Effects of physical exercise and taurine supplementation on cardio‐metabolic risk factors in high caloric‐fed rats

Abstract

To evaluate the effects of exercise sessions, three times a week, and taurine supplementation on blood concentration of glucose, triglycerides and TBARS. Twenty male Wistar rats were divided: sedentary (SD); sedentary taking taurine (SD+TAU); trained (TR) and trained taking taurine (TR+TAU). Exercise training and taurine supplementation (drinking water at 2%) started after four weeks of high caloric diet consumption and was carried out for further five weeks. Animals exercised at a treadmill (20 m/min), 60 min, 3 days/week. Insulin tolerance test (ITT) was done and KITT calculated. After an overnight fasting, rats were sacrificed and glucose, triglycerides, and TBARS concentrations were measured by commercial kits. Data were analyzed by two‐way ANOVA (p<0.05). Exercise protocol improved performance about 45% in booth trained groups. Exercise or taurine, per se, reduced triglycerides (40%,77% and 67% for SD+TAU, TR and TR+TAU, respectively) and augmented KITT (16%,20% and 26% SD+TAU, TR and TR+TAU). TBARS was reduced only in SD+TAU (33%) and TRD+TAU (29%). None differences were seen on body weight and in blood glucose. In conclusion, taurine supplementation, as physical exercise 3 days a week, improves metabolic profile in high caloric fed‐rats, except for oxidative stress biomarker. Financial support: FAPESP