Effects of plant-derived isoquinoline alkaloids on growth performance and intestinal function of broiler chickens under heat stress

Kikusato, Motoi; Xue, G D; Pastor, Anja; Niewold, Theo; Toyomizu, Masaaki

doi:10.1016/j.psj.2020.11.050

Cited by 39 publications

(27 citation statements)

References 51 publications

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“…It is currently believed that nutritional regulation is an effective strategy to protect the broilers against HS-induced intestinal injury [ 12 , 13 ]. In this regard, a variety of natural phytochemicals were used as gut health promoters in broilers, and they showed potential stress-alleviating effects because of the multiple biological activities [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplementation of Algae-Derived Polysaccharides on Morphology, Tight Junctions, Antioxidant Capacity and Immune Response of Duodenum in Broilers under Heat Stress

Li¹,

Zhu²,

Zhao³

et al. 2021

Animals

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To evaluate the ameliorative effect of algae-derived polysaccharide (ADP) supplementation on duodenal injury caused by heat stress (HS) in broilers, a total of 144 male yellow-feathered broilers (56-day-old) were randomly allocated into three groups: The TN group (thermoneutral zone, broilers were raised at 23.6 ± 1.8 °C); HS group (heat stress, broilers were exposed to 33.2 ± 1.5 °C 10 h/day, 8:00 a.m.–18:00 p.m., the temperature in the remaining period was consistent with the TN group); HSA group (heat-stressed broilers were fed with ADP supplemented diet at 1000 mg/kg). There were six replications in each treatment, and eight broilers in each replication. The feeding trial lasted four weeks. The results showed that dietary ADP supplementation tended to increase the villus height (p = 0.077) and villus width (p = 0.062), and decrease the apoptosis rate (p = 0.081) in the duodenum of broilers under HS. Furthermore, dietary ADP increased the relative mRNA and protein (based on immunofluorescence) expression levels of occludin and zonula occludens-1 (ZO-1) in the duodenum of broilers under HS (p < 0.05). In addition, dietary ADP enhanced the total antioxidation capacity (T-AOC) and activity of glutathione-S transferase (GST), while reducing the malondialdehyde (MDA) concentration of the duodenum in broilers under HS (p < 0.05). Moreover, dietary ADP supplementation upregulated the duodenal nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), glutathione peroxidase 1 (GPx1) and glutathione S-transferase theta 1 (GSTT1) mRNA expression levels in heat-stressed broilers (p < 0.05). Furthermore, compared with the HS group, broilers fed with an ADP supplemented diet had a higher relative mRNA expression of inhibitor kappa B alpha (IκBα) (p < 0.05) and a lower relative mRNA expression of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the duodenum (p < 0.05). In summary, dietary ADP supplementation had an ameliorative effect on HS-induced impairment of tight junctions, antioxidant capacity and the immune response of the duodenum in broilers. These beneficial effects might be related to the modulation of Nrf2 and NF-κB signaling pathways.

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Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplementation of Algae-Derived Polysaccharides on Morphology, Tight Junctions, Antioxidant Capacity and Immune Response of Duodenum in Broilers under Heat Stress

Li¹,

Zhu²,

Zhao³

et al. 2021

Animals

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“…Other research also indicated that a diet supplemented with Macleaya cordata extract fed to weaned piglets significantly increased villus height, and the ratio of villus height to crypt depth in the duodenum, jejunum and ileum, and decreased the crypt depth in the jejunum [ 51 ]. Furthermore, IQ supplementation inhibited the expression of IL-6 in the ileal tissue of broiler chickens [ 10 ]. It should be taken into account that the number of sows and piglets included in this study is rather low, and the response to IQ supplementation might have been affected by the high sanitary conditions of the experimental farm.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that IQ has antimicrobial [ 1 , 4 ], anti-inflammatory [ 5 , 6 ], antioxidant [ 7 ] and immunomodulatory effects [ 8 ]. In livestock, supplementation with IQ has been shown to increase growth performance in chickens, due to its anti-inflammatory effects [ 9 , 10 ]. In weaning pigs, dietary supplementation with IQ improved growth performance, nutrient digestibility and health status, including anti-inflammatory and antimicrobial beneficial effects [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Isoquinoline Alkaloids in Sows’ Diet Reduce Body Weight Loss during Lactation and Increase IgG in Colostrum

