Effects of Pial Incision and Steroid Administration on Experimental Spinal Cord Injury

Optimal time window of myelotomy in rats with acute traumatic spinal cord injury: a preliminary study

“…20,21 A current evidence-based examination of pre-clinical and clinical studies has shown that epidural decompression should be considered from 8 to 24 h following acute traumatic SCI, 4 therefore, we chose 8, 24 and 48 h to evaluate the timing of myelotomy. In this study, our results suggested that myelotomy is still effective in rats up to 48 h after SCI, while previous experimental studies mainly focused on the time points within 24 h. [6][7][8][9] In addition, we found that the potential timing of myelotomy may be between 8 and 24 h after SCI. First, myelotomy at 8 or 24 h after SCI significantly increased BBB scores in rats (Po0.008), while myelotomy at 48 h showed less efficacy (P ¼ 0.023), which indicated that myelotomy between 8-24 h after SCI had a better outcome than at 48 h. Second, the angle value of the inclined plane test or percentage of SWMA in the 8 h-MTG or 24 h-MTG was higher than that in the 48 h-MTG.…”

“…[2][3][4][5][6][7][8][9] Spinal decompression surgery has been widely used in the clinic; however, it cannot remove the constraint from the dura mater and especially the pia mater. Although durotomy or pial incision can release the constraint from the meninges, the hemorrhagic and necrotic tissues cannot be evacuated.…”

“…5,6,8,10,11 Previous studies have shown that myelotomy significantly improves functional recovery when compared with opening of the meninges after SCI. 7,12 However, questions are raised regarding application of myelotomy for SCI, such as suitable operation timing. From the perspective of the reduction of intramedullary pressure, myelotomy should be performed as soon as possible after SCI; from the perspective of the debridement of aseptic necrosis, myelotomy should be performed with a fully liquefied lesion and a clear anatomical delimitation in order to get an adequate drainage, and to minimize the risk of potential surgical damage.…”

Medical Communication Services after Traumatic Spinal Cord Injury

“…Yang et al mentioned that if a durotomy was applied as a control, then conclusion would be more powerful [ 39 ]. In addition, Iwasaki et al presented two groups of dogs by performing myelotomy with or without steroid injection, in which both groups revealed the same outcome and did not show good prognosis [ 40 ]. An experiment study of 40 rats by Rivlin and Tator showed significant improvement only after performing anteroposterior myelotomy, but Dorsal midline myelotomy did not show any improvement [ 41 ].…”