Effects of phytochemicals on thyroid function and their possible role in thyroid disease

Pistollato, Francesca; Masias, Manuel; Agudo-Toyos, Pablo; Giampieri, Francesca; Battino, Maurizio

doi:10.1111/nyas.13980

Cited by 23 publications

(16 citation statements)

References 80 publications

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“…Ferulic acid might act as an anticancer drug by inhibiting autophagy, inducing cell cycle arrest [34], and inducing apoptosis [35]. Phytochemicals had been shown to have either beneficial or detrimental effects on thyroid function [56]. However, the role of the above substances except for hesperidin in thyroid diseases has rarely been reported.…”

Section: Discussionmentioning

confidence: 99%

Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model?

Liu

Chen

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Sargassum species combined with Glycyrrhiza uralensis is a famous herbal pair in traditional Chinese medicine, as one of the so-called “eighteen antagonistic medicaments.” In the Chinese Pharmacopoeia, two different species of Sargassum, Sargassum pallidum and Sargassum fusiforme, are recorded but they are not clearly differentiated in clinical use. In this study, we aimed to determine whether the two species of Sargassum could result in different effects when combined with G. uralensis in Haizao Yuhu Decoction (HYD), which is used for treating thyroid-related diseases, especially goiter. HYD containing S. pallidum or S. fusiforme was administered to rats with propylthiouracil-induced goiter. After 4 weeks, pathological changes in the thyroid tissue and the relative thyroid weight indicated that HYD containing S. pallidum or S. fusiforme protected thyroid tissues from propylthiouracil damage. Neither species increased the propylthiouracil-induced decrease in serum levels of thyroid hormones. However, there were some differences in their actions, and only HYD containing S. fusiforme abated the propylthiouracil-induced elevation of serum thyroid-stimulating hormone levels and activated thyroglobulin mRNA expression.

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Section: Discussionmentioning

confidence: 99%

Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model?

Liu

Chen

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…It is known that some chemicals which alter the genes involved in the HPT axis homeostasis may be associated with an increased incidence of thyroid dysfunction, such as hypothyroidism, hyperthyroidism and cancer (69)(70)(71)(72). Among these, halogenated phenols, tributyltin, polychlorinated biphenyls and surfactants act on the hypothalamus and pituitary, while perchlorate, nitrates, thiocyanates, parabens and pesticides act on the thyroid gland itself (73,74).…”

Section: Glyphosate Toxicity In Hpt Axismentioning

confidence: 99%

Could Glyphosate and Glyphosate-Based Herbicides Be Associated With Increased Thyroid Diseases Worldwide?

Romano

Oliveira

et al. 2021

Front. Endocrinol.

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The increased incidence of thyroid diseases raises a series of questions about what the main predisposing factors are nowadays. If dietary restriction of iodine was once a major global health concern, today, the processes of industrialization of food and high exposure to a wide variety of environmental chemicals may be affecting, directly or indirectly, thyroid function. The homeostasis of hypothalamus–pituitary–thyroid (HPT) axis is finely regulated through the negative feedback mechanism exerted by thyroid hormones. Allostatic mechanisms are triggered to adjust the physiology of HPT axis in chronic conditions. Glyphosate and glyphosate-based herbicides are pesticides with controversial endocrine disrupting activities and only few studies have approached their effects on HPT axis and thyroid function. However, glyphosate has an electrophilic and nucleophilic zwitterion chemical structure that may affect the mechanisms involved in iodide oxidation and organification, as well as the oxidative phosphorylation in the ATP synthesis. Thus, in this review, we aimed to: (1) discuss the critical points in the regulation of HPT axis and thyroid hormones levels balance, which may be susceptible to the toxic action of glyphosate and glyphosate-based herbicides, correlating the molecular mechanisms involved in glyphosate toxicity described in the literature that may, directly or indirectly, be associated to the higher incidence of thyroid diseases; and (2) present the literature regarding glyphosate toxicity in HPT axis.

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“…[35] It should be noted that in vitro studies have demonstrated that quercetin and other flavonoids interfere with thyroid hormone synthesis at multiple steps in the synthetic pathway. [36][37][38][39] The use of quercetin has rarely been associated with hypothyroidism. The clinical impact of this association may be limited to those individuals with pre-existent thyroid disease or those with sub-clinical thyroidism.…”

Section: Prophylaxismentioning

confidence: 99%

Summary of Contact With Dr. Marik. Pulmonary Medicine and Critical Care. Eastern Virginia Medical School - Usa.

Boni¹

2021

JLPPHS

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This brief note introduces the reproduction of medical content, authored by Doctor Paul E. Marik. Dr. Marik is Professor of Medicine and Chief of Pulmonary Medicine and Critical Care at Eastern Virginia Medical School in Norfolk, Virginia (USA). Dr. Marik is an extremely qualified and experienced professional. The reprinting of the material was authorized by Dr. Marik himself on 12/02/2020. This material is relevant in the Brazilian scenario due to standardized procedures for patients infected with the coronavirus. Only 1 of the 5 files kindly provided by the author, in PDF format, was selected and reproduced as received, without any editing. Due to the pandemic's long duration, the Journal editors (who are not medical doctors) have already had the opportunity to monitor the development of the disease in more than one infected person. The type of treatment offered to patients seems to influence the course, duration, and severity of the disease. The treatments described in the materials below appear to be effective and have good results. The editors will refrain from making additional comments on the proposed methods not to influence anyone, restricting themselves to suggesting that they be discussed with the reader's trusted doctor in case of need or doubts. Complete, updated information and also translated into Portuguese are available at . We are grateful to Dr. Marik for his kindness in giving us his time in this troubled period.

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Effects of phytochemicals on thyroid function and their possible role in thyroid disease

Cited by 23 publications

References 80 publications

Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model?

Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model?

Could Glyphosate and Glyphosate-Based Herbicides Be Associated With Increased Thyroid Diseases Worldwide?

Summary of Contact With Dr. Marik. Pulmonary Medicine and Critical Care. Eastern Virginia Medical School - Usa.

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