Effects of poor sleep on the immune cell landscape as assessed by single-cell analysis

Liu, Xiuxing; Chen, Binyao; Huang, Zhaofeng; Duan, Runping; He, Ling; Xie, Lihui; Wang, Rong; Li, Zhaohuai; Gao, Yuehan; Zheng, Yingfeng; Su, Wenru

doi:10.1038/s42003-021-02859-8

Cited by 29 publications

(32 citation statements)

References 74 publications

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“…In a recent study, authors analyzed with mass cytometry and single-cell RNA sequencing the characteristics of peripheral blood mononuclear cells obtained from healthy subjects sleep-deprived. They found expansion of T lymphocytes and plasma cells, increase of autoimmunity markers and altered subsets of myeloid cells, confirming the relationship between sleep alteration and immune dysregulation/chronic subclinical inflammation [ 74 ].…”

Section: Sleep Deprivation Immune System and Viral Infectionsmentioning

confidence: 75%

Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Ragnoli

Pochetti

Pignatti

et al. 2022

IJERPH

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Sleep health and its adaptation to individual and environmental factors are crucial to promote physical and mental well-being across animal species. In recent years, increasing evidence has been reported regarding the relationship between sleep and the immune system and how sleep disturbances may perturb the delicate balance with severe repercussions on health outcomes. For instance, experimental sleep deprivation studies in vivo have reported several major detrimental effects on immune health, including induced failure of host defense in rats and increased risk for metabolic syndrome (MetS) and immune suppression in humans. In addition, two novel risk factors for dysregulated metabolic physiology have recently been identified: sleep disruption and circadian misalignment. In light of these recent findings about the interplay between sleep and the immune system, in this review, we focus on the relationship between sleep deprivation and immunity against viruses, with a special interest in SARS-CoV-2 infection.

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Section: Sleep Deprivation Immune System and Viral Infectionsmentioning

confidence: 75%

Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Ragnoli

Pochetti

Pignatti

et al. 2022

IJERPH

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“…Blood was collected from six healthy individuals before and after 24-h sleep deprivation (preSU and postSU, respectively) and then subsequently analyzed using mass cytometry by time of flight (CyTOF) and single-cell RNA sequencing (scRNA-seq). Coincident with the aforementioned studies, Liu et al (2021) found increases in circulating T cells (TC) as well as decreases in myeloid cells (MYE) postSU as assessed by classical lineage markers using scRNA-seq. Next, the five major immune cell lineages (TC, NK, BC, MC, and DC) were further sub-clustered into transcriptionally distinct subsets.…”

Section: Sleep Disruption-induced Changes To Systemic Physiologymentioning

confidence: 57%

“…These approaches are required to garner critical information on the molecular and cellular interactions underpinning sleep disruption associated malignancies. A study by Liu et al (2021) provide unique insight into the dynamic single-cell alterations underlying sleep disruption-induced rewiring of the immune cell landscape. Blood was collected from six healthy individuals before and after 24-h sleep deprivation (preSU and postSU, respectively) and then subsequently analyzed using mass cytometry by time of flight (CyTOF) and single-cell RNA sequencing (scRNA-seq).…”

Section: Sleep Disruption-induced Changes To Systemic Physiologymentioning

confidence: 99%

“…Following 24-h sleep deprivation, single-cell clustering identified the onset of lymphocythemia (i.e., increased number of lymphocytes) as demonstrated by increases in CD8 + effector memory TCs (CD8 T EM ), proliferating TCs (mitotic TC, T-mito), and exhausted TCs (Tex) (as a percent of CD45+). Next, Liu et al (2021) sought to identify the molecular events associated with 24-h sleep deprivation which was achieved through the analysis of differentially expressed genes from blood immune cells in the postSU group compared with the preSU group. All six participants in the study showed an increase in several inflammatory genes including markers of DNA damage, AP-1 family genes ( JUN , FOS ), IFNG and interferon-related developmental regulator 1 ( IFRD1 ).…”

Section: Sleep Disruption-induced Changes To Systemic Physiologymentioning

confidence: 99%

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Sleep Disruption and Cancer: Chicken or the Egg?

2022

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Sleep is a nearly ubiquitous phenomenon across the phylogenetic tree, highlighting its essential role in ensuring fitness across evolutionary time. Consequently, chronic disruption of the duration, timing, or structure of sleep can cause widespread problems in multiple physiological systems, including those that regulate energy balance, immune function, and cognitive capacity, among others. Many, if not all these systems, become altered throughout the course of cancer initiation, growth, metastatic spread, treatment, and recurrence. Recent work has demonstrated how changes in sleep influence the development of chronic diseases, including cancer, in both humans and animal models. A common finding is that for some cancers (e.g., breast), chronic disruption of sleep/wake states prior to disease onset is associated with an increased risk for cancer development. Additionally, sleep disruption after cancer initiation is often associated with worse outcomes. Recently, evidence suggesting that cancer itself can affect neuronal circuits controlling sleep and wakefulness has accumulated. Patients with cancer often report difficulty falling asleep, difficulty staying asleep, and severe fatigue, during and even years after treatment. In addition to the psychological stress associated with cancer, cancer itself may alter sleep homeostasis through changes to host physiology and via currently undefined mechanisms. Moreover, cancer treatments (e.g., chemotherapy, radiation, hormonal, and surgical) may further worsen sleep problems through complex biological processes yet to be fully understood. This results in a “chicken or the egg” phenomenon, where it is unclear whether sleep disruption promotes cancer or cancer reciprocally disrupts sleep. This review will discuss existing evidence for both hypotheses and present a framework through which the interactions between sleep and cancer can be dissociated and causally investigated.

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“…Rhythmical biological regulation of the immune system is mediated by intricate crosstalk between the nervous and endocrine systems [ 70 – 72 ]. Dysregulation of sleep–wake cycles, like prolonged sleep deprivation, disrupts the immune system, resulting in increased rates of viral infection and weak antigen processing and antibody formation [ 70 , 73 , 74 ].…”

Section: The Interplay Between Sleep–wake Cycles and Cancermentioning

confidence: 99%

Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

et al. 2022

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The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity–rest cycles, coordinating the behavior and physiology of all organs for whole-body homeostasis. Acute disruption of circadian rhythm may lead to transient discomfort, whereas long-term irregular circadian rhythm will result in the dysfunction of the organism, therefore increasing the risks of numerous diseases especially cancers. Indeed, both epidemiological and experimental evidence has demonstrated the intrinsic link between dysregulated circadian rhythm and cancer. Accordingly, a rapidly increasing understanding of the molecular mechanisms of circadian rhythms is opening new options for cancer therapy, possibly by modulating the circadian clock. In this review, we first describe the general regulators of circadian rhythms and their functions on cancer. In addition, we provide insights into the mechanisms underlying how several types of disruption of the circadian rhythm (including sleep–wake, eating–fasting, and activity–rest) can drive cancer progression, which may expand our understanding of cancer development from the clock perspective. Moreover, we also summarize the potential applications of modulating circadian rhythms for cancer treatment, which may provide an optional therapeutic strategy for cancer patients.

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Effects of poor sleep on the immune cell landscape as assessed by single-cell analysis

Cited by 29 publications

References 74 publications

Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Sleep Disruption and Cancer: Chicken or the Egg?

Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

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