Effects of Platycodon Grandiflorum Feeding on Serum and Liver Lipid Concentrations in Rats with Diet-Induced Hyperlipidemia.

Abstract

SummaryTo study the effect of Platycodon grandiflorum (P. g.) feed ing on serum and liver lipid concentrations, diet-induced hyperlipidemic rats were fed diets containing 5% and 10% P. g, powder for 3 weeks. The P. g. feeding markedly decreased both serum and liver lipid concentrations in hyperlipidemic rats. Especially, 5% P. g. diet significantly decreased the concentrations of total cholesterol and triglycerides in serum and liver as compared with those of the hyperlipidemic control group. Dietary P. g. also induced a reduction in low-density lipoprotein (LDL)-cholesterol as well as an increase in the concentration of high-density lipoprotein (HDL)-cholesterol in serum. Furthermore, the atherogenic index was also low in rats fed P. g. diet. These results indicated that dietary P. g. may have a beneficial effect on preventing hypercholesterolemia and hyperlip idemia.

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

“…Some evidence shows that Platycodi radix extracts possess some health benefits such as the improvement of hypercholesterolemia and hyperlipidemia. 78 The saponin-rich fraction of Platycodi radix has an inhibitory effect on HPL and this seems to correlate with anti-obesity actions. [79][80][81][82] Among the various saponins, platycodin D possesses the strongest HPL inhibitory activity with a Ki of 0.18 mM.…”

Seasonal Variation of Saponin Contents in Platycodon grandiflorum

“…However, the present study, platycodon saponin content from several samples showed that the wild roots of platycodon contained 7.3-11.8% saponins; cultivated roots had 1.7-14% saponins 15 . Whereas the level of crude saponins in platycodon was said to be 2% in a medicinal grade material in Korea reported by Kim et al, 1995 etc 16 . In Korea, it is noted that the content of saponins varies with respect to the climatic condition than in China.…”

“…The content of 4 major saponins varied largely among different growing times indicates that climatic and edaphic factors are directly involved for saponin content. The variation of saponin content varied with reagions, environmental conditions were reported by several investigation [15][16][17][18] . Those findings are directly coincided with our findings.…”

Hepatoprotective and Anti-Hepatitis C Viral Activity of Platycodon grandiflorum Extract on Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice

“…On the basis of fingerprint analysis of BC703, it contained a large group of oleanane-type triterpenoid saponins, such as deapioplatycoside E, platycoside E, platycodinD 3 (Fig. 1).…”

“…It was reported to contain a lot of carbohydrates (at least 90%), protein (2.4%), lipids (0.1%) and ash (1.5%) ( 1 ). Recently, it has been reported that the polysaccharides isolated from the root of Platycodon grandiflorum prevent obesity, hypecholesterolemia, hypertension, diabetes, immune modulation and hyperlipidemia (2)(3)(4)(5). In addition, triterpenoid saponins in the roots of the Platycodon grandiflorum are believed to prevent chemical-induced hepatotoxicity ( 6,7 ).…”