Effects of Polyphenol Substances Derived from<i>Theobroma cacao</i>on Gastric Mucosal Lesion Induced by Ethanol

Osakabe, Naomi; Sanbongi, Chiaki; Yamagishi, Megumi; Takizawa, Toshio; Osawa, Toshihiko

doi:10.1271/bbb.62.1535

Cited by 48 publications

(34 citation statements)

References 23 publications

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“…Some phenolics have been reported to have antiulcerative and gastroprotective properties (Borrelli & Izzo, 2000;Osakabe et al, 1998) due to their free-radical scavenging and antioxidant properties which enhanced mucus production and antisecretory action (Di Carlo et al, 1999). In vitro antioxidant tests in our previous studies (Data not shown) have showed that the methanol extract of C. viscosa is a good antioxidant and free-radical scavenger.…”

Section: Discussionmentioning

confidence: 87%

Protective effect of standardized extract ofCleome viscosaagainst experimentally induced gastric lesions in the rat

Gupta

Rao

Sharma

2013

Pharmaceutical Biology

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Context: Cleome viscosa Linn. (Capparidaceae) is used traditionally in the Indian system of medicine as a carminative, anthelmintic, and diuretic, and used for healing wounds, ulcers and diarrhea. Objective: A 70% ethanol (EtOH) extract of the aerial parts of Cleome viscosa extract (CVE) was investigated for gastroprotective activity in different gastric ulcer models in order to validate ethnobotanical claims regarding the plant use in ulcers. Materials and methods: CVE (100, 200 and 400 mg/kg body weight) was administered orally, twice daily for 5 d, for prevention from EtOH, pylorus ligation (PL) and cold restraint stress (CRS)-induced ulcers in rats. Estimation of H þ K þ ATPase activity and gastric wall mucous were performed in EtOH-induced ulcer, antioxidant enzyme activities in supernatant mitochondrial fraction of CRS-induced ulcer, and gastric secretion parameters were estimated in PL-induced ulcer model Results: CVE showed significant (p50.01) dose-dependent inhibition of lesion index in EtOH 15.93-42.30%, PL 26.34-59.28% and CRS 22.58-54.03%, respectively. CVE prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by a significant (p50.001) decrease in superoxide dismutase, and an increase in catalase activity. A significant (p50.01) decrease occurred in the level of H þ K þ ATPase, volume of gastric juice and total acidity. Simultaneously, the level of gastric wall mucus and pH were increased significantly (p50.05). High performance thin layer chromatography analysis showed the presence of quercetin and gallic acid (0.3% and 0.25% w/w, respectively) in CVE. Conclusions: Results of our study showed that C. viscosa possesses significant gastroprotective activity, probably due to free radical scavenging activity, and validates the folklore claim.

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Section: Discussionmentioning

confidence: 87%

Protective effect of standardized extract ofCleome viscosaagainst experimentally induced gastric lesions in the rat

Gupta

Rao

Sharma

2013

Pharmaceutical Biology

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“…Some antioxidants are used to protect gastrointestinal mucosa and apical epithelial membrane. In rats, the Cacao Liquor watersoluble crude polyphenols (CWSP) has been shown radical scavenging ability as well as reduce ethanol-induced gastric lesions (Osakabe et al, 1998). The normal blood level of vitamin-C is 3.2-8.9m/ L in dogs, (Hishiyama et al, 2006).…”

Section: Antioxidant Therapymentioning

confidence: 99%

Gastritis and Peptic Ulcer Diseases in Dogs: A Review

Patel¹,

Patel²,

Dixit³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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“…These bioactive principles are often associated with lignin as ester groups and are extracted either as components of alcohol insoluble fractions or bound to simple glycosides as alcohol soluble fractions [7,152]. Common phenolics among the angiosperms are p-hydroxyl-benzoic acids, protocatetuic acids, vanillic acid and syringic acid (Figure 8).…”

Section: Phenols and Phenolic Acidsmentioning

confidence: 99%

“…The coumarins are antimicrobial, anti-inflammatory [193][194][195], antioxidant [106,112,193,[196][197][198][199], anti-diabetic [198,200], hepatoprotective [198], anti-thrombotic [193,196,201], anti-fungal [193,195], anti-viral [112], analgesic [195] and anti-carcinogenic [152,202,203] agents.…”

Section: Coumarinsmentioning

confidence: 99%

Medicinal Potentials and Toxicity Concerns of Bioactive Principles

CO¹

2015

Med Aromat Plants

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Effects of Polyphenol Substances Derived fromTheobroma cacaoon Gastric Mucosal Lesion Induced by Ethanol

Cited by 48 publications

References 23 publications

Protective effect of standardized extract ofCleome viscosaagainst experimentally induced gastric lesions in the rat

Protective effect of standardized extract ofCleome viscosaagainst experimentally induced gastric lesions in the rat

Gastritis and Peptic Ulcer Diseases in Dogs: A Review

Medicinal Potentials and Toxicity Concerns of Bioactive Principles

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