Effects of Pinus brutia bark extract and Pycnogenol® in a rat model of carrageenan induced inflammation

Ince, İ̇skender; Yeşil-Çeliktaş, Özlem; Karabay-Yavasoglu, N.U.; Elgin, Gozde

doi:10.1016/j.phymed.2009.05.004

Cited by 40 publications

(29 citation statements)

References 21 publications

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“…29 Previous studies have shown that rodents can tolerate extremely high doses of bioflavonoids without any significant detrimental effects. 30 A human clinical study reported that elderly individuals tolerated 150 mg/day of PYC for 3 months without any significant side effects. 31 PYC has very low acute and chronic toxicity with mild unwanted effects occurring in a small percentage of human subjects.…”

Section: Ansari Et Al Discussionmentioning

confidence: 99%

Dose- and Time-Dependent Neuroprotective Effects of Pycnogenol^® following Traumatic Brain Injury

Ansari

Roberts

2013

Journal of Neurotrauma

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After traumatic brain injury (TBI), both primary and secondary injury cascades are initiated, leading to neuronal death and cognitive dysfunction. We have previously shown that the combinational bioflavonoid, PycnogenolÒ (PYC), alters some secondary injury cascades and protects synaptic proteins when administered immediately following trauma. The purpose of the present study was to explore further the beneficial effects of PYC and to test whether it can be used in a more clinically relevant fashion. Young adult male Sprague-Dawley rats were subjected to a unilateral moderate/severe cortical contusion. Subjects received a single intravenous (i.v.) injection of PYC (1, 5, or 10 mg/kg) or vehicle, with treatment initiated at 15 min, 2 h, or 4 h post injury. All rats were killed at 96 h post TBI. Both the cortex and hippocampus ipsilateral and contralateral to the injury were evaluated for possible changes in oxidative stress (thiobarbituric acid reactive species; TBARS) and both pre-and post-synaptic proteins (synapsin-I, synaptophysin, drebrin, post synaptic density protein-95, and synapse associated protein-97). Following TBI, TBARS were significantly increased in both the injured cortex and ipsilateral hippocampus. Regardless of the dose and delay in treatment, PYC treatment significantly lowered TBARS. PYC treatment significantly protected both the cortex and hippocampus from injury-related declines in pre-and postsynaptic proteins. These results demonstrate that a single i.v. treatment of PYC is neuroprotective after TBI with a therapeutic window of at least 4 h post trauma. The natural bioflavonoid PYC may provide a possible therapeutic intervention in neurotrauma.

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Section: Ansari Et Al Discussionmentioning

confidence: 99%

Dose- and Time-Dependent Neuroprotective Effects of Pycnogenol^® following Traumatic Brain Injury

Ansari

Roberts

2013

Journal of Neurotrauma

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“…In the carrageenan induced rat paw edema model the intraperitoneal administration of each of the preparations inhibited paw-swelling dose-dependently exhibiting significant anti-inflammatory activities at doses of 75 and 100 mg/kg. At these doses P. brutia extract also showed a significantly stronger activity than 10 mg/kg of indomethacin (Ince et al, 2009). …”

Section: Resultsmentioning

confidence: 99%

Resins and Gums in Historical Iatrosophia Texts from Cyprus – A Botanical and Medico-pharmacological Approach

Lardos¹,

Prieto²,

Heinrich³

2011

Front. Pharmacol.

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This study explores historical iatrosophia texts from Cyprus from a botanical and medico-pharmacological point of view focusing on remedies containing resins and gums. The iatrosophia are a genre of Greek medical literature of Byzantine origin and can be described as medicine handbooks which serve as therapeutic repositories containing recipes or advice. To extract and analyze information on plant usage in such sources – which are largely unedited texts and so far have not been translated – we investigate (i) the relationship of the iatrosophia to Dioscorides’ De Materia Medica as well as historic pharmaceutical books or standard texts on modern phytotherapy and (ii) the validity of the remedies by comparing them to modern scientific data on reported biological activities. In the six texts investigated 27 substances incorporating plant exudates are mentioned. They are obtained from over 43 taxa of higher plants and in particular are used to treat dermatological, gastrointestinal, and respiratory tract conditions. The comparison to historic pharmaceutical books and phytotherapy texts reflects the gradual decline of the use of plant exudates in Western medicine. While remarkable parallels to Dioscorides’ text exist, the non-Dioscoridean influence suggests a complex pattern of knowledge exchange. Overall, this resulted in an integration of knowledge from so far poorly understood sources. The comparison with bioscientific data reveals a fragmentary picture and highlights the potential of these unexplored substances and their uses. Where relevant bioscientific data are available, we generally found a confirmation. This points to a largely rational use of the associated remedies. Taken together, the iatrosophia are a valuable resource for ethnopharmacological and natural product research. Most importantly they contribute to the understanding of the development of herbal medicines in the (Eastern) Mediterranean and Europe.