Sureda

Zhao

Artuso-Ponte

et al. 2021

Animals

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Isoquinoline alkaloids (IQ) exert beneficial antimicrobial and anti-inflammatory effects in livestock. Therefore, we hypothesized that supplementing sows’ diets with IQ during gestation would decrease farrowing stress, affecting the piglets’ development and performance. Sows were divided into: IQ1, supplemented with IQ from gestation day 80 (G80) to weaning; IQ2, supplemented from gestation day 110 (G110) to weaning, and a non-supplemented (NC) group. Sow body weight (BW), feed intake, back-fat thickness and back-muscle thickness were monitored. Cortisol, glucose and insulin were measured in sows’ blood collected 5 d before, during, and after 7 d farrowing. Protein, fat, IgA and IgG were analyzed in the colostrum and milk. Piglets were monitored for weight and diarrhea score, and for ileum histology and gene expression 5 d post-weaning. IQ-supplemented sows lost less BW during lactation. Glucose and insulin levels were lower in the IQ groups compared to NC-sows 5 d before farrowing and had higher levels of protein and IgG in their colostrum. No other differences were observed in sows, nor in the measured parameters in piglets. In conclusion, IQ supplementation affected sows’ metabolism, reducing body weight loss during lactation. Providing IQ to sows from their entrance into the maternity barn might be sufficient to induce these effects. IQ improved colostrum quality, increasing the protein and IgG content, improving passive immunity for piglets.

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“…Moreover, LST is excessively rich in alkaloids, avonoids, terpenoids, phenolic compounds, steroids, phytosterols, saponins, coumarins, tannins, glycosides and anthraquinone [30]. Kikusato et al [31] found that plant-derived isoquinoline alkaloids supplementation signi cantly improved the growth performance of chickens under heat stress conditions. Starčević et al [32] reported that phenolic compounds boosted the growth performance and antioxidant pro le of chickens.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary Lasia spinosa Thw. powder supplementation on growth performance, blood metabolites, antioxidant status, intestinal morphology, and cecal microbiome in Chinese yellow-feathered broilers

Yan

Zhang

Tian

et al. 2021

Preprint

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Background: Lasia spinosa Thw. (LST) has been proven to be nutritious and have growth-promoting, antioxidant functions and so on, but its effect in chicken is still unclear. This study aimed to evaluate the effects of dietary LST powder supplementation on growth performance, blood metabolites, antioxidant status, intestinal morphology and cecal microbiome in Chinese yellow-feathered broilers.Methods: A total of 400 one-day-old yellow-feather broilers were randomly allotted to 4 dietary treatments: LST0 group (a basal diet), LST1 group (a basal diet with 1% LST powder), LST2 group (a basal diet with 2% LST powder), LST4 group (a basal diet with 4% LST powder), ten replicates for each treatment and 10 broilers in each treatment group. Results: Results indicated that the average daily feed intake of broilers during 22-42d and the average daily gain of chickens over all periods were significantly increased by dietary supplementation of LST powder compared to a control group, while the feed conversion ratio during the overall periods was markedly decreased. The levels of SOD, CAT and GSH-Px in serum, liver and breast muscle were also significantly increased in LST supplemented groups, while ROS and MDA in serum, liver and breast muscle were decreased. Furthermore, the levels of TG and LDL-C were significantly decreased by the addition of dietary LST powder, while levels of HDL-C, Ca, Fe, Mg and P were linearly increased. Regarding the gut morphometric, crypt depth was significantly decreased by LST supplementation, while villus height and the ratio of villus height to crypt depth were notably increased. Sequencing of 16S rRNA from the cecal contents of broilers revealed that the composition of the chicken gut microbiota was altered by LST supplementation. Moreover, the diversity of microbiota in broilers was increased in the LST1 groups but was decreased in the LST2 and LST4 groups compared with LST0 groups. The differential genera enriched in LST1 groups, such as Bacillus, Odoribacter, Sutterella, Anaerofilum, Peptococcus, were closely related to the increased growth performance, antioxidant status, intestinal morphology, Ca, Mg and reduced blood lipid in the treated broilers. Conclusions: The supplementation of LST powder to the diets of Chinese yellow-feathered broilers improved growth performance, lipid profile, antioxidant indices, intestinal morphology and gut microbiota balance, with its optimum level in yellow-feathered broilers’ diet being 1%.

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Effects of plant-derived isoquinoline alkaloids on growth performance and intestinal function of broiler chickens under heat stress

Cited by 39 publications

References 51 publications

Effects of Dietary Supplementation of Algae-Derived Polysaccharides on Morphology, Tight Junctions, Antioxidant Capacity and Immune Response of Duodenum in Broilers under Heat Stress

Effects of Dietary Supplementation of Algae-Derived Polysaccharides on Morphology, Tight Junctions, Antioxidant Capacity and Immune Response of Duodenum in Broilers under Heat Stress

Isoquinoline Alkaloids in Sows’ Diet Reduce Body Weight Loss during Lactation and Increase IgG in Colostrum

Effects of dietary Lasia spinosa Thw. powder supplementation on growth performance, blood metabolites, antioxidant status, intestinal morphology, and cecal microbiome in Chinese yellow-feathered broilers

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