Effects of piretanide, bumetanide and frusemide on electrolyte and urate excretion in normal subjects.

Roberts, CJ; Homeida, M.; Roberts, Fred F.; Bogie, W.

doi:10.1111/j.1365-2125.1978.tb00837.x

Cited by 55 publications

(41 citation statements)

References 14 publications

(11 reference statements)

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“…Recent previous studies in rat and in man showed piretanide to be more potent than frusemide (Merkel et al 1976;Roberts, Homeida, Roberts & Bogie, 1978). Given orally in man, 6 mg piretanide were found to be equivalent to 40 mg frusemide and less efficacious than 1 mg bumetanide (Roberts et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

Activity of a new high efficiency diuretic in man: piretanide (HOE 118).

Pozet¹,

Hadj‐Aïssa²,

Pellet³

et al. 1980

Brit J Clinical Pharma

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1 The pharmacological actions of piretanide, a new high efficiency diuretic, were studied in sixteen patients with GFR (inulin clearance) varying from 0.1 -2.5 ml/s. 2 After hydration and following two control periods, a single dose of 6 mg piretanide was ingested. Thereafter, urine was collected every 30 min for 2 h and every hour for the next 4 h. Fluid losses were replaced. 3 The following measurements were made: urine flow rate, clearances of inulin, PAH, urea, creatinine, uric acid, osmolar and free water clearances, excretion rates of sodium, chloride, potassium, calcium, phosphate, bicarbonate, ammonium, titratable acidity and urine pH. 4 Main results showed piretanide was efficient in the group with normal GFR (inulin clearance > 1.5 ml/s) and in the group with slightly decreased GFR (1.0 < inulin clearance < 1.4 ml/s), in terms of diuresis, natriuresis, kaliuresis and calciuresis. It was inefficient in the group with severe renal insufficiency (inulin clearance < 0.3 ml/s). 5Free water clearance showed preservation of diluting ability to a large extent. 6 In the three groups, no significant change in inulin clearance and PAH clearance occurred.

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Section: Discussionmentioning

confidence: 99%

Activity of a new high efficiency diuretic in man: piretanide (HOE 118).

Pozet¹,

Hadj‐Aïssa²,

Pellet³

et al. 1980

Brit J Clinical Pharma

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“…Lysin acetylsalicylate, when given before the diuretics, significantly decreased the diuresis and sodium excretion, and appeared to increase potassium excretion, when given before frusemide but not before piretanide. Lawrence et al (1978) and Roberts et al (1978) have shown, in healthy volunteers, that piretanide has a diuretic effect similar to that of frusemide; one of our previous studies (Valette et al, 1979) de-monstrated that frusemide and piretanide significantly increase venous compliance. Lysin acetylsalicylate inhibits diuresis and the effect on venous compliance when given before both diuretics.…”

Section: Interaction Between Salicylate and Two Loop Diureticsmentioning

confidence: 99%

“…Many studies have shown a direct effect of frusemide on renal prostaglandin metabolism (Bailie, Crosslan & Hook, 1976;Williamson, Bourland & Marchand, 1975). Piretanide, a new high ceiling diuretic, seems to have a similar action to that of frusemide (Merkel, Bormann, Mania, Muschaweck & Hropot, 1976;Lawrence, Ansari & Elliot, 1978;Roberts, Homeida, Roberts & Bogie, 1978;Valette, Duhaze & Apoil, 1979). This study was undertaken to investigate a possible interaction between diuretics and lysin acetylsalicylate, with particular reference to water and sodium excretion, and venous compliance.…”

Section: Interaction Between Salicylate and Two Loop Diureticsmentioning

confidence: 99%

Interaction between salicylate and two loop diuretics.

Valette¹,

Apoil²

1979

Brit J Clinical Pharma

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“…An increase in uric acid excretion immediately following diuretic administration and subsequent retention of uric acid favoured the latter, and suggested that homeostatic sodium-conserving mechanisms might be responsible (Roberts, Homeida, Roberts & Bogie, 1978) Such mechanisms are known to affect the relationship between plasma frusemide level and sodium excretion rate as diuresis proceeds (Branch, Roberts, Homeida & Levine, 1977).…”

mentioning

confidence: 99%