway

Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway

Patient mortality following alcohol use and trauma: a propensity-matched analysis

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