Effects of polycyclic aromatic hydrocarbons (PAHs) on an aquatic ecosystem: acute toxicity and community-level toxic impact tests of benzo[a]pyrene using lake zooplankton community

Ikenaka, Yoshinori; Sakamoto, Masaki; Nagata, Takamaru; Takahashi, Hirokazu; Miyabara, Yuichi; Hanazato, Takayuki; Ishizuka, Mayumi; Isobe, Takeshi; Kim, Junwoo; Chang, Kwang‐Hyeon

doi:10.2131/jts.38.131

Cited by 35 publications

(16 citation statements)

References 15 publications

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“…(Lee et al, 2015, Dew et al, 2015, Huang et al, 2016, Kurek et al, 2013, Kirk et al, 2014, Tolton et al, 2012, Kelly et al, 2009. In particular, polycyclic aromatic compounds (PACs), which include polycyclic aromatic hydrocarbons (PAHs) and dibenzothiophenes (DBTs), are organic compounds that have been found to be toxic, carcinogenic, and/or mutagenic to aquatic biota (Sanz-Lazaro et al, 2008, CCME, 1999, OMOE, 1990, Turcotte, 2008, Yang et al, 2010, Ikenaka et al, 2013, Ball and Truskewycz, 2013, Eisler, 1987).…”

Section: Study Objectivesmentioning

confidence: 99%

“…Polycyclic aromatic compounds (PACs) are a group of organic compounds of particular concern since they are ubiquitous in the environment and have been shown to be toxic, carcinogenic, and/or mutagenic to many aquatic organisms, including amphibians (Sanz-Lazaro et al, 2008, CCME, 1999, OMOE, 1990, Turcotte, 2008, Yang et al, 2010, Ikenaka et al, 2013, Ball and Truskewycz, 2013, Eisler, 1987.…”

Section: Introductionmentioning

confidence: 99%

“…Comparison between the PAC concentrations (±SE) measured in the water of 5 wetlands from the Athabasca oil sands region (μg L -1 ) and the current Canadian water quality guidelines based on the protection of freshwater life for 9 PACs (μg L -1 ) (CCME, 2010 Contaminants associated with the Athabasca oil sands and the oil industry may have adverse effects on individual organisms as well as entire ecosystems. In particular, polycyclic aromatic compounds (PACs) are of great concern to aquatic biota and ecosystems (Eisler, 1987, Laender et al, 2011, Wu et al, 2011, Ikenaka et al, 2013. Not only are PACs toxic, carcinogenic, and/or mutagenic organic compounds (Sanz-Lazaro et al, 2008, IARC, 1998, OMOE, 1990, but due to their hydrophobicity, some PACs also have a tendency to bioaccumulate in organisms (Hellou et al, 2012, Leppanen, 1999, Schwarzenbach et al, 2003.…”

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confidence: 99%

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Toxicokinetics and bioaccumulation of polycyclic aromatic compounds in wood frog tadpoles (Lithobates sylvaticus) exposed to Athabasca oil sands sediment

et al. 2019

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Many polycyclic aromatic compounds (PACs) are toxic, carcinogenic, and mutagenic. As a result, their effects on aquatic biota and ecosystems are of great concern. Research on PACs in aquatic biota often overlooks the role of amphibians, alkylated PACs, and sediment as an uptake route. In order to study the accumulation and toxicokinetics of PACs following sediment and aqueous exposure, and to compare the bioaccumulation potentials of parent and alkyl PACs, two accumulation-elimination experiments using wood frog tadpoles (Lithobates sylvaticus) of Gosner stage 28-32 were conducted (one evaluating exposure to contaminated sediment and water, and the other to contaminated water alone). A complementary field study was then conducted near Fort McMurray, Alberta to assess PAC body burdens in field-collected amphibian larvae, and to determine whether PAC body burdens are related to exposure to sediment and/or water in the field. The results of our studies showed that PAC concentrations and uptake rates in wood frog tadpoles were highest when they were exposed to PAC-contaminated sediment. Consequently, we determined that the dominant route of exposure of wood frog tadpoles to PACs is sediment rather than water. This finding supports other studies that have shown dietary uptake to be an important route of PAC exposure in other aquatic organisms. In both the laboratory and field study, alkyl PAC concentrations exceeded those of parent PACs in wood frog tadpoles, which also demonstrated petrogenic PAC profiles. Interestingly, parent PACs seemed to have greater bioaccumulation potential than alkyl PACs in the laboratory-exposed wood frog tadpoles