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“…(PSZ) has been used as a folk remedy for rheumatism, hemorrhage, gastroenteritis, hypertension and asthma [17]. Recently, a broad spectrum of beneficial effects (antioxidative [18], anti-inflammatory [19,20], antitumor [21]) of PSZ has been reported. However, the anti-NAFLD effects of PSZ have not been identified.…”

Section: Introductionmentioning

confidence: 99%

Pinus densiflora Sieb. et Zucc. Alleviates Lipogenesis and Oxidative Stress during Oleic Acid-Induced Steatosis in HepG2 Cells

Hwang

Kim

et al. 2014

Nutrients

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Excess accumulation of lipids and oxidative stress in the liver contribute to nonalcoholic fatty liver disease (NAFLD). We hypothesized that Pinus densiflora Sieb. et Zucc. (PSZ) can protect against NAFLD by regulating lipid accumulation and oxidative stress in the liver. To investigate the effect of PSZ upon NAFLD, we used an established cellular model: HepG2 cells treated with oleic acid. Then, the extent of hepatic steatosis and oxidative stress was assessed and levels of inflammatory markers measured. Oleic acid-treated HepG2 cells, compared with controls, had greater lipid accumulation. PSZ decreased lipid accumulation by 63% in oleic acid-treated HepG2 cells. Additionally, PSZ decreased the target gene expression of lipogenesis such as sterol regulatory element binding protein-1c, fatty acid synthase, stearoyl-CoA desaturase-1, diacylglycerol O-acyltransferase-1, and acetyl-CoA carboxylase-1 by 1.75, 6.0, 2.32, 1.93 and 1.81 fold, respectively. In addition, Oleic acid-treated HepG2 cells elicited extensive accumulation of tumor necrosis factor-α (TNFα) by 4.53 fold, whereas PSZ-treated cells decreased the expression of TNFα mRNA by 1.76 fold. PSZ significantly inhibited oxidative stress induced by reactive oxygen species. These results suggest that PSZ has effects on steatosis in vitro and further studies are needed in vivo to verify the current observations.

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Effects of Pinus brutia bark extract and Pycnogenol® in a rat model of carrageenan induced inflammation

Cited by 40 publications

References 21 publications

Dose- and Time-Dependent Neuroprotective Effects of Pycnogenol^® following Traumatic Brain Injury

Dose- and Time-Dependent Neuroprotective Effects of Pycnogenol^® following Traumatic Brain Injury

Resins and Gums in Historical Iatrosophia Texts from Cyprus – A Botanical and Medico-pharmacological Approach

Pinus densiflora Sieb. et Zucc. Alleviates Lipogenesis and Oxidative Stress during Oleic Acid-Induced Steatosis in HepG2 Cells

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Effects of Pinus brutia bark extract and Pycnogenol® in a rat model of carrageenan induced inflammation

Cited by 40 publications

References 21 publications

Dose- and Time-Dependent Neuroprotective Effects of Pycnogenol® following Traumatic Brain Injury

Dose- and Time-Dependent Neuroprotective Effects of Pycnogenol® following Traumatic Brain Injury

Resins and Gums in Historical Iatrosophia Texts from Cyprus – A Botanical and Medico-pharmacological Approach

Pinus densiflora Sieb. et Zucc. Alleviates Lipogenesis and Oxidative Stress during Oleic Acid-Induced Steatosis in HepG2 Cells

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Product

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Dose- and Time-Dependent Neuroprotective Effects of Pycnogenol^® following Traumatic Brain Injury

Dose- and Time-Dependent Neuroprotective Effects of Pycnogenol^® following Traumatic Brain Injury