Effects of Physical Training on Metabolic Control in Elderly Type 2 Diabetes Mellitus Patients

Ligtenberg, P. C.; Hoekstra, J. B. L.; Bol, E.; Zonderland, M. L.; Erkelens, D. W.

doi:10.1042/cs0930127

Cited by 89 publications

(87 citation statements)

References 17 publications

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“…The present study adds significantly to the literature on the health benefits of exercise for type 2 diabetes mellitus patients. Ligtenberg [27] examined the effects of supervised aerobic exercise training in 51 type 2 diabetic patients and found improvements in aerobic capacity and blood lipid variables that favoured the exercise training group compared with a control group; there were no improvements in glycaemic control or insulin sensitivity. In a subsequent analysis [28], they found improvements in anxiety, energy and positive well-being, but not depression (measured by the 22-item version of the WBQ) favouring the aerobic exercise training group.…”

Section: Discussionmentioning

confidence: 99%

Effects of aerobic exercise, resistance exercise or both, on patient-reported health status and well-being in type 2 diabetes mellitus: a randomised trial

et al. 2009

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Aims/hypothesis The Diabetes Aerobic and Resistance Exercise (DARE) study showed that aerobic and resistance exercise training each improved glycaemic control and that a combination of both was superior to either type alone in patients with type 2 diabetes mellitus. Here we report effects on patient-reported health status and well-being in the DARE Trial. Methods We randomised 218 inactive participants with type 2 diabetes mellitus in parallel to 22 weeks of aerobic exercise (n=51), resistance exercise (n=58), combined aerobic and resistance exercise (n=57) or no exercise (control; n=52). Intervention allocation was managed by a central office. Outcomes included health status as assessed by the physical and mental component scores of the Medical Outcomes Trust Short-Form 36-item version (SF-36) and well-being as measured by the Well-Being Questionnaire 12-item version (WBQ-12); these were measured at the Ottawa Hospital. Results Using a p value of 0.0125 for statistical significance due to multiple comparisons, mixed model analyses indicated that resistance exercise led to clinically but not statistically significant improvements in the SF-36 physical component score compared with aerobic exercise (Δ=2.7 points; p=0.048) and control (i.e. no exercise; Δ=3.3 points; p=0.015). For mental component scores, there were clinically important improvements favouring no (control) compared with resistance (Δ=7.6 points; p<0.001) and combined (Δ=7.2 points; p<0.001) exercise. No effects on WBQ-12 scores were noted. Overall, 59/218 (27%) of participants included in this analysis sustained an adverse event during the course of the study, including 16 participants in the combined exercise group, 19 participants in the resistance exercise group, 16 participants in the Electronic supplementary material The online version of this article

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Section: Discussionmentioning

confidence: 99%

Effects of aerobic exercise, resistance exercise or both, on patient-reported health status and well-being in type 2 diabetes mellitus: a randomised trial

et al. 2009

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“…The few intervention studies undertaken in older diabetic adults have reported conflicting results. Ligtenberg et al (1997) found no significant differences in HbA 1c between training and control groups after 12 weeks of physical training, while Raz et al (1994) observed a significant reduction in slightly younger patients following a similar programme of the same duration. In our study, no participants were classified as having high overall physical activity and very few were walking long or frequently enough to favourably influence HbA 1c (Yeater The effect of overall activity on BMI was found to be different for male and female subjects (interaction effect); therefore, ratios of the geometric mean of BMI for medium versus low activity are displayed separately for male and female subjects.…”

