Effects of polypharmacy and anticholinergic/sedative drugs on the physical/cognitive/mental related outcomes of community-dwelling elderly people: The Kawasaki Wellbeing Project

Tanaka, Asahi; Arai, Yasumichi; Hirata, Takumi; Abe, Yukiko; Oguma, Yuko; Urushihara, Hisashi

doi:10.3143/geriatrics.56.504

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…In addition, several studies had shown similar results to ours that increasing the number of medications was related with lowering HRQOL. 14,15) In contrast, the association between adherence and HRQOL in the studies targeting speciˆc diseases such as hypertension, diabetes mellitus and epilepsy has been reported. 5,6) Our study, consisting of community-dwelling elderly participants, showed a similar association.…”

Section: Discussionmentioning

confidence: 98%

“…To identify factors that were independently associated with medication adherence, variables with a p value of less than 0.1 in the univariate analysis were introduced into a multivariate model using binary logistic regression with the forced entry method. Additionally, to clarify the eŠect of medication adherence on HRQOL, we conducted a multiple linear regression analysis (stepwise selection) and the variables included in the model were the factors of participants' characteristics, number of medications, which was a reported relevant variable to HRQOL in previous studies 14,15) , and VAS score. Associations are expressed as adjusted odds ratios (AORs) with 95％ conˆdence intervals (CIs).…”

Section: Assessment Of Medication Adherencementioning

confidence: 99%

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Factors Associated with Self-reported Medication Adherence in Japanese Community-dwelling Elderly Individuals: The Nakajima Study

et al. 2021

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Section: Discussionmentioning

confidence: 98%

Section: Assessment Of Medication Adherencementioning

confidence: 99%

Factors Associated with Self-reported Medication Adherence in Japanese Community-dwelling Elderly Individuals: The Nakajima Study

et al. 2021

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Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome

Taylor‐Rowan

Edwards

Noel-Storr

et al. 2021

Cochrane Database of Systematic Reviews

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This is a protocol for a Cochrane Review (Prognosis). The objectives are as follows:Primary objective: to assess whether ACB in older adults is a prognostic factor for future cognitive decline or dementia. Secondary objective(s):to assess whether ACB is a prognostic factor for older adults recruited in primary care, secondary care, or community settings (with setting used as the basis for subgroup analyses); whether ACB is associated with mortality; to compare the prognostic validity of respective ACB scales; and to examine the e ect of duration of exposure and duration of follow-up on the ACBdementia risk association.Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome (Protocol)

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Association between physical activity patterns and quality of life in Japanese adults aged 85 to 89 years: a cross-sectional study

Muramatsu,

Oguma,

Abe

et al. 2023

Preprint

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Background Associations between physical activity (PA) and quality of life (QOL) are usually studied in people in their 60s and 70s, and little is known about them in older age groups.We evaluated the association between PA and QOL in Japanese adults aged 85-89 years and revealed the PA patterns in this population. Methods This cross-sectional study (n = 914) used baseline data from the Kawasaki Aging and Well-being Project (KAWP), a longitudinal cohort study of older adults aged 85-89 years. QOL was assessed using the EuroQoL 5D-5L (EQ-5D-5L) and the WHO Five Well-Being Index (WHO-5). PA was objectively and subjectively measured using a triaxial accelerometer and modified Zutphen Physical Activity Questionnaire, respectively. Associations were analyzed using multivariable regression analysis. Results The higher PA was significantly associated with a higher EQ-5D-5L index score (coefficient, 0.004; 95%CI, 0.001-0.008). In contrast, no association was observed between PA and the WHO-5 total score (coefficient, 0.103; 95%CI, -0.066-0.271). Calisthenics were the most commonly performed sports or exercises (27.4% of male and 47.6% of female participants). In the subgroup of participants with >median PA, the following sports/exercises were more frequently performed in addition to calisthenics; resistance trainingand others among male participants: stretching/yoga among female participants. Conclusions Our findings suggest that PA is associated with a better health-related QOL; however, no association was observed between PA and psychological well-being in this population. More physically active older adults perform several types of sports and exercises in addition to calisthenics.

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Effects of polypharmacy and anticholinergic/sedative drugs on the physical/cognitive/mental related outcomes of community-dwelling elderly people: The Kawasaki Wellbeing Project

Cited by 4 publications

References 13 publications

Factors Associated with Self-reported Medication Adherence in Japanese Community-dwelling Elderly Individuals: The Nakajima Study

Factors Associated with Self-reported Medication Adherence in Japanese Community-dwelling Elderly Individuals: The Nakajima Study

Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome

Association between physical activity patterns and quality of life in Japanese adults aged 85 to 89 years: a cross-sectional study

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