Effects of polybrominated diphenyl ethers on thyroid hormone, neurodevelopment and fertility in rodents and humans

Czerska, Marta; Zieliński, Marek; Kamińska, Joanna; Ligocka, Danuta

doi:10.2478/s13382-013-0138-7

Cited by 48 publications

(29 citation statements)

References 32 publications

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“…There is a growing literature linking PBDE exposure to thyroid disruption (Czerska et al 2013; Linares et al 2015), including previous work in the current study cohort (Makey et al 2015). Therefore, it is important to consider potential confounding and/or modification by PBDEs when assessing associations between TPHP exposure and thyroid function.…”

Section: Introductionmentioning

confidence: 95%

Associations between urinary diphenyl phosphate and thyroid function

Preston

McClean

Henn

et al. 2017

Environment International

115

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Triphenyl phosphate (TPHP) is a commonly used organophosphate flame retardant and plasticizer with widespread human exposure. Data on health effects of TPHP are limited. Recent toxicological studies suggest TPHP may alter thyroid function. We used repeated measures to assess the temporal variability in urinary concentrations of the TPHP metabolite, diphenyl phosphate (DPHP), and to examine relationships between DPHP concentrations and thyroid hormones. We sampled 51 adults at months 1, 6, and 12 from 2010-2011. Urine samples were analyzed for DPHP. Serum samples were analyzed for free and total thyroxine (fT4, TT4), total triiodothyronine (TT3), and thyroid stimulating hormone (TSH). We assessed variability in DPHP using intraclass correlation coefficients (ICCs) and kappa statistics. We used linear mixed-effects models to examine associations between DPHP and thyroid hormones. DPHP was detected in 95% of urine samples. Mean DPHP concentrations were 43% higher in women than men. DPHP showed high within-subject variability (ICC range, 0.13-0.39; Kappa range, 0.16-0.39). High versus low (≥2.65 vs. <2.65 ng/mL) DPHP in all participants was associated with a 0.43 μg/dL (95% confidence interval: 0.15, 0.72) increase in mean TT4 levels. In sex-stratified analyses, high versus low DPHP was associated with a 0.91 μg/dL (95% CI: 0.47, 1.36) increase in mean TT4 in women. The association was attenuated in men (βeta= 0.19; 95% CI: -0.15, 0.52). We found no significant associations between DPHP and fT4, TT3, or TSH. We found evidence that TPHP exposure may be associated with increased TT4 levels, especially in women.

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Section: Introductionmentioning

confidence: 95%

Associations between urinary diphenyl phosphate and thyroid function

Preston

McClean

Henn

et al. 2017

Environment International

115

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“…Exposure to PBDEs during pregnancy can lead to slower mental and psychomotor development in infants (Czerska et al 2013). Additionally, postnatal exposure has been recognized as having long-term detrimental neurotoxic effects, e.g., in spatial learning and memory (Reverte et al 2013).…”

Section: Polybrominated Diphenyl Ethers (Brominated Flame Retardants;mentioning

confidence: 99%

Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males

Kern¹,

Homme

King³

et al. 2017

Acta Neurobiologiae Experimentalis

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The prevalence of neurodevelopmental disorders (NDs), including autism spectrum disorder, attention-deficit/hyperactivity disorder, tic disorder, obsessive-compulsive disorder, and emotional disturbances, has increased notably in the past few decades.To date, debate continues as to the origins of NDs. Increases in widespread exposure to and bioaccumulation of chemical neurotoxicants have paralleled the upsurge in NDs, and are suggested to be causal agents for NDs. One consistent aspect of NDs is the male preponderance. This review considers the issue of male preponderance by reviewing the gender-specific neurotoxic effects of recognized neurotoxicant chemicals to assess their possible etiology in NDs. This investigation consisted of a systematic literature review of original studies published from 1970-2016 on suspected neurotoxicants, to examine whether they have a disproportionate adverse effect based on gender. Based on that review, the neurotoxicants exhibiting consistent gender-specific effects, with exposed males being more affected (than similarly exposed females), were: lead, Thimerosal/ethylmercury, some organochlorine pesticides (e.g., dieldrin, endosulfan, and heptachlor), and air pollution. The next group identified were neurotoxicants exhibiting gender-specific neurotoxic effects, with males being somewhat (but not consistently) more affected than females: mercury vapor, polychlorinated biphenyls (PCBs), and organophosphate pesticides. Finally, there was a group of studies in which the neurotoxicants exhibited apparent gender-related neurotoxic effects but failed to show whether exposed males were consistently more affected than females: inorganic mercury salts, methylmercury species, and certain endocrine disruptors (e.g., phthalates and BPA). The overall conclusion from the studies reviewed was that the brain in males is more vulnerable to many toxic exposures than it is in females. Evidence suggests that the reasons for the male brain being more vulnerable include:(1) greater glutathione availability in females; (2) greater sulfate-based detoxification capacity in females; (3) potentiating effects of co-exposure to neurotoxicants and testosterone; (4) greater neuroinflammatory response in males; (5) reduced vulnerability to oxidative stress in females; and (6) neuroprotective effects of female hormones (estrogen and progesterone), especially in the reduction of inflammation and oxidative stress.

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“…The PBDEs can be bioaccumulate into the environment and biomagnify through the food web . There are reports of the presence of PBDEs in human samples such as the serum, breast milk, hair, and cord blood samples, which can produce adverse effects on nervous, reproductive, and endocrine systems …”

Section: Introductionmentioning

confidence: 99%

Enzymatic Digestion Coupled to Surfactant‐Assisted Dispersive Liquid‐Liquid Microextraction: A Mild Approach for Determining Polybrominated Diphenyl Ethers in Human Hair Sample

et al. 2020

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Enzymatic digestion, coupled to surfactant assisted‐dispersive liquid‐liquid microextraction (ED‐SA‐DLLME), is proposed as a mild innovative sample preparation methodology to determine polybrominated diphenyl ethers (PBDEs) in human hair samples by gas chromatography. The sodium dodecyl sulfate as a promoting agent in the ED stage also acts as a dispersive agent in DLLME, providing an advantageous synergy between sample preparation stages. Experimental variables of the ED‐SA‐DLLME were optimized using a multivariate method. The optimal experimental conditions were: proteinase K 0.96 U mL−1, SDS 1% (w/v), 37 °C, and 60 min for ED; and 50 μL tetrachloroethylene for SA‐DLLME. The notable analytical figures of merit showed LOQ in the range of 30–430 pg g−1, relative standard deviations <9%, and recoveries of 90–94%. The PBDEs were found in human hair samples <0.07 ng g−1.

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Effects of polybrominated diphenyl ethers on thyroid hormone, neurodevelopment and fertility in rodents and humans

Cited by 48 publications

References 32 publications

Associations between urinary diphenyl phosphate and thyroid function

Associations between urinary diphenyl phosphate and thyroid function

Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males

Enzymatic Digestion Coupled to Surfactant‐Assisted Dispersive Liquid‐Liquid Microextraction: A Mild Approach for Determining Polybrominated Diphenyl Ethers in Human Hair Sample

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