Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration

Schilling, Tatjana; Ebert, Regina; Raaijmakers, Nadja; Schütze, Norbert; Jakob, Franz

doi:10.1016/j.jsbmb.2012.12.006

Cited by 54 publications

(32 citation statements)

References 124 publications

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“…34 ICA has a definite antiosteoporotic effect that is similar to that of estrogen and was able to correct the decreased serum activity of E 2 in OVX rats. 34 ICA has a definite antiosteoporotic effect that is similar to that of estrogen and was able to correct the decreased serum activity of E 2 in OVX rats.…”

Section: Groupsmentioning

confidence: 87%

Icariin prevents ovariectomy-induced bone loss and lowers marrow adipogenesis

Zheng²,

Chang

et al. 2014

Menopause

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Section: Groupsmentioning

confidence: 87%

Icariin prevents ovariectomy-induced bone loss and lowers marrow adipogenesis

Zheng²,

Chang

et al. 2014

Menopause

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“…In summary concerning osteogenesis and adipogenesis, our data do not support a negative influence of heparin on osteogenesis in cultures only containing mesenchyme-derived osteoblast precursors despite the clinical evidence for adverse side effects on bone mineral density upon long-term treatment with heparins (reviewed in [9]). In addition, there is no evidence in vitro supporting a promoted lineage switching from the osteogenic towards the adipogenic fate of hBMSCs that could be one potential reason for osteoporosis development (as reviewed in [56]) among others like possible secondary effects of heparin on in vivo bone formation. Apart from BMP and Wnt signaling, the observed effects might also be a consequence of heparin interactions with fibroblast growth factors (FGF).…”

Section: Discussionmentioning

confidence: 99%

Heparin affects human bone marrow stromal cell fate: Promoting osteogenic and reducing adipogenic differentiation and conversion

Simann

Schneider

Blanc

et al. 2015

Bone

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“…In this regard, phytohormones served as a promising tool by providing dual benefits, (1) modulate the balance between adipogenesis and osteogenesis (2) generates less side-effects, therefore, preventing from fragile fractures. [185] Prevention of bone resorption or inhibition of osteoporotic effect may be due to insulin-like growth factor 1 (IGF-1) mRNA in presence of isoflavones or its similarity with ipriflavone respectively; studies revealed. [186][187][188] A recent study elucidated that soybean oil (15% w/ w) have osteoprotective effect in ovariectomized rats which restored minerals, antioxidant enzymes, antioxidant biomarkers, oxidative stress markers, inflammatory indices, and white blood cells (WBCs) count altered due to the deficiency in the estrogen hormone.…”

Section: Isoflavones and Osteoporosismentioning

confidence: 99%

Soy Bioactive Components in Functional Perspective: A Review

Garg

Lule

Malik

et al. 2016

International Journal of Food Properties

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Functional foods are the focus of attraction for well-being. The healthy living of Asians may be attributed to a diet enriched with soy isoflavones viz. genistein and daidzein which fills the gap of proteinaceous diet in vegetarians. Several factors, such as administration, dosage, metabolism, ingestion of other pharmacological substances, type of estrogen receptors, and presence or absence of endogenous estrogen, affect the activities and bioavailability of isoflavones. The mode of therapeutic action could be either through the stimulation of estrogen receptors or by the non-involvement of estrogen receptors. Soy, due to its isoflavones content, serves as a balanced and remedial substitute in combating various lifestyle disorders, like cancer prevention, by interruption of the breakdown of extracellular matrix that surrounds growing vessels and tumors, lowering of lipid and blood insulin levels by regulating lipid and glucose metabolism, alleviation of menopausal symptoms, and osteoprotective effects by modulating estrogen receptors, thus acting as a safer switch to hormone replacement therapy, anti-hypertensive effect which may also contribute to cardioprotective, anti-oxidative effect, regulation of cognitive functions, and many others. Therefore, it could be regarded as a valuable therapeutics. However, since soy isoflavones also act as endocrine disruptors, they also possess some negative effects. Concerns have been raised in relation to thyroid function abnormality. In view of the previously mentioned facts an attempt has been made to review the literature available on both beneficial as well as deleterious role of isoflavones, soy derived bioactive compounds.

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Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration

Cited by 54 publications

References 124 publications

Icariin prevents ovariectomy-induced bone loss and lowers marrow adipogenesis

Icariin prevents ovariectomy-induced bone loss and lowers marrow adipogenesis

Heparin affects human bone marrow stromal cell fate: Promoting osteogenic and reducing adipogenic differentiation and conversion

Soy Bioactive Components in Functional Perspective: A Review

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