Effects of porcine bile acids on growth performance, antioxidant capacity, blood metabolites and nutrient digestibility of weaned pigs

Cao, Aizhi; Lai, Wenqing; Zhang, W.W.; Dong, Bing; Lou, Q.Q.; Han, Meng; He, Dongting; Gai, Xiangrong; Sun, Yiwei; Zhang, L.Y.

doi:10.1016/j.anifeedsci.2021.114931

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…This result was further validated in another study in which 40-80 mg/kg BAs were added [19]. In a study on pigs, feeding BAs extracted from pig bile paste increased ADG and the digestibility of EE, and GE in piglets [20]. In this study, the addition of NBAs increased the digestibility of EE and OM and increased the ADG and ADFI of piglets.…”

Section: Discussionsupporting

confidence: 68%

Non-12α-Hydroxylated Bile Acids Improve Piglet Growth Performance by Improving Intestinal Flora, Promoting Intestinal Development and Bile Acid Synthesis

Qin,

Wei,

Cao

et al. 2023

Animals

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As an emulsifier and bioactive substance, bile acids (BAs) participate in the absorption of nutrients and in various physiological processes. The objective of this experiment was to investigate the effects of non-12α-hydroxylated BAs (including hyocholic acid, hyodeoxycholic acid and chenodeoxycholic acid, from now on referred to as NBAs) on growth performance, BAs metabolism and the intestinal flora of piglets. The experiment included four groups, with eight piglets per group. The four groups of pigs were fed 0, 60, 120 and 180 mg/kg of NBAs, respectively. The results show that adding NBAs significantly increased the final weight (FW), average daily feed intake (ADFI), average daily gain (ADG), and digestibility of crude fat (EE) and organic matter (OM) in piglets (p < 0.05). Adding NBAs significantly increased the villus height (VH) of the jejunum and ileum (p < 0.05). In addition, NBAs supplementation increased the content of urea nitrogen (BUN) and creatinine (CREA) as well as the ratio of urea nitrogen to creatinine (BUN/CREA) in serum (p < 0.05). Adding NBAs can affect the genes related to BAs enterohepatic circulation. Specifically, adding NBAs significantly decreased the relative mRNA abundance of FXR in the liver (p < 0.05), significantly increased the relative mRNA abundance of CYP27A1 (p < 0.05), and significantly increased the relative mRNA abundance of NTCP (p < 0.05). Adding NBAs also significantly decreased the relative mRNA abundance of FXR in the ileum (p < 0.05). In the full-length 16S rDNA sequencing analysis, ten biomarkers were found from the gate to the species level. NBAs mainly enriched Lactobacillus_Johnsonii and decreased the abundance of Streptococcus_alactolyticus. Short-chain fatty acids (SCFAs) content in the colon was significantly increased (p < 0.05). These results indicate that NBAs supplementation can improve the growth performance of piglets, promote the development of the bile acid replacement pathway and improve intestinal flora.

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Section: Discussionsupporting

confidence: 68%

Non-12α-Hydroxylated Bile Acids Improve Piglet Growth Performance by Improving Intestinal Flora, Promoting Intestinal Development and Bile Acid Synthesis

Qin,

Wei,

Cao

et al. 2023

Animals

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“…This resulted in an increase in the level of secondary bile acids in the serum ( Table 5 ). Bile acids and PC can participate in the emulsification of fat and promote fat digestion and absorption in the duodenum [ 56 , 57 ]. Bile acids also bind to dietary proteins in the small intestine during digestion.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Yucca schidigera Extract on Serum Metabolites of Angus Crossbreed Steers with Metabolomics

