Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts

Dai, Yifeng; Xu, Xijin; Huo, Xia; Faas, Marijke M.

doi:10.1016/j.ecoenv.2023.115314

Cited by 16 publications

(5 citation statements)

References 156 publications

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“…Therefore, congeners such as BaP, CHRY, IND, and DahA, among others, may be found in the blood, placenta, and maternal-fetal cord white blood cells in pregnant women exposed to air pollution [12,13]. For instance, in case studies, BaP has been found at higher levels in the placentas of a preterm delivery group compared to those of a full-term delivery group [14].…”

Section: Introductionmentioning

confidence: 99%

Traffic and Industrial Contributions of Particle-Bound PAHs during an Air Pollution Event in the Metropolitan Area of Medellin-Colombia: Inhalation Intake Risk during Pregnancy

Narváez-Valderrama,

Alzate-B,

Correa-Gil

et al. 2024

Atmosphere

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Air pollution includes particle-bound polycyclic aromatic hydrocarbons (PAHs), which eventually reach the placenta, triggering adverse perinatal outcomes through long-term exposure. Lately, air pollution has increased over the Metropolitan Area of Medellin-Colombia (MAMC), but its effects on pregnancy are still unknown. In this research, a real-time analysis of total airborne PAHs was made using a photoelectric sensor for residential places influenced by the industrial and traffic sources affecting the southern and northern MAMC during the second peak of the bimodal tendency for PM2.5 emissions in this region. Additionally, individual PAHs were analyzed by GC/MS coupled with pressurized hot water extraction methodology. The data were applied using an inhalation intake model to assess pregnancy exposure. The average concentration of PAHs in the southern MAMC was three times higher than in the northern MAMC, where the missed abortion rate has been 1.4 times higher according to the database. Previous research indicates that PAHs act as endocrine-disrupting chemicals (EDCs) during pregnancy and that even heavy congeners could reside in umbilical cord blood. Finally, the annual series of missed abortion rates in the MAMC exhibited a significant correlation with the annual average levels of PM2.5, which were associated with PAHs through correlation analysis (r2 = 0.69, p < 0.01). While this significant correlation does not imply causality, our results suggest an important connection between both variables, opening a gap for a deeper understanding of how regions with high PAH convergence influence the missed abortion rates in MAMC.

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Section: Introductionmentioning

confidence: 99%

Traffic and Industrial Contributions of Particle-Bound PAHs during an Air Pollution Event in the Metropolitan Area of Medellin-Colombia: Inhalation Intake Risk during Pregnancy

Narváez-Valderrama,

Alzate-B,

Correa-Gil

et al. 2024

Atmosphere

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“…These compounds are highly persistent, and recent studies have documented their widespread occurrence in various food products globally [7][8][9][10]. It is widely confirmed that PAHs are toxic to human health, which can cause severe health issues such as carcinogenic, teratogenic, and mutagenic effects [11][12][13][14]. Consequently, the level of PAHs in food is a matter of public concern, given that food consumption represents the major route of PAH exposure for the general populace, particularly non-smokers and non-occupationally exposed individuals [15].…”

Section: Introductionmentioning

confidence: 99%

Polycyclic Aromatic Hydrocarbons’ Impact on Crops and Occurrence, Sources, and Detection Methods in Food: A Review

Liu,

Zhang,

Pan

et al. 2024

Foods

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Polycyclic aromatic hydrocarbons (PAHs) represent a category of persistent organic pollutants that pose a global concern in the realm of food safety due to their recognized carcinogenic properties in humans. Food can be contaminated with PAHs that are present in water, air, or soil, or during food processing and cooking. The wide and varied sources of PAHs contribute to their persistent contamination of food, leading to their accumulation within these products. As a result, monitoring of the levels of PAHs in food is necessary to guarantee the safety of food products as well as the public health. This review paper attempts to give its readers an overview of the impact of PAHs on crops, their occurrence and sources, and the methodologies employed for the sample preparation and detection of PAHs in food. In addition, possible directions for future research are proposed. The objective is to provide references for the monitoring, prevention, and in-depth exploration of PAHs in food.

