Effects of Poly(N-isopropylacrylamide) (PNIPAAm) on the Conformational Change of Poly(N 5-hydroxyalkyl glutamine) (PHAG) in PHAG-PNIPAAm Block Copolymer with Temperature

Cheon, Jae-Bok; Kim, B. C.; Park, Young Hyun; Park, J. S.; Moon, Janghyuk; Nahm, Joong Hee; Cho, C. S.

doi:10.1002/1521-3935(20010201)202:3<395::aid-macp395>3.0.co;2-s

Cited by 10 publications

(7 citation statements)

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“…It is essential to find suitable thermally sensitive carriers for encapsulating anticancer drugs in terms of practical applications of thermal targeting treatments. The field of temperature-sensitive polymeric nanoparticles has been dominated by poly(N-isopropylacrylamide) (PNIPAAm), because of its sharp, almost discontinuous volume phase transition corresponding to an LCST of about 32 • C [8,12,[18][19][20][21][22][23][24]. Recently, attention has been paid to poly(N,N-diethylacrylamide) (PDEAAm) as an alternative thermo-sensitive polymer to PNIPAAm [25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Novel thermo-sensitive core–shell nanoparticles for targeted paclitaxel delivery

Pan²,

Zhang

et al. 2009

Nanotechnology

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Novel thermo-sensitive nanoparticles self-assembled from poly(N,N-diethylacrylamide-co-acrylamide)-block-poly(gamma-benzyl L-glutamate) were designed for targeted drug delivery in localized hyperthermia. The lower critical solution temperature (LCST) of nanoparticles was adjusted to a level between physiological body temperature (37 degrees C) and that used in local hyperthermia (about 43 degrees C). The temperature-dependent performances of the core-shell nanoparticles were systemically studied by nuclear magnetic resonance (NMR), circular dichroism (CD), fluorescence spectroscopy, dynamic light scattering (DLS), and atom force microscopy (AFM). The mean diameter of the nanoparticles increased slightly from 110 to 129 nm when paclitaxel (PTX), a poorly water-soluble anti-tumor drug, was encapsulated. A stability study in bovine serum albumin (BSA) solution indicated that the PTX loaded nanoparticles may have a long circulation time under physiological environments as the LCST was above physiological body temperature and the shell remained hydrophilic at 37 degrees C. The PTX release profiles showed thermo-sensitive controlled behavior. The proliferation inhibiting activity of PTX loaded nanoparticles was evaluated against Hela cells in vitro, compared with Taxol (a formulation of paclitaxel dissolved in Cremophor EL and ethanol). The cytotoxicity of PTX loaded nanoparticles increased obviously when hyperthermia was performed. The nanoparticles synthesized here could be an ideal candidate for thermal triggered anti-tumor PTX delivery system.

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Section: Introductionmentioning

confidence: 99%

Novel thermo-sensitive core–shell nanoparticles for targeted paclitaxel delivery

Pan²,

Zhang

et al. 2009

Nanotechnology

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“…PBLG is able to form a stable α-helix with the degree of polymerization (DP) > 8–12; − therefore, it is necessary to prepare PBLG with DP > 12 to ensure the helical structure of the macromolecular cross-linker based on PBLG. Poly(3-propyl-acrylate-glutamine) (acryl-PHPG) was synthesized by ring-opening polymerization of NCA using hexylamine as the initiator and aminolysis, , followed by acrylation of the hydroxy group (Scheme ). Similarly, acryl- dl -PHPG was prepared by random copolymerization of γ-benzyl- l -glutamate and γ-benzyl- d -glutamate NCA (molar ratio = 1:1) and subsequent aminolysis and acrylation.…”

Section: Resultsmentioning

confidence: 99%

Secondary Structure-Governed Polypeptide Cross-Linked Polymeric Hydrogels

Chen

Lan

et al. 2019

Chem. Mater.

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Modulation of the secondary structures of peptides gives rise to a range of natural peptide-based soft materials with outstanding mechanical properties. Here, we discuss detailed insights on how the secondary structure of tailor-made polypeptides governs the mechanical properties of polymeric hydrogels. To this end, we developed a series of polymeric hydrogels cross-linked by poly(3-propyl-acrylate-glutamine) with tailorable secondary structuresα-helices and random coils. Interestingly, the hydrogels cross-linked by the α-helical cross-linker exhibit a high tensile strength and toughness because of the cooperative intramolecular hydrogen bonding along the polypeptide backbone. Furthermore, the α-helices endow the hydrogels with high resilience and rapid recovery because of their reversible cooperative hydrogen bonding. In contrast, the hydrogels cross-linked by the random coil cross-linker show inferior tensile strength and toughness. Our study establishes quantitative nanoscale/macroscale structure–property relationships in polymeric hydrogels and has important implications for the rational design of soft materials using polypeptides with a specific secondary structure.

