Effects of platelet release products on neutrophilic phagocytosis and complement receptors

Airway Inflammation and Upregulation of β2 Mac‐1 Integrin Expression on Circulating Leukocytes of Female Ragpickers in India

“…The importance of this integrin in host defense can be judged from the report that showed facilitation of bacterial growth following blockade of leukocyte CD11b/CD18 17) . Neutrophils are among the first cells to respond to inflammation, and circulating platelets help them in this endeavor, first by self-activation, then by mediating integrin expression on the neutrophil surface through release of P-selectin from alpha granules and adenosine tri-and diphosphate from dense bodies 18) . Besides antibacterial activity, Mac-1 integrin molecules mediate antigen presentation and/or T-cell activation 19) .…”

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

“…ATP also promotes adhesion of neutrophils to endothelial cells by upregulating the b2-integrin macrophage antigen (Mac)-1 (CD11b/CD18) (11). Against invading microbes, ATP promotes phagocytosis of pathogens by upregulating Mac-1 (103,175) and promotes the degranulation of granules (99, 100) and increases generation of ROS (61,105,107). In addition, neutrophils release ATP during their inflammatory activation and may enhance those immune responses in an autocrine or paracrine manner.…”

The apolipoprotein CIII-derived peptide, HATKTAK, and stimulation of macromolecular activators of phagocytosis from platelets (MAPPs)

“…Deuel et al 1981); phagocytosis by neutrophils and monocytes is enhanced ; enzyme release and O 2 -generation by neutrophils are induced (Laghi et al 1985, Wu et al 2009); lysosomal degranulation is enhanced (Del Mascio et al 1985); the aggregation and cytotoxicity of neutrophils are induced (Boogaerts et al 1986); the adhesion of neutrophils to endothelial cells and nylon fibers is induced (Oryu et al 1996); the expression of some opsonin receptors is up-regulated (Sakamoto et al 1998, Miyabe et al 2004); the apoptosis of neutrophils is inhibited (Andonegui et MAPPs are platelet-derived activators of the phagocytosis of neutrophils that act via Fcγ receptors (Sakamoto & Ooshima 1986). Studies on the characterization of MAPPs and the mechanisms of MAPP activation by the apolipoprotein CIII (Apo CIII)-derived peptide, HATKTAK (Sakamoto et al 2012) will be reviewed herein, and the perspectives of these studies through immunohistochemistry using an antibody against HATKTAK will be described.…”