Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action

Ferrari, Fernanda Cristina; Lima, Rita de Cássia Lemos; Filha, Z.S. Ferraz; Barros, Camila Helena; Araújo, Marcela Carolina de Paula Michel; Saúde-Guimarães, Dênia Antunes

doi:10.1016/j.jep.2016.01.007

Cited by 29 publications

(19 citation statements)

References 28 publications

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“…Mice were randomly divided into seven groups of five animals each and treated daily for 3 days as follows: 2 control groups (normal and negative control) treated with physiological water (NaCl: 9 ‰); 2 positive control groups treated with indomethacin (3 mg/kg) and colchicine (1 mg/kg); 3 other groups were treated with methanolic extract of rhizomes from S. aethiopicus (75, 150, and 300 mg/kg). After 1 hour, an aliquot (0.15 mL) of MSU (26.6 mg/mL) was injected in the intra-articular region of the left paw for all the groups except the normal control, which received just 0.15 mL of normal saline (23). The diameter of paw was measured at 0, 4, 24, 48, and 72 hours after oedema induction.…”

Section: Induction Of Inflammation Processmentioning

confidence: 99%

Antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus rhizomes

Dadaya

Koubala

Abaissou

et al. 2021

J Herbmed Pharmacol

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Introduction: Siphonochilus aethiopicus is a medicinal plant widely used in the treatment of many inflammatory conditions such as arthritis. The objective of this study was therefore to evaluate the antioxidant and anti-inflammatory properties of methanolic extract of S. aethiopicus rhizomes. Methods: The total phenolic compounds, flavonoid, and tannin content, as well as the in vitro antioxidant activity of the extract, were estimated. The in vivo anti-inflammatory activity was then evaluated in male mice aged 3 to 4 months using the arthritic mouse model induced by carrageenan (0.05 ml; 1%) and monosodium urate (MSU) crystals (26.6 mg/mL). Mice were treated with the methanolic extract of S. aethiopicus (75, 150, 300 mg/kg) and the reference drugs: indomethacin (3 mg/kg) and colchicine (1 mg/kg). The serum, splenic, and hepatic lysosomal enzymes were determined, and oxidative stress biomarkers were estimated. Paws were sectioned for histological analysis. Results: Results showed that S. aethiopicus extract had non-negligible concentrations of polyphenols, flavonoids, and tannins, which could confer it an antioxidant effect. Further, the methanolic extract of S. aethiopicus at different doses significantly (P < 0.05) reduced paw swelling, attenuated joint inflammation, limited the release of lysosomal enzymes, and improved antioxidant enzymes. Conclusion: The methanolic extract of S. aethiopicus has anti-inflammatory and antioxidant properties, and can be used to treat acute forms of gouty arthritis.

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Section: Induction Of Inflammation Processmentioning

confidence: 99%

Antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus rhizomes

Dadaya

Koubala

Abaissou

et al. 2021

J Herbmed Pharmacol

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“…An experimental model of gout as previously mentioned by Lima et al [27] and Ferrari et al [28] with some modifications carried out to investigate the anti-inflammatory effect of α-LA. The assay was performed within a period of 3 days.…”

Section: Anti-inflammatory Effect Of α-La On Gouty Arthritis Inflammamentioning

confidence: 99%

XANTHINE OXIDASE INHIBITORY, ANTIHYPERURICEMIC, ANTI-INFLAMMATORY, ANTINOCICEPTIVE ACTIVITY OF Α-Lipoic ACID IN GOUTY ARTHRITIS MODEL

Hameed

Ramadhan

2018

Asian J Pharm Clin Res

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Objective: The current study was carried out to investigate the xanthine oxidase inhibitory, antihyperuricemic, anti-inflammatory, and antinociception activity of α-lipoic acid (LA) in gouty model of rats.Methods: Enzyme assay was done using bovine milk xanthine oxidase (XO). The XO inhibitory activity in vitro was performed using different doses of α-LA, and the degree of XO inhibition was expressed as IC 50 . The antihyperuricemic activity of α-LA was tested in the potassium oxonate-induced hyperuricemic rats for 7 consecutive days of oral treatment of 10, 25, and 50 mg/kg doses. The anti-inflammatory activity was achieved through monosodium urate crystal-induced inflammation hind paw model in mice. The antinociception effects of α-LA were explored using both of writhings induced by acetic acid test and hot plate test. Results:The study results revealed that the α-LA has a potent activity of XO inhibition with IC 50 = 2.93 µg/mL. Furthermore, these results showed that all doses of α-LA were able to significant reduce of each the following: Serum uric acid levels in the hyperuricemic rats, hind paw thickness of mice at all periods of time assessment, and writhings number in the acetic acid-induced writhing test, while, the same doses significantly increased the reaction latency in mice at hot plate test. Conclusion:The α-LA showed a significant effect on the evaluated models, and therefore it may be a promising agent for the treatment of gout since it possesses XO inhibitory, antihyperuricemic, anti-inflammatory, and antinociception activity.

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Section: Introductionmentioning

confidence: 99%

“…Studies using crude extracts or essential oils obtained from P. pseudocaryophyllus leaves showed a wide potential of pharmacological properties, such as antimicrobial (Lima et al, 2006;Paula et al, 2009;Cust odio et al, 2010;Fernandes et al, 2012;El Assal et al, 2014;Suzuki et al, 2014;Yokomizo and Nakaoka-Sakita, 2014), anxiolytic, antidepressant (Fajemiroye et al, 2012a(Fajemiroye et al, ,b, 2013, antinociceptive, anti-inflammatory , and antioxidant (Campanini et al, 2013(Campanini et al, , 2014. Additionally, Ferrari et al (2016) have recently shown the anti-hyperuricemic Fundac¸ão de Amparo a Pesquisa do Estado de Goi as (FAPEG); contract grant number: 201410267000424. Programa de Bolsa de Incentivo a Pesquisa e Produc¸ão Cient ıfica (PROBIP-UEG); contract grant number: 201410267001444. effects of P. pseudocaryophyllus extracts from leaves and branches in hyperuricemic rats.…”

Section: Introductionmentioning

confidence: 99%

Developmental toxicity evaluation of Pimenta pseudocaryophyllus (Gomes) Landrum, (E)‐methyl isoeugenol chemotype, in Wistar rats

Cardoso

Machado

Paula

et al. 2017

Birth Defects Research

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Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action

Cited by 29 publications

References 28 publications

Antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus rhizomes

Antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus rhizomes

XANTHINE OXIDASE INHIBITORY, ANTIHYPERURICEMIC, ANTI-INFLAMMATORY, ANTINOCICEPTIVE ACTIVITY OF Α-Lipoic ACID IN GOUTY ARTHRITIS MODEL

Developmental toxicity evaluation of Pimenta pseudocaryophyllus (Gomes) Landrum, (E)‐methyl isoeugenol chemotype, in Wistar rats

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