Effects of Polyphosphate on Leukocyte Function

Suess, Patrick M.

doi:10.1007/978-3-031-01237-2_6

Cited by 4 publications

(4 citation statements)

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“…Leukocytes, as immune cells derived from hematopoietic stem cells of the bone marrow, play certain functions in inflammation and immune responses. 46 All immune cells recruited to the site of action play critical roles in the microenvironment and can participate in tumor development and progression. 47 The interaction between tumor cells and immune cells can lead to the aggregation of tumor cells; this also explains the differences in host protection and tumor-shaping functions of the immune system in cancer.…”

Section: Degreementioning

confidence: 99%

Bioinformatics analysis of the genes associated with co-occurrence of heart failure and lung cancer

Wang

Song

et al. 2023

Exp Biol Med (Maywood)

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Deaths of non-cardiac causes in patients with heart failure (HF) are on the rise, including lung cancer (LC). However, the common mechanisms behind the two diseases need to be further explored. This study aimed to improve understanding on the co-occurrence of LC and HF. In this study, gene expression profiles of HF (GSE57338) and LC (GSE151101) were comprehensively analyzed using the Gene Expression Omnibus database. Functional annotation, protein–protein interaction network, hub gene identification, and co-expression analysis were proceeded when the co-differentially expressed genes in HF and LC were identified. Among 44 common differentially expressed genes, 17 hub genes were identified to be associated with the co-occurrence of LC and HF; the hub genes were verified in 2 other data sets. Nine genes, including ALOX5, FPR1, ADAMTS15, ALOX5AP, ANPEP, SULF1, C1orf162, VSIG4, and LYVE1 were selected after screening. Functional analysis was performed with particular emphasis on extracellular matrix organization and regulation of leukocyte activation. Our findings suggest that disorders of the immune system could cause the co-occurrence of HF and LC. They also suggest that abnormal activation of extracellular matrix organization, inflammatory response, and other immune signaling pathways are essential in disorders of the immune system. The validated genes provide new perspectives on the common underlying pathophysiology of HF and LC, and may aid further investigation in this field.

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Section: Degreementioning

confidence: 99%

Bioinformatics analysis of the genes associated with co-occurrence of heart failure and lung cancer

Wang

Song

et al. 2023

Exp Biol Med (Maywood)

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“…Jumlah leukosit dalam darah dapat dipengaruhi oleh beberapa hal, diantaranya ada yang bersifat fisiologis dan ada pula yang bersifat patologis. Secara fisiologis peningkatan jumlah sel neutrophil dan sel limfosit dapat meningkatkan jumlah leukosit darah, begitupula peningkatan jumlah leukosit total dalam sirkulasi dapat disebabkan karena leukosit aktif melawan mikroorganisme pathogen yang dapat menyebabkan penyakit (Suess, 2022).…”

Section: Hematologiunclassified

“…Penurunan jumlah leukosit juga biasa terjadi akibat gangguan yang bersifat patologis seperti hipoplasia sunsum tulang, penyakit viral dan infeksi berat (Suess, 2022). Berdasarkan hasil penelitian pada kelinci P0U2 dan P0U3 didapatkan nilai 9,4 × 10³/mm³ dan 10,2 × 10³/mm³ sedangkan pada kelinci P1U1 dan P1U2 sebesar 12,3 × 10³/mm³ dan 13,5 × 10³/mm³ hal ini menunjukan kedua perlakuan masih dalam batas normal.…”

Section: Hematologiunclassified

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Respon Fisiologis dan Hematologi Kelinci Rex yang diberi Pakan Mengandung Indigofera zollingeriana

Nurhikmah

Nurmeiliasari²,

Amrullah³

2022

J. Sains Tek. Peter.

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Penelitian ini bertujuan untuk mengetahui pengaruh pemberian pakan mengandung daun indigofera (Indigofera zollingeriana) terhadap respon fisologis dan hematologi kelinci Rex. Penelitian menggunakan 4 ekor kelinci Rex betina yang dibagi menjadi 2 perlakuan. P0 merupakan perlakuan tanpa mengandung daun indigofera, P1 merupakan perlakuan pakan mengandung 20 % daun indigofera. Variabel yang diamati dalam penelitian yaitu: laju respirasi, denyut jantung, suhu rektal, suhu kulit, kadar hemoglobin, jumlah eritrosit, nilai, jumlah leukosit, dan kadar glukosa. Data respon fisiologis didapatkan dari masing-masing 4 ekor kelinci di tiap perlakuan. Data respon fisiologis dianalisis menggunakan T-test, dan data hematologi didapatkan dari masing-masing dua ekor kelinci dari tiap perlakuan, dan data dianalisis secara deskriptif. Hasil penelitian menunjukkan pemberian daun indigofera tidak memberikan pengaruh pada respon fisiologis kelinci. Hematologi kelinci yang diberi pakan daun indigofera masih dalam batas normal. Kelompok diet non-indigofera memiliki hemoglobin 11,5; eritrosit 3,7 × 106/mm3; 37,7 %; leukosit 9,8 × 103/mm3 dan glukosa 77,5 mg/dL. Kelinci pada kelompok indigofera memiliki hemoglobin 12,2, jumlah eritrosit 4,15 × 106/mm3, 39,55 %, leukosit 12,9 × 103/mm3 dan glukosa 87,0 mg/dL. Berdasarkan hasil penelitian dapat disimpulkan bahwa daun indigofera dapat digunakan hingga level 20 % tanpa memberikan pengaruh negatif terhadap respon fisiologis dan hematologi kelinci Rex.

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Inorganic polyphosphate regulates functions of thymocytes via activation of P2X purinoreceptors

Nebesnaya,

Makhmudov,

Rustamov

et al. 2024

Biochimica et Biophysica Acta (BBA) - General Subjects

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Effects of Polyphosphate on Leukocyte Function

Cited by 4 publications

References 59 publications

Bioinformatics analysis of the genes associated with co-occurrence of heart failure and lung cancer

Bioinformatics analysis of the genes associated with co-occurrence of heart failure and lung cancer

Respon Fisiologis dan Hematologi Kelinci Rex yang diberi Pakan Mengandung Indigofera zollingeriana

Inorganic polyphosphate regulates functions of thymocytes via activation of P2X purinoreceptors

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