Abstract:The effects of portacaval anastomosis on the biodynamics of cholesterol in male adult rats of a genetically hypercholesterolemic strain (Rico) were studied using an isotopic equilibrium method. Animals received a sucrose-rich semipurified diet. In both hypercholesterolemic rats and controls, portacaval anastomosis decreased plasma cholesterol levels (27%), liver weight (35–43%) and total cholesterol content in liver and body pools. Rico rats were characterized by (1) a high input rate of newly synthesized chol… Show more
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