Effects of polycyclic aromatic hydrocarbon exposure and miRNA variations on peripheral blood leukocyte DNA telomere length: A cross-sectional study in Henan Province, China

Duan, Xiaoran; Zhang, Daping; Wang, Sihua; Feng, Xiaolei; Wang, Tuanwei; Wang, Pengpeng; Ding, Mingcui; Zhang, Hui; Liu, Bin; Wei, Wan; Acquaye, Reuben Mensah; Yao, Wu; Cui, Liuxin; Zhou, Xiaoshan; Wang, Wei; Yang, Yongli

doi:10.1016/j.scitotenv.2019.135600

Cited by 22 publications

(7 citation statements)

References 45 publications

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“…Table S6 compares the levels of OH-PAHs in the urine of workers from various sites. Our study revealed significantly higher OH-PAH concentrations in workers compared to Shanxi ,, and Yunnan, but much lower than Hubei ,, and Henan . Additionally, OH-PAH levels in our study exceeded those in other occupational exposure workers in China, such as e-waste workers, diesel engine testing workers, and waste collectors .…”

Section: Resultscontrasting

confidence: 57%

“…13 Pyr) comprises a larger proportion in coking plant workers than normal residents. 13,14 The levels of OH-PAHs in coke oven workers vary regionally in China, 13 OH-PAH concentrations are much higher in workers from Henan 15 and Hubei 10,16 than in those from Shanxi 17,18 and Yunnan. 11 In terms of occupational position, workers at the top of coke ovens have higher OH-PAH levels than those at side and bottom of coke ovens.…”

Section: Introductionmentioning

confidence: 99%

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Coking-Produced Aromatic Compounds in Urine of Exposed and Nonexposed Populations: Exposure Levels, Source Identification, and Model-Based Health Implications

Li,

Yao,

et al. 2023

Environ. Sci. Technol.

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Coking contamination in China is complex and poses potential health risks to humans. In this study, we collected urine samples from coking plant workers, nearby residents, and control individuals to analyze 25 coking-produced aromatic compounds (ACs), including metabolites of polycyclic aromatic hydrocarbons (PAHs) and their derivatives, chlorophenols, and nitrophenols. The median concentration of total ACs in urine of workers was 102 μg·g–1 creatinine, significantly higher than that in the other two groups. Hydroxy-PAHs and hydroxy hetero-PAHs were the dominant ACs. Workers directly exposed from coking industrial processes, i.e., coking, coal preparation, and chemical production processes, showed higher concentrations of hydroxy-PAHs and hydroxy hetero-PAHs (excluding 5-hydroxyisoquinoline), while those from indirect exposure workshops had higher levels of other ACs, indicating different sources in the coking plant. The AC mixture in workers demonstrated positive effects on DNA damage and lipid peroxidation with 5-hydroxyisoquinoline and 3-hydroxycarbazole playing a significant role using a quantile g-computation model. Monte Carlo simulation revealed that coking contamination elevated the carcinogenic risk for exposed workers by 5-fold compared to controls with pyrene, pentachlorophenol, and carbazole contributing the most, and workers from coking process are at the highest risk. This study enhances understanding of coking-produced AC levels and provides valuable insights into coking contamination control.

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Section: Resultscontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Coking-Produced Aromatic Compounds in Urine of Exposed and Nonexposed Populations: Exposure Levels, Source Identification, and Model-Based Health Implications

Li,

Yao,

et al. 2023

Environ. Sci. Technol.

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“…Detailed detection methods were described in our previous study. 18 High-performance liquid chromatography (HPLC) was used to detect the concentrations of four OH-PAHs [1-hydroxypyrene (1-OHPYR) and 1-hydroxynathalene (1-OHNAP), 2-hydroxynathalene (2-OHNAP), and 3-hydroxyphenanthrene (3-OHPHE)] in urine, as described in the previous study. 19…”

Section: Determination Of Environmental Exposurementioning

confidence: 99%

Genetic polymorphisms of metabolic enzyme genes associated with leukocyte mitochondrial DNA copy number in PAHs exposure workers

Duan

Zhang

et al. 2021

Cancer Reports

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Background: Polycyclic aromatic hydrocarbons (PAHs) exposure had been reported to be a risk factor of mtDNAcn in our early study. However, the effect of metabolic enzymes' genetic polymorphisms on mtDNAcn in PAHs-Exposure workers has not been fully evaluated.Aim: The aim of the study was to explore the effect of metabolic enzymes' genetic polymorphisms on mtDNAcn in PAHs-Exposure. Methods and Results:We investigated the effects of metabolic enzymes' genetic polymorphisms on mtDNAcn among 544 coke oven workers and 238 office staffs.The mtDNAcn of peripheral blood leukocytes was measured using the Real-time quantitative polymerase chain reaction (PCR) method. PCR and restriction fragment length was used to detect five polymorphisms in GSTT1, GSTM1, GSTP1 rs1695, CYP2E1 rs6413432, and CYP2E1 rs3813867. The mtDNAcn in peripheral blood leukocytes was significantly lower in the exposure group than that in the control group (p < .001). The 1-OHPYR had an increasing trend with the genotypes AA!AG ! GG of GSTP1 rs1695 in the control group. Generalized linear model indicated that the influencing factors of mtDNAcn were PAHs-exposure [β (95% CI) = −0.420 (−0.469, −0.372), p < .001], male [β (95% CI) = −0.058 (−0.103, −0.012), p = .013], and AA genotype for GSTP1 rs1695 [β (95% CI) = −0.051 (−0.095, −0.008), p = .020]. Conclusion:The individuals carrying the AA genotype of GSTP1 rs1695 may have a lower mtDNAcn due to their weaker detoxification of PAHs.

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“…In the second mechanism, rs353291 might indirectly cause abnormalities in the length of telomeres. GG-genotype individuals were found to have longer telomere when compared with those who had AA or AG genotypes (P = 0.005) (Duan et al, 2020). Both shorter and longer telomere can lead to cancers (Aviv et al, 2017;McNally et al, 2019).…”

Section: Effect Of Rs353291 (A/g) On Pri-mir-145 In Breast Tumorigenesismentioning

confidence: 94%

Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer

et al. 2020

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MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and the potential mechanisms of how these miR-SNPs develop the risk of the disease were discussed.

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Effects of polycyclic aromatic hydrocarbon exposure and miRNA variations on peripheral blood leukocyte DNA telomere length: A cross-sectional study in Henan Province, China

Cited by 22 publications

References 45 publications

Coking-Produced Aromatic Compounds in Urine of Exposed and Nonexposed Populations: Exposure Levels, Source Identification, and Model-Based Health Implications

Coking-Produced Aromatic Compounds in Urine of Exposed and Nonexposed Populations: Exposure Levels, Source Identification, and Model-Based Health Implications

Genetic polymorphisms of metabolic enzyme genes associated with leukocyte mitochondrial DNA copy number in PAHs exposure workers

Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer

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