Effects of pimozede on the psychopathology of delusional disorder

Silva, H; Jerez, Sonia; Ramírez, A. Gonzaga; Rentería, Patricia; Aravena, N; Salazar, David Andrés Rincón; Labarca, Rafael

doi:10.1016/s0278-5846(98)00008-6

Cited by 21 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They can also help with the process of monitoring antipsychotic levels, an important strategy that can identify potential reasons for poor response and uncover medication nonadherence, a common problem when treating DD patients [ 103 , 104 , 105 ].…”

Section: Collaboration With Pharmacologistsmentioning

confidence: 99%

Collaboration between Psychiatrists and Other Allied Medical Specialists for the Treatment of Delusional Disorders

et al. 2022

View full text Add to dashboard Cite

Background: There is increasing evidence that individuals with psychosis are at increased risk for cardiovascular disease, diabetes, metabolic syndrome, and several other medical comorbidities. In delusional disorder (DD), this is particularly so because of the relatively late onset age. Aims: The aim of this narrative review is to synthesize the literature on the necessity for medical collaboration between psychiatrists and other specialists. Methods: A non-systematic narrative review was carried out of papers addressing referrals and cooperation among specialists in the care of DD patients. Results: Psychiatrists, the primary care providers for DD patients, depend on neurology to assess cognitive defects and rule out organic sources of delusions. Neurologists rely on psychiatry to help with patient adherence to treatment and the management of psychotropic drug side effects. Psychiatrists require ophthalmology/otolaryngology to treat sensory deficits that often precede delusions; reciprocally, psychiatric consults can help in instances of functional sensory impairment. Close collaboration with dermatologists is essential for treating delusional parasitosis and dysmorphophobia to ensure timely referrals to psychiatry. Conclusions: This review offers many other examples from the literature of the extent of overlap among medical specialties in the evaluation and effective treatment of DD. Optimal patient care requires close collaboration among specialties.

show abstract

Section: Collaboration With Pharmacologistsmentioning

confidence: 99%

Collaboration between Psychiatrists and Other Allied Medical Specialists for the Treatment of Delusional Disorders

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Nevertheless, this was sufficient evidence for pimozide to have an indication for monosymptomatic hypochondriacal psychosis (now delusional disorder somatic type) added to its datasheet and to continue to be used in spite of concerns about cardiotoxicity and sudden unexplained deaths. Three years later, a study reported on a series of seven patients who showed no response to pimozide treatment (Silva 1998 The case for pimozide as a treatment for delusional disorder (and schizophrenia) was subjected to critical evaluation by the Cochrane Collaboration on the basis of all studies identified to July 2005 (Rathbone 2011). Although there were 35 studies relevant for schizophrenia, none were identified for delusional disorder that had sufficient rigour to draw conclusions about efficacy.…”

Section: First-generation (Typical) Antipsychoticsmentioning

confidence: 99%

Recent developments in the management of delusional disorders

Fear¹

2013

Adv. psychiatr. treat

View full text Add to dashboard Cite

SummaryDelusional disorder, rare in clinical practice, remains one of the most enigmatic conditions in psychiatry. Linked to schizophrenia spectrum disorders since the mid-20th century, recent work has confirmed 19th-century notions of an aetiology based on attentional biases and personality dimensions. Unfortunately, the literature exists largely as case reports and series, often published as ‘curiosities’, and therefore lacks the rigour of formal diagnosis. This article reviews current thinking on aetiology and epidemiology, considers diagnosis, and reviews recent work on physical and psychological therapies. It concludes that delusional disorder is likely to respond well to treatment with standard antipsychotics, often at low doses, but that adherence and concordance remain particular problems. Cognitive therapy has been shown to be beneficial but is time-consuming and resource-intensive. Selective serotonin reuptake inhibitors may profit further investigation. There remains considerable scope for investigation of this fascinating condition.

show abstract

“…These authors detailed the numerous adverse side effects associated with pimozide use, particularly extrapyramidal reactions, the risks of tardive dyskinesia, and, notably, cardiac conduction defects. Other authors have not found pimozide to be an effective agent in management of delusional disorder (Silva et al, 1998). A recent Cochrane review (Sultana & McMonagle, 2000) found that the use of pimozide did prolong time to relapse in a range of psychotic disorders, including delusional disorder, although with a relatively wide confidence interval.…”

Section: First-generation Antipsychoticsmentioning

confidence: 99%