Effects of Physical Fatigue in Mice on Learning Performance in a Water Maze

Mizunoya, Wataru; Oyaizu, Shinichi; Hirayama, Akimori; Fushiki, Tohru

doi:10.1271/bbb.68.827

Cited by 17 publications

(13 citation statements)

References 34 publications

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“…As mentioned earlier, the value of the MWM test for mouse models has been discussed controversially in the recent past [5][6][7][8][9]. Nevertheless, it is one of the most commonly used tests to characterize AD mouse models.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a significant number of research groups select the Morris water maze paradigm (MWM) as the method of choice. However, floating behavior, hypothermia, physical fatigue, and thigmotaxis as well as an aversion against swimming of particular inbred strains can be confounders when testing AD models with different genetic backgrounds [5][6][7][8][9]. More comprehensive research into the cognitive deficits of AD mouse models such as the PD-APP transgenic mouse [10] using a variety of tasks for spatial memory (working and reference memory), associated learning, object recognition and operant conditioning has revealed learning and memory impairments beyond spatial memory deficits (for review see [4]).…”

Section: Introductionmentioning

confidence: 99%

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Cognitive phenotyping of amyloid precursor protein transgenic J20 mice

Karl

Bhatia

Cheng

et al. 2012

Behavioural Brain Research

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Transgenic mice that express familial Alzheimer's disease mutant forms of the human amyloid precursor protein (hAPP) have proved to be invaluable in determining the impact that the neurotoxic amyloid-β peptide has in vivo. In addition to the propensity to accumulate cerebral amyloid plaques, a crucial characteristic of hAPP mouse models is their cognitive impairments. To date the most widely used test for analyzing cognitive impairment in hAPP mice is the Morris water maze (MWM) which, due to the fact that mice are not "natural" swimmers, may not always be the ideal paradigm to investigate cognitive behaviours. Furthermore, not all cognitive impairments have been replicated across research laboratories. In the current study, we characterised the cognitive abilities of the J20 transgenic mouse line (expressing the Swedish 670/671 KM->NL and Indiana (717 V->F hAPP mutations) and non-transgenic mice. Mice were assessed in the cheeseboard task (i.e., a 'dry version' of the MWM) and a variety of other cognitive paradigms to test fear conditioning, object recognition and short-term memory to broaden the understanding of the cognitive deficits in J20 mice. hAPP transgenic mice perform normally in tasks for fear conditioning, short-term object recognition and short-term memory of context familiarity. However, they were profoundly impaired in their spatial reference memory capabilities in the cheeseboard task. The cheeseboard task has potential to replace the MWM task in situations where the MWM is not suitable for particular mouse models. AbstractTransgenic mice that express familial Alzheimer"s disease mutant forms of the human amyloid precursor protein (hAPP) have proved to be invaluable in determining the impact that the neurotoxic amyloid-beta peptide has in vivo. In addition to the propensity to accumulate cerebral amyloid plaques, a crucial characteristic of hAPP mouse models is their demonstration of cognitive impairments that can be used as a measure of the impact that modulating numerous physiological pathways may have in the Alzheimer"s disease setting. To date the most widely used test for analyzing cognitive impairment in hAPP mice is the Morris water maze (MWM) which, due to the fact that mice are not "natural" swimmers, may not always be the ideal paradigm as problems associated with floating behavior, hypothermia, physical fatigue and thigmotaxis have been reported in the past. In the current study, we characterized the cognitive abilities of the J20 transgenic mouse line (expressing the Swedish 670/671 KM->NL and Indiana 717 V->F hAPP mutations) and non-transgenic mice using the cheeseboard task (i.e. a "dry version" of the MWM). All mice were also assessed in a variety of other cognitive paradigms to test fear conditioning, short-term object recognition and spatial working memory to broaden the understanding of the cognitive deficits in J20 mice. The transgenic mice performed normally in these latter cognitive paradigms.However, they were profoundly impaired in their spatial reference memory c...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cognitive phenotyping of amyloid precursor protein transgenic J20 mice

Karl

Bhatia

Cheng

et al. 2012

Behavioural Brain Research

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“…All rats experienced 2 days of training that was conducted at 48hrs and on the 5th day after surgery, 60 seconds every time, and 4 times a day. An automatic recording and analytical system (JiLiang Software Technology Company, Shanghai, China) was used to record the time (Escape Latency, EL) and the pathway the rats needed to climb up the platform, to evaluate the ability of learning and spatial memory [13,21,22]. On the 6th day, the platform was removed, and the rats were allowed to swim in the water for 60s.…”

Section: Morris Water Maze Testmentioning

confidence: 99%

“…Reduction of muscle endurance in the model was substantially reflected by decreased struggle time and lower struggle strength. Morris water maze, a classical test to assess physical fatigue, suggested that learning and memory efficiency was impaired in the model of POFS [13]. Furthermore, reactive oxygen species were associated with different types of fatigue [25][26][27][28][29].…”

Section: Nutritional State and Serum Levels Of Sod And Mdamentioning

confidence: 99%

“…An alternative suggestion is that psycho-social stress also participates in the development of POFS [12,13], as previous studies showed that nutritional interventions were ineffective in improving recovery and that negative mood preor postoperatively is strongly related to increased fatigue [9,14]. Behavioural and physiological evidence of POFS include impairment of muscle function, endurance degression, and immobilization.…”

Section: Introductionmentioning

confidence: 99%

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Establishment and assessments of a new model for the postoperative fatigue syndrome by major small intestinal resection in rats

Zhang¹,

Chen²,

Dong³

et al. 2011

Scandinavian Journal of Gastroenterology

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. (2011). Establishment and assessments of a new model for the postoperative fatigue syndrome by major small intestinal resection in rats. Scandinavian Journal of Gastroenterology, 46(11), 1302-1309. DOI: 10.3109/00365521.2011 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Morris water maze test were used to evaluate the degree of POFS. Serum albumin, transferrin, prealbumin and fibronectin were measured to assess the nutritional status, and superoxide dismutase (SOD) and malondealdehyde (MDA) were also measured. Results:As compared to the other 3 groups, the 70% small intestinal resection group showed the worst general state of health, decreased strength of the tail suspension test and the score of Morris water maze test (P<0.05) after operation.All rats suffering small intestinal resection demonstrated a certain degree of malnutrition and behaviour of depression, and the 70% resection group had the lowest levels of transferrin, prealbumin and fibronectin as compared to the other 3 groups (P<0.05), as well as decreased SOD and increased MDA in serum (P<0.05). Conclusions:Resection of 70% of the small intestine resulted in typical characteristics of POFS. As this procedure is simple, stable and easily reproducible, it may serve as a model for research on POFS.

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