Effects of Platostoma palustre ethanolic extracts and commercial herbal tea on the cell viability of colorectal cancer cells

Lin, Yi; Chen, Chia-Chi; Chen, Hsiao-Yun; Hung, Ying-Ching; Chi, Tzu-Yun; Lin, Chia-Yu; Chen, Guanhong; Huang, Ping-Min; Wang, Yapeng; Wu, Tsung‐Han; Lu, Yen-Jung; Chiu, Chien-Chao; Chiu, Ching-Feng; Chiu, Hsuan-Wen; Wei-Huang, Tsai; Hung, Shao-Wen

doi:10.30574/gscbps.2022.18.2.0086

Cited by 2 publications

(4 citation statements)

References 11 publications

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“…Ethanolic extracts of M. chinensis, at concentrations of 1560-100,000 µg/mL and 390-3130 µg/mL, showed significant inhibition effects against the viability of CT-26 (colorectal cancer cell line) and HT-29 (Human colon cancer cells) colorectal cancer cell lines, respectively [79]. The protective effect of a methanolic extract of M. chinensis on human leukemia cancer cells was reported by Huang et al [28].…”

Section: Cancer and Toxicity Studiesmentioning

confidence: 80%

Functionality and Health-Promoting Properties of Polysaccharide and Plant-Derived Substances from Mesona chinensis

Seah,

Siripongvutikorn,

Wichienchot

et al. 2024

Foods

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Mesona chinensis, in Thai called Chao Kuay and in Chinese Hsian-tsao, belongs to the Lamiaceae family. This herbal plant grows widely in Southern China, Taiwan (China), Malaysia, the Philippines, Indonesia, Vietnam, and Thailand. The Mesona plant is used to make functional products such as drinks and soft textured sweet treats, and also traditional medicine, to treat heat stroke, high blood pressure, heart attack, high blood sugar, hepatic diseases, colon diseases, inflammatory conditions, and to alleviate myalgia. The proximate composition of M. chinensis is a mixture of protein, fat, fiber, ash, and minerals. The main biological compounds in M. chinensis extracts are polysaccharides, terpenoids, flavonoids, and polyphenols, with wide-ranging pharmacological properties including antioxidant, antidiabetic, antilipidemic, carcinoma-inhibitory, renal-protective, antihypertensive, DNA damage-protective, and anti-inflammatory effects. This review investigated the proximate composition, polysaccharide type, and pharmacological properties of M. chinensis extracts. Phytochemical properties enhance the actions of the gut microbiota and improve health benefits. This review assessed the functional and medicinal activities of M. chinensis extracts. Future studies should further elucidate the in vitro/in vivo mechanisms of this plant extract and its impact on gut health.

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Section: Cancer and Toxicity Studiesmentioning

confidence: 80%

Functionality and Health-Promoting Properties of Polysaccharide and Plant-Derived Substances from Mesona chinensis

Seah,

Siripongvutikorn,

Wichienchot

et al. 2024

Foods

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“…The 60% Mesona procumbens ethanolic extracts exhibited higher antioxidant activities that possessed a protective capability for the biological membrane system to prevent and treat oxidative stress-related disorders [13][14][15][16]. According to our previous results [6][7], 90% Platostoma palustre ethanolic extracts were detected the components. The bio-functional indexes and concentrations of 90% Platostoma palustre ethanolic extracts were chlorogenic acid (0.30 mg/mg 90% Platostoma palustre ethanolic extracts), caffeic acid (0.70 mg/mg 90% Platostoma palustre ethanolic extracts), rutin (0.80 mg/mg 90% Platostoma palustre ethanolic extracts), astragaloside IV (7.50 mg/mg 90% Platostoma palustre ethanolic extracts), and rosmarinic acid (15.90 mg/mg 90% Platostoma palustre ethanolic extracts).…”

Section: Discussionmentioning

confidence: 99%

“…Platostoma palustre is an annual plant that is mainly distributed in tropical and subtropical regions, including Taiwan, Indonesia, Vietnam, southern China, and Burma [4][5][6][7]. The related food with Platostoma palustre as tea, herbal jelly, and sweet soup with herbal jelly are popular during the summer.…”

