Effects of polymerization heat and monomers from acrylic cement on canine bone

Stürup, Jens; Nimb, Lars; Kramhøft, M; Jensen, Jørgen Steen

doi:10.3109/17453679408993711

Cited by 61 publications

(26 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bone is deeply located in the body, too hard to approach penetrating the cortex, and low-thermal conductive with highly vascularized medulla. Hyperthermia for bone tumors using the polymerization heat of polymethylmethacrylate bone cement is now widely performed [30,31]. However, the generated heat tends to be unreliable and Fig.…”

Section: Discussionmentioning

confidence: 99%

Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field

Matsumine

Kusuzaki

Matsubara

et al. 2007

Clin Exp Metastasis

View full text Add to dashboard Cite

We have developed a novel hyperthermic treatment modality using magnetic materials for metastatic bone tumors. The purpose of this study is to show the results of novel hyperthermia for metastatic bone tumors. This novel hyperthermic treatment modality was used for 15 patients with 16 metastatic bone lesions. In seven lesions, after curettage of the metastatic lesion followed by reinforcement with a metal intramedullary nail or plate, calcium phosphate cement (CPC) containing powdery Fe3O4 was implanted into the cavity. In one lesion, prosthetic reconstruction was then performed after an intralesional tumor excision. For the remaining eight lesions, metal intramedullary nails were inserted into the affected bone. Hyperthermic therapy was started at 1 week postoperatively. To comparatively evaluate the radiographic results of patients who underwent hyperthermia (HT group), we also assessed eight patients who received a palliative operation without either radiotherapy or hyperthermia (Op group), and 22 patients who received operation in combination with postoperative radiotherapy (Op + RT group). In HT group, all patients had an acceptable limb function with pain relief without any complications. On radiographs, 87, 38, and 91% were, respectively, considered to demonstrate an effective treatment outcome in HT group, Op group, and Op + RT group. The patients in HT group showed a statistically better radiographic outcome than the patients in Op group (P = 0.0042). But when compared between HT group and Op + RT group, there were no significant difference (P = 0.412). This first series of clinical hyperthermia using magnetic materials achieved good local control of metastatic bone lesion.

show abstract

Section: Discussionmentioning

confidence: 99%

Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field

Matsumine

Kusuzaki

Matsubara

et al. 2007

Clin Exp Metastasis

View full text Add to dashboard Cite

show abstract

“…However, even if these external sources are applied for bone metastases, it is difficult to achieve enough heat conduction to the tumor because the bone is located deep in the body and has low thermal conductivity, with a highly vascularized medulla. However, hyperthermia for bone tumors can be achieved using the polymerization heat of polymethylmethacrylate bone cement as a hyperthermic treatment [13,14]; however, the generated heat tends to be unreliable and insufficient to reduce bone tumor growth [15]. Microwave-induced hyperthermia [11], laser-induced thermotherapy [16], and radiofrequency ablation [17] have been recently used, especially for spinal and pelvic metastasis.…”

Section: Introductionmentioning

confidence: 99%

A novel hyperthermia treatment for bone metastases using magnetic materials

et al. 2011

View full text Add to dashboard Cite

Patients with bone metastases in the extremities sometimes require surgical intervention to prevent deterioration of quality of life due to a pathological fracture. The use of localized radiotherapy combined with surgical reinforcement has been a gold standard for the treatment of bone metastases. However, radiotherapy sometimes induces soft tissue damage, including muscle induration and joint contracture. Moreover, cancer cells are not always radiosensitive. Hyperthermia has been studied since the 1940s using an experimental animal model to treat various types of advanced cancer, and studies have now reached the stage of clinical application, especially in conjunction with radiotherapy or chemotherapy. Nevertheless, bone metastases have several special properties which discourage oncologists from developing hyperthermic therapeutic strategies. First, the bone is located deep in the body, and has low thermal conductivity due to the thickness of cortical bone and the highly vascularized medulla. To address these issues, we developed new hyperthermic strategies which generate heat using magnetic materials under an alternating electromagnetic field, and started clinical application of this treatment modality. The purpose of this review is to summarize the latest studies on hyperthermic treatment in the field of musculoskeletal tumors, and to introduce the treatment strategy employing our novel hyperthermia approach.

show abstract

“…However, PMMA is an exothermic polymer, which may cause bone necrosis, toxin release, and/or neural injury. 25,26 Moreover, the removal of PMMA is a notably difficult and risky procedure. The alternative augmentation material is the calcium sulfate bone graft, which has a higher potential for biologic incorporation.…”

mentioning

confidence: 99%

Biomechanical Comparison of Anatomic Trajectory Pedicle Screw versus Injectable Calcium Sulfate Graft-Augmented Pedicle Screw for Salvage in Cadaveric Thoracic Bone

Derinçek

Mehbod

et al. 2006

Journal of Spinal Disorders &Amp; Techniques

View full text Add to dashboard Cite

Many salvage options for failed thoracic pedicle screws exist including the use of a different trajectory or the augmentation of the screw with polymethylmethacrylate cement. Although polymethylmethacrylate immediately increases the construct stiffness and the pull-out strength, it may cause bone necrosis, toxin relaxation, and/or neural injury. On the other hand, calcium sulfate bone grafts have a high potential for biologic incorporation and no thermal damage effect. In the current study, polyaxial pedicle screws were first inserted with a straightforward approach on both sides in 17 fresh human cadaveric thoracic vertebrae. The maximal insertion torque for each screw was measured and then the pull-out strengths were recorded. Afterward, these pedicle screws were randomly assigned to be replaced either by graft augmentation or by anatomic trajectory technique for salvage. The graft-augmented screws were placed using the previous holes. The maximum insertional torque for each anatomic trajectory screw was measured. Finally, the pull-out strengths of the revision screws were recorded. The mean maximum insertional torque decreased with the anatomic trajectory salvage technique when compared with the straightforward approach, 0.23 versus 0.38 Nm, respectively (P=0.003). The anatomic trajectory revision resulted in decreased pull-out strength when compared with the pull-out strength of the straightforward technique, 297 versus 469 N, respectively (P=0.003). The calcium sulfate graft augmentation increased the pull-out strength when compared with the pull-out strength of the straightforward technique, 680 versus 477 N, respectively (P=0.017). The mean pull-out strength ratio of revised screw to original was 0.71 for anatomic trajectory and 1.8 for graft-augmented screws, a statistically significant difference (P=0.002).

show abstract

Effects of polymerization heat and monomers from acrylic cement on canine bone

Cited by 61 publications

References 8 publications

Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field

Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field

A novel hyperthermia treatment for bone metastases using magnetic materials

Biomechanical Comparison of Anatomic Trajectory Pedicle Screw versus Injectable Calcium Sulfate Graft-Augmented Pedicle Screw for Salvage in Cadaveric Thoracic Bone

Contact Info

Product

Resources

About