Effects of Polyunsaturated/Saturated Fatty Acid Ratio and Antioxidant Supplementation on Hepatic TBARS and Enzyme Activities under the Maintenance of Dietary Peroxidizability Index Value in Young and Adult Rats

Kang, Min Jeong; Ahn, Hae Sun; Lee, Sang Sun

doi:10.1159/000087334

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…Food intake varied throughout the experiment and it was positively correlated with energy intake. However, diet intake affected weight gain only in the group receiving western diet, whereas this did not occur in the groups receiving PUFAs and MUFAs, as determined by the diet efficiency rate [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Vegetable Oils on the Nonalcoholic Fatty Liver Disease in C57/BL Mice

Manca

Simões-Ambrosio

Ovídio

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic disorder, affecting 22–28% of the adult population and more than 50% of obese people all over the world. Modulation of the fatty acids in diet as a means of prevention against nonalcoholic fatty liver disease in animal models (NAFLD) remains unclear. The treatment of NAFLD has not been described in specific guidelines so far. Thus, the justification for the study is to check modifications in macronutrients composition, fatty acids, in particular, play a significant role in the treatment of NAFLD regardless of weight loss. Aim. To investigate different vegetable oils in prevention and progression of NAFLD in animal models. Methods. For the experiment were used fifty C57BL/6J mice male fed with high fat and fructose diet (HFD) to induce the NAFLD status and they received different commercial vegetable oils for 16 weeks to prevent steatosis. Liver steatosis and oxidative stress parameters were analyzed using biochemical and histological methods. Fatty acids profile in the oils and in the liver samples was obtained. Results. The high fat and fructose diet led to obesity and the vegetable oils offered were effective in maintaining body weight similar to the control group. At the end of the experiment (16 weeks), the HFHFr group had a greater body weight compared to control and treated groups (HFHFr: 44.20 ± 2.34 g/animal vs. control: 34.80 ± 3.45 g/animal; p < 0.001 ; HFHFr/OL: 35.40 ± 4.19 g/animal; HFHFr/C: 36.10 ± 3.92 g/animal; HFHFr/S: 36.25 ± 5.70 g/animal; p < 0.01 ). Furthermore, the HFD diet has caused an increase in total liver fat compared to control ( p < 0.01 ). Among the treated groups, the animals receiving canola oil showed a reduction of hepatic and retroperitoneal fat ( p < 0.05 ). These biochemical levels were positively correlated with the hepatic histology findings. Hepatic levels of omega-3 decreased in the olive oil and high fat diet groups compared to the control group, whereas these levels increased in the groups receiving canola and soybean oil compared to control and the high fat groups. Conclusion. In conclusion, the commercial vegetable oils either contributed to the prevention or reduction of induced nonalcoholic fatty liver with high fat and fructose diet, especially canola oil.

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Section: Discussionmentioning

confidence: 99%

Effects of Different Vegetable Oils on the Nonalcoholic Fatty Liver Disease in C57/BL Mice

Manca

Simões-Ambrosio

Ovídio

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Investigation of the Dietary Intake and Health Status in East Africa in the 1960s: A Systematic Review of the HistoricOltersdorf Collection

Raschke

Oltersdorf²,

Elmadfa

et al. 2008

Ecology of Food and Nutrition

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Downloaded by [University of Arizona] at 01:26 11 June 2016 2 V. RASCHKE ET AL.We have recently reported on the myriad health benefits of traditional East African foods and food habits. However, this region continues to experience a nutrition transition whereby traditional, well-tried foods have been systematically replaced with the products of multinational corporations. The health-related impact has been devastating, as evidenced by current non-communicable disease (NCD) trends. The purpose of the present investigation was to review the historic Oltersdorf Collection (data collated by the Max-Planck Nutrition Research Unit, Bumbuli Tanzania from the 1930s to 1960s) to determine if adherence to traditional East African food habits was positively associated with health status indices in populations residing in Tanzania, Kenya and Uganda during this period. The systematic review process resulted in six investigations being identified. Published between 1963 and 1969, these are likely the first investigations to provide original data pertaining to dietary intake/adequacy and health status indices within specific East African cohorts. Overall, the review revealed that many ethnic groups did not exhibit adequate dietary intake and did not consume a diversity of traditional whole foods representative of the wide spectrum of food choices available within the region at this time. NCDs such as obesity, hypertension, and type 2 diabetes were not reported in any investigation. However, there was substantial reporting of malnutrition-related and infectious diseases, particularly among children. The present review supports the contention that the shift from a traditional, diversified diet to a simplified, monotonous diet may have occurred with the onset of cash-crop farming. For resolution of nutrition-related epidemics currently plaguing Africa, including NCDs and malnutrition-related diseases (i.e., the double burden) it is critically important to investigate and disseminate evidence related to the fundamental contributors to the nutrition transition.

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Effects of Polyunsaturated/Saturated Fatty Acid Ratio and Antioxidant Supplementation on Hepatic TBARS and Enzyme Activities under the Maintenance of Dietary Peroxidizability Index Value in Young and Adult Rats

Cited by 2 publications

References 62 publications

Effects of Different Vegetable Oils on the Nonalcoholic Fatty Liver Disease in C57/BL Mice

Effects of Different Vegetable Oils on the Nonalcoholic Fatty Liver Disease in C57/BL Mice

Investigation of the Dietary Intake and Health Status in East Africa in the 1960s: A Systematic Review of the HistoricOltersdorf Collection

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