Effects of Pioglitazone on Survival and Omental Adipocyte Function in Mice with Sepsis Induced by Cecal Ligation and Puncture

Tsujimura, Yukihiro; Matsutani, Takeshi; Matsuda, Akihisa; Kutsukake, Masahiko; Uchida, Eiji; Sumii, Koji; Tamura, Kazuhiro

doi:10.1016/j.jss.2011.08.012

Cited by 20 publications

(23 citation statements)

References 34 publications

(39 reference statements)

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“…4). As shown in the previous study, 10) CLP treatment up-regulated IL-6 and MCP-1 expression, whereas pioglitazone pretreatment prevented the elevation of these cytokines. Taken together with the results in Figs.…”

Section: Effects Of Clp and Pioglitazone On The Expression Of Il-6 Ansupporting

confidence: 75%

“…10,18) Low preoperative circulating levels of adiponectin might be a risk factor for postoperative infection in patients who undergo colorectal cancer surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Pioglitazone, a peroxisome proliferator-activated receptor (PPAR) γ activator, improved the survival rate in association with increased serum adiponectin levels in cecal ligation and puncture (CLP)-treated mice. [10][11][12] This compound might ameliorate CLP-induced sepsis in part by reducing excessive levels of inflammatory cytokines in adipose tissues.…”

mentioning

confidence: 99%

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Impact of Pioglitazone on Macrophage Dynamics in Adipose Tissues of Cecal Ligation and Puncture-Treated Mice

Matsutani

Tamura

Kutsukake

et al. 2017

Biological & Pharmaceutical Bulletin

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Pioglitazone improves sepsis-induced organ injury accompanied with anti-inflammatory effects on visceral adipose tissue. However, its action in adipose immune cells remains to be ascertained. We investigated the effects of pioglitazone on visceral adipose macrophage population and polarisation in cecal ligation and puncture (CLP)-induced sepsis mice. Eight-week-old male mice were assigned to 3 groups: 1) sham-operated group, 2) CLP group, or 3) pioglitazone-treated CLP group. Pioglitazone (10 mg/kg) was injected intraperitonally for 7 d and CLP surgery was performed. Visceral adipose tissues were collected 24 h after the surgery. mRNA expression of several macrophage markers (inducible nitric oxide synthase (iNOS) for M1, arginase1

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Section: Effects Of Clp and Pioglitazone On The Expression Of Il-6 Ansupporting

confidence: 75%

“…10,18) Low preoperative circulating levels of adiponectin might be a risk factor for postoperative infection in patients who undergo colorectal cancer surgery.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Pioglitazone on Macrophage Dynamics in Adipose Tissues of Cecal Ligation and Puncture-Treated Mice

Matsutani

Tamura

Kutsukake

et al. 2017

Biological & Pharmaceutical Bulletin

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“…IL-6, MCP-1, and TNF α are elevated in mouse wound healing models [40, 41] but not in this breast cancer model, except for IL-1 β , elevated in both models. Similar changes in cytokines were reproduced in separate experiments in this study demonstrating that TT-induced changes in immune function were related to breast cancer and not to wound healing.…”

Section: Discussionmentioning

confidence: 93%

Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size

Gronowicz

Secor

Flynn

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Evidence-based integrative medicine therapies have been introduced to promote wellness and offset side-effects from cancer treatment. Energy medicine is an integrative medicine technique using the human biofield to promote well-being. The biofield therapy chosen for study was Therapeutic Touch (TT). Breast cancer tumors were initiated in mice by injection of metastatic 66cl4 mammary carcinoma cells. The control group received only vehicle. TT or mock treatments were performed twice a week for 10 minutes. Two experienced TT practitioners alternated treatments. At 26 days, metastasis to popliteal lymph nodes was determined by clonogenic assay. Changes in immune function were measured by analysis of serum cytokines and by fluorescent activated cells sorting (FACS) of immune cells from the spleen and lymph nodes. No significant differences were found in body weight gain or tumor size. Metastasis was significantly reduced in the TT-treated mice compared to mock-treated mice. Cancer significantly elevated eleven cytokines. TT significantly reduced IL-1-a, MIG, IL-1b, and MIP-2 to control/vehicle levels. FACS demonstrated that TT significantly reduced specific splenic lymphocyte subsets and macrophages were significantly elevated with cancer. Human biofield therapy had no significant effect on primary tumor but produced significant effects on metastasis and immune responses in a mouse breast cancer model.

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“…Previous studies have shown that pioglitazone treatment increases serum adiponectin level and improves survival after cecal ligation and puncture (CLP) by ameliorating excessive inflammatory host responses in mice [25]; and pioglitazone effectively prevents lung injury caused by CLP-induced sepsis by maintaining the anti-inflammatory status of visceral adipose tissue as well [26]. Yet there has not been any evidence showing that the PPARg agonist could affect the sepsis-induced intestinal injury.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of pioglitazone on sepsis-induced intestinal injury in a rodent model

Gao

Jiang

Xiao

et al. 2015

Journal of Surgical Research

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Effects of Pioglitazone on Survival and Omental Adipocyte Function in Mice with Sepsis Induced by Cecal Ligation and Puncture

Cited by 20 publications

References 34 publications

Impact of Pioglitazone on Macrophage Dynamics in Adipose Tissues of Cecal Ligation and Puncture-Treated Mice

Impact of Pioglitazone on Macrophage Dynamics in Adipose Tissues of Cecal Ligation and Puncture-Treated Mice

Therapeutic Touch Has Significant Effects on Mouse Breast Cancer Metastasis and Immune Responses but Not Primary Tumor Size

Protective effect of pioglitazone on sepsis-induced intestinal injury in a rodent model

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