Effects of Pitavastatin on Fasting and Postprandial Endothelial Function and Blood Rheology in Patients With Stable Coronary Artery Disease

Abstract

Pitavastatin significantly improved fasting and postprandial dyslipidemia and endothelial dysfunction in CAD patients, partly via reducing oxidative stress and increasing plasma adiponectin, although rheological parameters remained unchanged.

Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer

“…Pitavastatin treatment in long-term smokers was associated to reduced LDL-C oxidation and protection of endothelium from oxidative stress (Yoshida et al, 2010). In patients with stable CAD, pitavastatin ameliorated postprandial endothelium-dependent vasodilation, inhibiting oxidative stress (Arao et al, 2009). Moreover, pravastatin and fluvastatin had a direct scavenging radical activity Kassan et al, 2010).…”

Postprandial dysmetabolism: Too early or too late?

“…156 In addition, it has been shown that pitavastatin 2mg/ day may result in reduction of both postprandial hypertriglyceridemia and endothelial dysfunction in obese subjects and in patients with stable coronary artery heart disease. 157,158 Simvastatin 80mg has also been seen to be effective in reducing postprandial plasma triglyceride levels and triglyceride-content in lipoprotein fractions in male obese patients with metabolic syndrome. 159 …”

Single Administration of α-Glucosidase Inhibitors on Endothelial Function and Incretin Secretion in Diabetic Patients With Coronary Artery Disease

“…25, 26 In brief, examinations were performed in a quiet, dark, temperature-controlled (22-24°C) room. Subjects rested for at least 15 min before the examination.…”