Effects of Piperine in Experimental Intestinal Ischemia Reperfusion Model on Rats

Abstract

BACKGROUND: Piperine is a spice principle, and its protective role against oxidative damage and lipid peroxidation has been reported. In this study, we aimed to investigate the effects of piperine in the prevention of ischemia-reperfusion injury to the small intestine.

Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR‐383/RP105/AKT signalling pathway

“…Moreover, PIP pre‐treatment was reported to reduce oxidative stress, inflammation and apoptosis in DOX‐induced cardiotoxicity 13 . Interestingly, the latest study has indicated that PIP exerts pivotal effects on the pathological process of I/R as well 20,21 . For instance, in a rat model of cerebral I/R injury, Zou et al 32 uncovered that PIP pre‐treatment protected neurocytes from I/R damages by regulating complement and coagulation cascades.…”

“…13 Interestingly, the latest study has indicated that PIP exerts pivotal effects on the pathological process of I/R as well. 20,21 For instance, in a rat model of cerebral I/R injury, Zou et al 32 Timely and effectively reperfusion acts as most efficacious remedy for AMI. 4,6 However, accompanying MIRI largely offset this beneficial effect.…”

“…Previous studies have reported that PIP exerts pharmacological effects possible via miRNA‐dependent manners 16,17 . Recently, the effects of PIP on the modulation of pyroptosis and I/R insults have attracted much attention 18‐21 . However, the exacted effects of PIP via the miRNA‐related ways in MIRI are not clear, and possible pathogenetic mechanism associated with pyroptosis remains unknown.…”

Effect of GBOT on blood lipid and blood glucose metabolism in rats with atherosclerosis

“…Slow progress has been made in understanding the causes and pathogenesis of atherosclerosis. This is largely because of the complex causes of atherosclerosis, slow progression of the disease, and lack of symptoms in the early stage (Akyildiz et al, 2013). Thus, somatic data obtained in most previous studies are mostly cross-sectional, and it is difficult to determine their causal relationship; atherosclerosis lesions in many animal models develop quickly.…”

Effects of bradykinin preconditioning in an experimental intestinal ischemia reperfusion model on rats

“…Pharmacological preconditioning (PPC), known to have protective effects against IR damage, similar to IPC, has been studied with many agents thought to be effective in the intestinal tract by different mechanisms [7][8][9] .…”