Effects of Polyphenols Supplemented Canola Meal Based Diet on Proximate Composition, Minerals Absorption and Hematology of Cyprinus carpio Fingerlings

Abstract

Coronavirus disease 2019 (COVID-19) is a pandemic and this disease has infected millions of people globally now. COVID-19 is caused by a novel beta coronavirus strain known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Once SARS-CoV-2 manages to enter the body, it identifies and binds to the angiotensin converting enzyme 2 (ACE2) receptors through the binding receptor of Spike Protein (S-protein). The present study aimed to investigate the phytochemicals as potential inhibitors of the binding domain of S protein so that the binding of COVID-19 with ACE2 receptors could be restrained. For this purpose, the library of 2113 phytochemicals was docked against the binding domain of the S-protein. Top ten compounds with maximum binding affinity to the active sites of target protein were further screened for ADMET properties by adopting SwissADME and ADMETsar online servers. The compounds namely Morin, Curcumin, Apigenin, Cedronolactone A and Matairesinol showed acceptable drug-like properties therefore these compounds can be proposed as effective inhibitors, disrupting the S-protein-ACE2 interaction. This study might help in the development of a natural and cost-effective drug against COVID-19. Further, in vivo and in vitro examinations are required to validate our results.

Biochar as a feed supplement for nutrient digestibility and growth performance of Catla catla fingerlings

“…MOSM, having reasonably high protein content, is a suitable protein replacer for fish meals. MOSM is considered more cost-effective as compared to both fish meals and soybean meals ( Hussain et al, 2022 ).…”

Impact of feeding biochar sources in rohu (Labeo rohita): Evaluating the growth, nutrient absorption, carcass composition, haematology and mineral status

“…The apparent digestibility coefficient (ADC%) of experimental diets was determined by using the following formula, as mentioned by Hussain et al (2022). $$$\text{ADC} \% =100-\left[100\times \frac{ \% \,\text{marker in faeces}\times \% \,\text{nutrient in faeces}}{ \% \,\text{marker in faeces}\times \% \,\text{nutrient in diet}}\right].$$$…”

“…The apparent digestibility coefficient (ADC%) of experimental diets was determined by using the following formula, as mentioned by Hussain et al (2022).…”

“…Moringa oleifera seed meal (MOSM), because of its high protein content can be used as a suitable substitute for fishmeal. It has been suggested that MOSM is less expensive than fishmeal (Hussain et al, 2022). The moringa tree is commonly identified as Lam or the horseradish tree.…”

Evaluation of growth, nutrient absorption, body composition and blood indices under dietary exposure of iron oxide nanoparticles in Common carp (Cyprinus carpio)

“…Three fingerlings (24 h fasted fish) from each tank were taken for haematological analysis after the experiment was done. To do this, fingerlings were anaesthetised for 15 min with a solution containing 150 mg of tricane methane sulfonate (Hussain et al, 2023; Wagner et al, 1997). Anesthesia was administered to fingerlings with care to minimise stress.…”