Effects of polycyclic aromatic hydrocarbons on gestational hormone production in a placental cell line: Application of passive dosing to in vitro tests

Valderrama, Jhon Fredy Narváez; Gil, Vanessa Correa; B, Viviana Alzate; Tavera, Edison Andrés; Noreña, Edgar; Porras, Jazmín; Quintana-Castillo, Juan Carlos; L, Juan José García; P, Francisco José Molina; Ramos-Contreras, Carlos; Sanchez, Julio Bueno

doi:10.1016/j.ecoenv.2022.114090

Cited by 9 publications

(3 citation statements)

References 36 publications

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“…At a global scale, the PM2.5 and the airborne PAHs have been linked with an increasing of the missed abortion rate [27]. Our previous study found that a mixture of PAH congeners associated with PM2.5 in the MAMC (see Figure 3), such as ANT, FLU, PYR, and BaP at low levels, may affect gestational hormone production, such as progesterone and β-hCG in a placental cell line, potentially explaining placental dysfunction and adverse pregnancy outcomes [32]. Certain PAHs associated with PM2.5, such as BaP, PYR, FLU, and ANT, were shown to induce hormone disorders in a placental cell line in that previous study [32].…”

Section: Discussionmentioning

confidence: 98%

“…Our previous study found that a mixture of PAH congeners associated with PM2.5 in the MAMC (see Figure 3), such as ANT, FLU, PYR, and BaP at low levels, may affect gestational hormone production, such as progesterone and β-hCG in a placental cell line, potentially explaining placental dysfunction and adverse pregnancy outcomes [32]. Certain PAHs associated with PM2.5, such as BaP, PYR, FLU, and ANT, were shown to induce hormone disorders in a placental cell line in that previous study [32]. While this is a cellular model, similar pathways linking miscarriage to air pollution exposure have been reported [33].…”

Section: Discussionmentioning

confidence: 99%

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Traffic and Industrial Contributions of Particle-Bound PAHs during an Air Pollution Event in the Metropolitan Area of Medellin-Colombia: Inhalation Intake Risk during Pregnancy

Narváez-Valderrama,

Alzate-B,

Correa-Gil

et al. 2024

Atmosphere

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Air pollution includes particle-bound polycyclic aromatic hydrocarbons (PAHs), which eventually reach the placenta, triggering adverse perinatal outcomes through long-term exposure. Lately, air pollution has increased over the Metropolitan Area of Medellin-Colombia (MAMC), but its effects on pregnancy are still unknown. In this research, a real-time analysis of total airborne PAHs was made using a photoelectric sensor for residential places influenced by the industrial and traffic sources affecting the southern and northern MAMC during the second peak of the bimodal tendency for PM2.5 emissions in this region. Additionally, individual PAHs were analyzed by GC/MS coupled with pressurized hot water extraction methodology. The data were applied using an inhalation intake model to assess pregnancy exposure. The average concentration of PAHs in the southern MAMC was three times higher than in the northern MAMC, where the missed abortion rate has been 1.4 times higher according to the database. Previous research indicates that PAHs act as endocrine-disrupting chemicals (EDCs) during pregnancy and that even heavy congeners could reside in umbilical cord blood. Finally, the annual series of missed abortion rates in the MAMC exhibited a significant correlation with the annual average levels of PM2.5, which were associated with PAHs through correlation analysis (r2 = 0.69, p < 0.01). While this significant correlation does not imply causality, our results suggest an important connection between both variables, opening a gap for a deeper understanding of how regions with high PAH convergence influence the missed abortion rates in MAMC.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Traffic and Industrial Contributions of Particle-Bound PAHs during an Air Pollution Event in the Metropolitan Area of Medellin-Colombia: Inhalation Intake Risk during Pregnancy

Narváez-Valderrama,

Alzate-B,

Correa-Gil

et al. 2024

Atmosphere

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“…Therefore, OPs may be transformed in reservoirs and studies about the risk assessment for complex degraded fractions of pesticides over aquatic species and even endocrine disruptor effects should be performed in future studies. Some pollutants may affect reproductive hormones even at low levels (Narvaez Valderrama et al, 2022)…”

Section: Discusionmentioning

confidence: 99%

Biodegradación de clorpirifos por medio de microbiota autoctona de un embalse de agua potable

Narvaez Valderrama,

Sepúlveda Sanchez,

Argoti Ospina

et al. 2024

reveia

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El clorpirifos, es un plaguicida aplicado ampliamente en actividades agrícolas.Esta sustancia, puede ser transportado desde el suelo a las aguas superficiales e inclusoa las subterráneas por medio de lixiviación y escorrentía debido a las interaccionesfisicoquímicas suelo-sustancia. Una vez en los compartimentos ambientales, elclorpirifos puede transformarse mediante reacciones bióticas y abióticas, lo queaumenta los efectos complejos y múltiples sobre la biota. Asi, la biodegradación esuna reacción natural importante que reduce los niveles ambientales de plaguicidas ypor lo tanto, la microbiota autóctona con alto potencial de biotransformación podríaestar relacionada con la persistencia y dinámica del clorpirifos. En este studio, seamnalizó la biodegradación de clorpirifos por medio de microbiota autóctona enagua natural de un embalse. En las muestras se detectaron indicadores bacterianoscomo Pseudomonas aeruginosa, Escherichia coli y coliformes totales utilizandomedio de cultivo selectivo y medio de cultivo diferencial, tales como Pseudalert yColilert. En medio acuoso con microbiota autóctona, el clorpirifos se transformó en3,5,6-tricloro-2-piridinol (TCP), y la vida media se estimó en 10,2 h. Los resultadosmostraron que estos indicadores bacterianos en el embalse pueden reducir losniveles de clorpirifos en el cuerpo de agua, pero aún se desconoce si el metabolitoTCP emerge en el cuerpo de agua con efectos acuáticos.

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Exploring the endocrine disrupting potential of a complex mixture of PAHs in the estrogen pathway in Oreochromis niloticus hepatocytes

de Souza,

da Luz,

Roque

et al. 2024

Aquatic Toxicology

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Effects of polycyclic aromatic hydrocarbons on gestational hormone production in a placental cell line: Application of passive dosing to in vitro tests

Cited by 9 publications

References 36 publications

Traffic and Industrial Contributions of Particle-Bound PAHs during an Air Pollution Event in the Metropolitan Area of Medellin-Colombia: Inhalation Intake Risk during Pregnancy

Traffic and Industrial Contributions of Particle-Bound PAHs during an Air Pollution Event in the Metropolitan Area of Medellin-Colombia: Inhalation Intake Risk during Pregnancy

Biodegradación de clorpirifos por medio de microbiota autoctona de un embalse de agua potable

Exploring the endocrine disrupting potential of a complex mixture of PAHs in the estrogen pathway in Oreochromis niloticus hepatocytes

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