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“…Benzo(a)pyrene is a polycyclic aromatic hydrocarbon (PAH) of hazard degree I able to produce mutagenic, carcinogenic (IARC's group A carcinogen) and immunosuppressing effects [1,2].…”

mentioning

confidence: 99%

“…Benzo(a)pyrene levels in ambient air and contamination with this PAH in the examined children's blood were identified by using highperformance liquid chromatography on an Agilent 1200 (USA) in conformity with the Methodical Guidelines MUK 4.1.3040-12 1 and MUK 4.1.1273-03 2 .…”

mentioning

confidence: 99%

Polymorphism of TP53 (rs1042522) gene and peculiarities of the immune profile in children exposed to airborne benzo(a)pyrene

Dolgikh,

Nikonoshina

2024

Health Risk Analysis

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Examining peculiarities of an immune profile and genetic polymorphisms is especially relevant when identifying markers of effect and sensitivity to exposure to benzo(a)pyrene in northern areas. We examined 1253 children who lived in industrial centers and on conditionally clean territories in the north and south of Eastern Siberia. Levels of benzo(a)pyrene in ambient air and in children’s blood were determined by using HPLC. TP53 (rs1042522) polymorphism was examined by using real-time PCR; p53 levels were identified with flow cytofluorometry; IgG to benzo(a)pyrene, by the radioallergosorbent tests. Exposure of children in Northern Siberia to airborne benzo(a)pyrene at the dose of 7.11•10-3 µg/(kg•day) causes ben-zo(a)pyrene contamination in blood, activates apoptosis (p53) and stimulates occurrence of specific sensitization (IgG to benzo(a)pyrene) (p < 0.05). Similar disorders were established in children in Southern Siberia under exposure to airborne benzo(a)pyrene at the dose of 86.46•10-3 µg/(kg•day). The detected changes in immune profiles of children living in Northern Siberia are associated with G-allele and GG-genotype (rs1042522) of the TP53 gene (OR = 1.37–1.83, p < 0.05); children in Southern Siberia, С-allele and СС-genotype of the said gene (OR = 1.55–2.38, p < 0.05). Therefore, the immune profile of children exposed to airborne benzo(a)pyrene at the dose of 7.11•10-3 µg/(kg•day) in Northern Siberia bears some signs of activated apoptosis (p53) and specific sensitization (IgG to benzo(a)pyrene) associated with G-allele and GG-genotype of the TP53 gene (rs1042522) (OR = 1.37–1.83, p < 0.05). These identified changes in the immune profile are comparable with effects produced by exposure to airborne benzo(a)pyrene at the dose of 86.46•10-3 µg/(kg•day) in Southern Siberia, which are associated with С-allele and СС-genotype of the same gene (OR = 1.55–2.38, p < 0.05). This confirms a hypothesis that effects of technogenic chemical factors can be modulated by specific climatic conditions in northern areas and a contribution made by genetic predisposition. Their combined effect creates a serious risk of developing impairments in an immune profile (OR = 1.37–1.83, p < 0.05; RR = 1.17; 95 % CI: 1.07–1.27) even under low-dose exposure to airborne benzo(a)pyrene.

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Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts

Cited by 16 publications

References 156 publications

Traffic and Industrial Contributions of Particle-Bound PAHs during an Air Pollution Event in the Metropolitan Area of Medellin-Colombia: Inhalation Intake Risk during Pregnancy

Traffic and Industrial Contributions of Particle-Bound PAHs during an Air Pollution Event in the Metropolitan Area of Medellin-Colombia: Inhalation Intake Risk during Pregnancy

Polycyclic Aromatic Hydrocarbons’ Impact on Crops and Occurrence, Sources, and Detection Methods in Food: A Review

Polymorphism of TP53 (rs1042522) gene and peculiarities of the immune profile in children exposed to airborne benzo(a)pyrene

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