Agricultural sustainability ensues when cultivation of field crops and associated techniques improve not just crop yields but also management-responsive soil properties. Bambara groundnut as an underutilized crop lacks research-based information on its agronomic requirements. This paper reports the key fertility indices of a loamy-sand soil in southeastern Nigeria as influenced by soil and agronomic management practices involving factorial combinations of two bambara groundnut varieties (Caro and Olokoro), two plant spacings (30 cm × 75 cm and 45 cm × 75 cm) and four organic/inorganic fertilizer options. These fertilizer options were NPK 15-15-15 (NPK), single super phosphate (SSP), poultry manure (PM) and Control. The plots under Caro variety spaced 30 cm × 75 cm and grown with NPK or SSP fertilizer showed the highest CEC (8.40 cmol kg–1) and exchangeable K (0.15 cmol kg–1), respectively. Olokoro variety spaced 45 cm × 75 cm and grown with PM or SSP gave the highest total nitrogen (0.14%), soil pHwater (6.35), available phosphorus (107.60 mg kg-1) and exchangeable Ca (3.70 cmol kg-1). The interactions plant spacing × fertilizer type and crop variety × fertilizer type affected all the soil fertility indices studied, while crop variety × plant spacing affected soil pHwater, available phosphorus, CEC and exchangeable Ca and Mg. Generally, as main factors, Olokoro variety, NPK and 45 cm × 75 cm improved soil properties better than their counterparts.