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“…Cho et al prepared block copolymers of a hydrophobic poly(γ-benzyl- l -glutamate) (PBLG) block and a hydrophilic poly( N -isopropylacrylamide (PNIPAAm) block, which yielded micelles in an aqueous environment with PBLG forming the core. A series of this block copolymer in which part of the benzyl glutamate moieties were derivatized to N 5 -hydroxyalkylglutamate was prepared as well. , Poly(2-ethyl-2-oxazoline)- block -PBLG (PEtOZ-PBLG) assembled into spherical micelles in water but displayed a diverse array of aggregate morphologies in solvents in which the PBLG-block assumed a rodlike shape …”

Section: Polymer Micellesmentioning

confidence: 99%

Biohybrid Polymer Capsules

et al. 2009

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Artificial nano-and microcapsules that seek to mimic their natural counterparts can be constructed in different ways, leading to a variety of properties, as will be discussed in this review. [6][7][8] Enzymatic conversions can take place in the lumen of such capsules, and their membranes can be used to confine and tune reaction pathways. Synthetic capsules are also attracting a lot of attention because of their promising applications in the controlled release of pharmaceuticals. Capsules that bear recognition elements have been targeted to specific tissues or organs, providing a desirable vehicle for the aforementioned release of drugs. 9 For a chemist, the successful exploitation of capsules begins with their tailormade design and synthesis, for which cells and their organelles are the primary source of inspiration. In order to be able to do so, one needs insight into the design principles of nature to endow function to a molecule and to direct its self-assembly to a preset architecture. Although spectacular progresshasbeenmadeinthefieldofbioinspiredself-assembly, [10][11][12][13] unfortunately, the construction of an artificial cell is still not much more than a fantasy. Fortunately, more simple systems such as micelles, vesicles, and other assemblies of molecules may already partly solve the problem by providing a capsule that can be geared toward a desired application, e.g. the controlled release of drugs, as was demonstrated in the literature already quite a long time ago. [14][15][16] The view of life as being the result of a nanoscale phenomenon 17 is of more recent date and should rouse the interest in capsules for any chemist. Stijn F. M. van Dongen (group, center) was born in Goirle, The Netherlands, and studied chemistry at the Radboud University Nijmegen. He received his master's degree in 2006 after traineeships in the physical organic chemistry group of Prof. R. J. M. Nolte and the synthetic biology group of Prof. D. M. Hilvert at the ETH in Zu ¨rich, Switzerland. He is currently a Ph.D. student in the group of Profs.' R. J. M. Nolte and J. C. M. van Hest, working on the exploration of polymersomes as nanoreactors in a biological setting. Hans-Peter M. de Hoog (group, second from left) was born in Arnhem, The Netherlands, and graduated in chemistry at Utrecht University in 1998, specializing in the analysis of complex biomolecules. After a short stay at The Netherlands Organisation for Applied Scientific Research (TNO), he moved to the Radboud University Nijmegen in 2005 to pursue a Ph.D. in supramolecular and physical organic chemistry in the group of Prof. R. J. M. Nolte and J. J. L. M. Cornelissen. His research involves a collaborative project with Delft University of Technology (Prof. I. W. C. E. Arends) on the applicationdriven encapsulation of enzymes in polymersomes. Ruud J. R. W. Peters (group, right) obtained his bachelor's degree in molecular life sciences at the Radboud University Nijmegen in 2008. He is currently performing his master's research on the interactions between polymersomes a...

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Effects of Poly(N-isopropylacrylamide) (PNIPAAm) on the Conformational Change of Poly(N 5-hydroxyalkyl glutamine) (PHAG) in PHAG-PNIPAAm Block Copolymer with Temperature

Cited by 10 publications

References 10 publications

Novel thermo-sensitive core–shell nanoparticles for targeted paclitaxel delivery

Novel thermo-sensitive core–shell nanoparticles for targeted paclitaxel delivery

Secondary Structure-Governed Polypeptide Cross-Linked Polymeric Hydrogels

Biohybrid Polymer Capsules

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