Deng,

Wu,

et al. 2024

Metabolites

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This study was conducted to explore the potential effect of Yucca schidigera extract (YSE) on the metabolism of beef cattle. Thirty Angus crossbreed steers were selected, with an initial mean body weight of 506.6 ± 33.3 kg, and assigned to two treatments: a diet with no additives (CON group) and a diet supplemented with 1.75 g/kg of YSE (YSE group) (on a dry matter basis). The experiment lasted for 104 days, with 14 days for adaptation. The results showed that adding YSE could significantly improve the average daily gain (ADG) from 1 to 59 d (15.38%) (p = 0.01) and 1 to 90 d (11.38%) (p < 0.01), as well as dry matter digestibility (DMD) (0.84%) (p < 0.05). The contents of alanine aminotransferase, aspartate aminotransferase, and bilirubin and the total antioxidant capacity were increased and blood urea was reduced in the YSE group, compared to the CON group (p < 0.05). Both the glycerophospholipids and bile acids, including phosphocholine, glycerophosphocholine, PC(15:0/18:2(9Z,12Z)), PE(18:0/20:3(5Z,8Z,11Z)), PE(18:3(6Z,9Z,12Z)/P-18:0), LysoPC(15:0), LysoPC(17:0), LysoPC(18:0), LysoPC(20:5(5Z,8Z,11Z,14Z,17Z)), deoxycholic acid, glycocholic acid, and cholic acid, were upregulated by the addition of YSE. In summary, YSE may improve the ADG by increasing the blood total antioxidant capacity and glycerophospholipid synthesis, maintaining steers under a healthy status that is beneficial for growth. Furthermore, YSE may also increase the expression of bile acid synthesis, thereby promoting DMD, which, in turn, offers more nutrients available for growth.

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“…Studies have reported the addition of BA or bile salts to broiler diets to assess the effectiveness of BA or bile salts in improving growth performance [20,21]. The basal diet supplemented with pig BA can improve the growth performance, growth and development performance, and intestinal development of weaned piglets [22]. However, there are few studies on the effects of BA on the lactation ability and antioxidant capacity of mid-lactating cows.…”

Section: Effect Of Bas On the Growth Performance Of Mid-lactation Cowsmentioning

confidence: 99%

Effects of Bile Acid Supplementation on Lactation Performance, Nutrient Intake, Antioxidative Status, and Serum Biochemistry in Mid-Lactation Dairy Cows

Chen,

Yuan,

Yang

et al. 2024

Animals

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This experiment investigated the effects of different levels of bile acid (BA) additives in diets on the lactation performance, serum antioxidant metabolites, and serum biochemical indices of 60 multiparous mid-lactation dairy cows. The cows were randomized to receive one of the four homogeneous treatments, with the BA preparation supplemented at 0, 6, 12, and 18 g/head/d. The experiment lasted for 14 weeks. The first 2 weeks were the pre-feeding period. The milk yield and composition data were recorded weekly, and the dry matter intake and antioxidative blood index were analyzed on the 6th, 10th, and 14th weeks of the study. On the 84th day of the experiment, the experimental group exhibited significantly higher levels of total protein and albumin, by 57.5% and 55.6%, respectively, compared to the control group (p < 0.05). On both the 28th and 84th days of the trial, the experimental group showed a markedly higher lipase content compared to the control group, by 26.5% and 25.2%, respectively (p < 0.05). Furthermore, the experimental group displayed notably elevated levels of superoxide dismutase, glutathione peroxidase, and total antioxidant capacity, surpassing the control group by 17.4%, 21.6%, and 8.7%, respectively. In conclusion, BA additives improve the serum antioxidant indices of dairy cows, thereby enhancing the performance of these cows.

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Effects of porcine bile acids on growth performance, antioxidant capacity, blood metabolites and nutrient digestibility of weaned pigs

Cited by 9 publications

References 23 publications

Non-12α-Hydroxylated Bile Acids Improve Piglet Growth Performance by Improving Intestinal Flora, Promoting Intestinal Development and Bile Acid Synthesis

Non-12α-Hydroxylated Bile Acids Improve Piglet Growth Performance by Improving Intestinal Flora, Promoting Intestinal Development and Bile Acid Synthesis

The Effect of Yucca schidigera Extract on Serum Metabolites of Angus Crossbreed Steers with Metabolomics

Effects of Bile Acid Supplementation on Lactation Performance, Nutrient Intake, Antioxidative Status, and Serum Biochemistry in Mid-Lactation Dairy Cows

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