Effects of Polymer Concentration and Temperature on Micellization of Cetyltrimethylammnium Bromide (Ctab) in Aqueous PVP-Ctab Mixed System

Abstract

Polymeric micelles supply an environment, which can be cautiously regulated for drug delivery. The self-assembly of polymeric micellization is dynamic. Micellization thermodynamic describes how the system defines the formation of micelles. The present study enables the micellization behavior of the surfactants in the presence of polymer to be examined by conductometric and tensiometric methods. The effects of polymer concentration and temperature on the micellization thermodynamics of a neutral soluble polymer and cationic cetyltrimethylammomium bromide (CTAB) surfactant mixture in aqueous medium were investigated. To examine polymer-surfactant interaction, critical micellar concentration (CMC) and thermodynamic parameters such as standard free energy ∆G, enthalpy ∆H and entropy ∆S are calculated by using a pseudophase model. Based on CMC, ΔG, ΔH and ΔH, the dependence of the compensation temperature on the polymer effect is discussed. This advanced work to understand micelle stability and compatibility can be comprehensively feasible in polymeric systems.

Influences of NaCl and Na2SO4 on the Micellization Behavior of the Mixture of Cetylpyridinium Chloride + Polyvinyl Pyrrolidone at Several Temperatures

“…This is a common occurrence for the aggregation of surface active materials [ 25 , 51 ]. A similar pattern was reported by Masalci [ 54 ], where the Δ G 0 values follow the trend we noticed. It is also reported by Masalci [ 54 ] that Δ G 0 is shown to fall to higher negative values as the temperature rises when the polymer is increased in quantity.…”

“…A similar pattern was reported by Masalci [ 54 ], where the Δ G 0 values follow the trend we noticed. It is also reported by Masalci [ 54 ] that Δ G 0 is shown to fall to higher negative values as the temperature rises when the polymer is increased in quantity. In the absence of electrolytes in the solution, Δ G 0 1,m values become more negative as the temperature rises, eventually remaining nearly constant.…”

Drug Extended-Release System Utilizing Micelle Formation of Highly Water-Soluble Drugs and a Counter Polymer

“…PEG increased cmc of a cationic surfactant of cetyldiethylethanolammonium bromide . Another study indicated that change in cmc of cetyltrimethylammomium bromide was a little in 0.5–2.0% polyvinylpyrrolidone solutions . Eudragit E100, a cationic polymethylmethacrylate, destabilized micelles of sodium dodecyl sulfate (anionic surfactant) .…”