Section: Multivariate Model Developed For Hba 1cmentioning

confidence: 92%

Lifestyle factors associated with glycaemic control and body mass index in older adults with diabetes

et al. 2003

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Objective: To investigate the relations between lifestyle factors (diet and exercise), glycated haemoglobin (HbA 1c ) and body mass index (BMI) in older adults with diabetes. Design and setting: A community hospital-based cross-sectional study of 150 noninstitutionalized, ambulatory adults (Z65 y) with diabetes, residing within New Zealand's Kapiti region. Subjects: Patients were recruited from all general practices; two diabetes clinics; local diabetes society and through advertisements in community newspapers. A total of 211 eligible people were identified, but 60 refused to participate and one withdrew. In all, 150 people completed the study (71% participation rate). Methods: Nutrient intakes were calculated by a food-frequency questionnaire. Physical activity was assessed by interview using a validated questionnaire. Medical history and demographic data were obtained by interview or self-completed questionnaires; height, weight and HbA 1c were measured. Multivariate models using bootstrapping and stepwise linear regression were used to select factors associated with HbA 1c and BMI. Results: Each five-unit increase in energy from dietary saturated fat and five-unit increase in BMI were associated with 6% (95% confidence interval ¼ 2-10%; P ¼ 0.004) and 4% (0.3-7%; P ¼ 0.031) increases in HbA 1c , respectively. For females with moderate, compared with low overall activity, there was a 14% (7-20%; P ¼ 0.000) reduction in BMI while for males the reduction was only 5% (À1-11%; P ¼ 0.116). BMI decreased 5% (2-9%; P ¼ 0.004) with each 10-y increase in age, while a fiveunit increment in energy from dietary sucrose was associated with a 6% (1-11%; P ¼ 0.025) increase in BMI. Conclusions: Reducing dietary saturated fat and excess body weight may be useful means of improving glycaemic control in older adults with diabetes. Increasing physical activity and reducing energy from dietary sucrose may assist weight control, the former particularly in women.

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“…Most metabolic studies find a significant effect of exercise on glucose control [22][23][24] and on triglycerides. 25,26 A meta-analysis of clinical trials on the effect of exercise on glucose control found that interventions longer than 8 weeks reduced HbA1c from 8.31% to 7.65% (weighted mean difference 0.66%, PϽ0.001) independently of body mass. This effect is clinically important and is likely to reduce diabetic complications in a significant manner.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity in Relation to Cardiovascular Disease and Total Mortality Among Men With Type 2 Diabetes

et al. 2003

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Background-The present study was conducted to examine the relationship of physical activity with risk of cardiovascular disease (CVD) and mortality among men with type 2 diabetes. CVD risk and mortality are increased in type 2 diabetes. Few epidemiological studies have investigated the effect of physical activity on these outcomes among type 2 diabetics. Methods and Results-Of the 3058 men who reported a diagnosis of diabetes at age 30 years or older in the Health Professionals' Follow-up Study (HPFS), we excluded 255 who reported a physical impairment. In the remaining 2803 men, physical activity was assessed every 2 years; 266 new cases of CVD and 355 deaths of all causes were identified during 14 years of follow-up. Relative risks of CVD and death were estimated from Cox proportional hazards analysis with adjustment for potential confounders. The multivariate relative risks of CVD incidence corresponding to quintiles of total physical activity were 1.0, 0.87, 0.64, 0.72, and 0.67 (P trend ϭ0.07). The corresponding multivariate relative risks for total mortality were 1.0, 0.80, 0.57, 0.58, and 0.58 (P trend ϭ0.005). Walking was associated with reduced risk of total mortality. Relative risks across quintiles of walking were 1.0, 0.97, 0.87, 0.97, and 0.57 (P trend ϭ0.002). Walking pace was inversely associated with CVD, fatal CVD, and total mortality independently of walking hours. Conclusions-Physical activity was associated with reduced risk of CVD, cardiovascular death, and total mortality in men with type 2 diabetes. Walking and walking pace were associated with reduced total mortality. (Circulation. 2003;107: 2435-2439.)

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Effects of Physical Training on Metabolic Control in Elderly Type 2 Diabetes Mellitus Patients

Cited by 89 publications

References 17 publications

Effects of aerobic exercise, resistance exercise or both, on patient-reported health status and well-being in type 2 diabetes mellitus: a randomised trial

Effects of aerobic exercise, resistance exercise or both, on patient-reported health status and well-being in type 2 diabetes mellitus: a randomised trial

Lifestyle factors associated with glycaemic control and body mass index in older adults with diabetes

Physical Activity in Relation to Cardiovascular Disease and Total Mortality Among Men With Type 2 Diabetes

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