2017
DOI: 10.1021/acs.est.7b01538
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Effects of Polychlorinated Biphenyls (PCBs) and Their Hydroxylated Metabolites (OH-PCBs) on Arabidopsis thaliana

Abstract: Plants metabolize polychlorinated biphenyls (PCBs) into hydroxylated derivatives (OH-PCBs), which are sometimes more toxic than the parent PCBs. The objective of this research was to compare the toxicity of a suite of PCBs and OH-PCBs toward the model plant, Arabidopsis thaliana. While parent PCBs and higher-chlorinated OH-PCBs exhibited a low or nondetectable toxicity, lower-chlorinated OH-PCBs significantly inhibited the germination rate and plant growth, with inhibition concentration 50% (IC50) ranging from… Show more

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Cited by 35 publications
(36 citation statements)
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“…Understanding the effects of PCBs and OH-PCBs on plants is significant because plants are the basis of the terrestrial food web and can be used for soil remediation (i.e., phytoremediation). In a prior publication, we reported that a suite of lowerchlorinated OH-PCBs were highly toxic for the model plant, Arabidopsis thaliana, while most parent PCBs did not show significant effects (Subramanian et al, 2017). Gene expression analysis using 2,5-dichlorobiphenyl (2,5-DCB) and its OH-derivative, 4'-OH-2,5-DCB, showed that the parent compound -unlike the OH-derivative -induced multiple xenobiotic response genes, such as cytochrome P-450 and glutathione Stransferases, potentially involved in the PCB metabolism, which may explain the lower phytotoxicity of PCBs as compared with their OH-derivatives.…”
Section: Introductionmentioning
confidence: 93%
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“…Understanding the effects of PCBs and OH-PCBs on plants is significant because plants are the basis of the terrestrial food web and can be used for soil remediation (i.e., phytoremediation). In a prior publication, we reported that a suite of lowerchlorinated OH-PCBs were highly toxic for the model plant, Arabidopsis thaliana, while most parent PCBs did not show significant effects (Subramanian et al, 2017). Gene expression analysis using 2,5-dichlorobiphenyl (2,5-DCB) and its OH-derivative, 4'-OH-2,5-DCB, showed that the parent compound -unlike the OH-derivative -induced multiple xenobiotic response genes, such as cytochrome P-450 and glutathione Stransferases, potentially involved in the PCB metabolism, which may explain the lower phytotoxicity of PCBs as compared with their OH-derivatives.…”
Section: Introductionmentioning
confidence: 93%
“…A. thaliana, ecotype Columbia (Col-0/Redei-L211497, Ohio State University, Columbus, OH) was grown as we described in Subramanian et al (2017). In short, surface-sterilized seeds were germinated in Petri dishes containing semi-solid, half-strength Murashige & Skoog (MS) medium (0.3% sucrose) supplemented with increasing concentrations of 2,5-DCB, 2'-OH-, 3'-OH-, and 4'-OH-2,5-DCBs.…”
Section: Toxicity Testsmentioning
confidence: 99%
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“…However, most plant species cannot absorb and accumulate lipophilic PCBs through their root systems. Some congeners and their metabolites are toxic to plants species (Subramanian et al 2017). Researchers report successful use of plants as passive biomonitors of PCBs in ambient air as shown by 25 years of PCB biomonitoring by the Bavarian EPA (Weber et al 2017).…”
mentioning
confidence: 99%