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Section: Study Objectivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Toxicokinetics and bioaccumulation of polycyclic aromatic compounds in wood frog tadpoles (Lithobates sylvaticus) exposed to Athabasca oil sands sediment

et al. 2019

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“…It recognizes a large class of xenobiotics, from different drugs3 to various pollutants, such as PAHs56111225. The latter are highly ubiquitous environmental contaminants and include toxic compounds with cytotoxic, genotoxic and carcinogenic properties262728. It has already been demonstrated that P-gp expression may be induced after exposure to PAHs in different cells models and/or organisms, suggesting that P-gp may be used as a potential biomarker of environmental pollution511122529.…”

Section: Discussionmentioning

confidence: 99%

P-gp expression in brown trout erythrocytes: evidence of a detoxification mechanism in fish erythrocytes

Valton

Amblard

Wawrzyniak

et al. 2013

Sci Rep

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Blood is a site of physiological transport for a great variety of molecules, including xenobiotics. Blood cells in aquatic vertebrates, such as fish, are directly exposed to aquatic pollution. P-gp are ubiquitous “membrane detoxification proteins” implicated in the cellular efflux of various xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs), which may be pollutants. The existence of this P-gp detoxification system inducible by benzo [a] pyrene (BaP), a highly cytotoxic PAH, was investigated in the nucleated erythrocytes of brown trout. Western blot analysis showed the expression of a 140-kDa P-gp in trout erythrocytes. Primary cultures of erythrocytes exposed to increasing concentrations of BaP showed no evidence of cell toxicity. Yet, in the same BaP-treated erythrocytes, P-gp expression increased significantly in a dose-dependent manner. Brown trout P-gp erythrocytes act as membrane defence mechanism against the pollutant, a property that can be exploited for future biomarker development to monitor water quality.

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“…The two main freshwater toxicity tests with invertebrates that are routinely used are the 21-day Daphnia [70][71][72][73][74][75] and the 7-day Ceriodaphnia survival and reproduction tests. It has been employed in toxicity studies of antibiotics [40], steroids [41], analgesics [42], and many other pollutants [43]. Two types of bioassays are commonly performed with it: 48-h acute tests using neonates that are <24 h old and 21-day chronic life-cycle tests that are run from birth.…”

Section: Bioassaysmentioning

confidence: 99%

Application of Bioassays/Biosensors for the Analysis of Pharmaceuticals in Environmental Samples

Valera

Babington

Broto

et al. 2013

Analysis, Removal, Effects and Risk of Pharmaceuticals in the Water Cycle - Occurrence and Transformation in the Environment

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Effects of polycyclic aromatic hydrocarbons (PAHs) on an aquatic ecosystem: acute toxicity and community-level toxic impact tests of benzo[a]pyrene using lake zooplankton community

Cited by 35 publications

References 15 publications

Toxicokinetics and bioaccumulation of polycyclic aromatic compounds in wood frog tadpoles (Lithobates sylvaticus) exposed to Athabasca oil sands sediment

Toxicokinetics and bioaccumulation of polycyclic aromatic compounds in wood frog tadpoles (Lithobates sylvaticus) exposed to Athabasca oil sands sediment

P-gp expression in brown trout erythrocytes: evidence of a detoxification mechanism in fish erythrocytes

Application of Bioassays/Biosensors for the Analysis of Pharmaceuticals in Environmental Samples

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