Section: Introductionmentioning

confidence: 99%

“…Platostoma palustre has been used as folk medicine. Platostoma palustre has been verified that possessed many functional compounds such as polysaccharides (gum) with a unique aroma and texture, sterol compounds, stigmasterol, α-sitosterol, tripterpene compounds, oleanolic acid, volatile compounds (caryophyllene oxide, α-caryophyllene, eugenol, benzene acetaldehyde, and 2,3-butanedione etc), essential oil (n-hexadecanoic acid, linoleic acid, and linolenic acid), volatile oil (chavibetol, n-hexadecanoic acid, and α-cadinol), and ursolic acid [4][5][6][7][8]. Therefore, theses functional compounds of Platostoma palustre have indicated that many biological effects is effective against and attenuating the metabolic syndrome, heat-shock, hypertension, diabetes, liver disease, muscle and/or joint pains, hyperglycemia, inflammation, oxidant activity, free radical scavenging effects, acute and chronic hepatitis, and caner growth [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Effects of herbal tea (Platostoma palustre) on blood glucose regulation in vivo

Liu¹,

Chi²,

Wang³

et al. 2023

GSC Adv. Res. Rev.

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Platostoma palustre jelly is a traditional food. Platostoma palustre has been used as folk medicine and is effective against heat-shock, hypertension and diabetes. Therefore, the aim of in vivo study was to determine the effects of herbal tea (Platostoma palustre) on blood glucose regulation. The commercial herbal tea (Platostoma palustre) was kindly provided by Yueta Agricultural Biotechnology Inc. Adult male 18 Institute of Cancer Research (ICR) mice [8 weeks old; body weight (BW) between 31-33 g] with specific pathogen-free conditions were used for this study. All ICR mice were divided respectively the normal control group (n = 6), the negative control group (n = 6), and the herbal tea group (n = 6). The ICR mice (the negative control group and the herbal tea group) were intraperitoneally injected with streptozotocin (65 mg/kg BW) and nicotinamide (230 mg/kg BW) for inducing the symptoms of hyperglycemia. In the herbal tea group, the herbal tea (10 mL/kg BW) was administrated to ICR mice by gavage. To monitor the blood glucose levels in ICR mice, blood was obtained from the tail of ICR mice, and blood glucose levels were determined using the external glucometer. Blood glucose measurements were conducted once in ICR mice before the experiment and were detected once per month after the experiment. Additionally, the change of ICR mice’ BW, the blood glucose of ICR mice, and the observation of ICR mice’ behavior were monitored and detected during the experiment. The results of this experiment showed · Weight change: the weight gain of the negative control group and the herbal tea group were significantly lower than those of the normal control group and there was no significant difference between the negative control group and the herbal tea group. · Fasting blood glucose and postprandial blood glucose: the fasting blood glucose of the negative control group was significantly higher than that of the normal control group, while the herbal tea group had a tendency to lower the fasting blood glucose, but there was no significant difference compared with the negative control group. The postprandial blood glucose level results showed that the negative control group was significantly higher than the normal control group. The postprandial blood glucose level of the herbal tea group was between the normal control group and the negative control group at the 4th week administration with the herbal tea. At the 8th week administration with the herbal tea, there was a significant difference compared with the negative control group. · Oral glucose tolerance test (OGTT): 4 to 12 weeks after hyperglycemia was induced, the blood glucose levels of the negative control group at each OGTT test point were significantly higher than those of the normal control group. The blood glucose level at the test point tended to decrease, but there was no significant difference from the negative control group. By calculating the area under the OGTT curve, it was found that the area under the curve of the negative control group was significantly higher than that of the normal control group, while the results of the herbal tea group at the 8th and 12th weeks were significantly lower than those of the negative control group. Taken all results together, the hyperglycemia was successfully induced in the experimental ICR mice. After administrating with the herbal tea, the fasting blood glucose level of the ICR mice tended to improve. In addition, a significant improvement was seen in the results of postprandial blood sugar and oral glucose tolerance test effectiveness. Therefore, based on the results of this experiment, it is speculated that drinking the herbal tea for 3 months has considerable potential for blood glucose regulation, which can be used as the basis for the development of related products of the herbal tea in the future.

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Effects of Platostoma palustre ethanolic extracts and commercial herbal tea on the cell viability of colorectal cancer cells

Cited by 2 publications

References 11 publications

Functionality and Health-Promoting Properties of Polysaccharide and Plant-Derived Substances from Mesona chinensis

Functionality and Health-Promoting Properties of Polysaccharide and Plant-Derived Substances from Mesona chinensis

Effects of herbal tea (Platostoma palustre) on blood glucose regulation in vivo

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