Effects of physical activity participation on cognitive impairment in older adults population with disabilities

Lim, Seung-Taek; Kwak, Hyo-Bum; Kang, Ju-Hee; Chang, Eunwook; Joa, Kyung-Lim; Park, Hee-Jung; Park, Dong-Ho

doi:10.3389/fpubh.2024.1293023

Cited by 1 publication

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References 37 publications

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“…Although prior studies have recognized the positive impact of PA on cognitive well-being ( Jehu et al, 2024 ; Lim et al, 2024 ; Mellow et al, 2024 ; Wang W, et al, 2024 ), the specific association by which PA influences CF and the causal relationships remain insufficiently understood. To address these limitations, our study adopts a pioneering approach by combining comprehensive cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 with Mendelian Randomization (MR) data from the UK Biobank.…”

Section: Introductionmentioning

confidence: 99%

Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study

Liu,

Zhang,

Zhang

2024

Front. Aging Neurosci.

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BackgroundCognitive function (CF) deterioration is a pressing concern in geriatric research. This study aimed to explore the relationship between physical activity (PA) and CF in older adults.MethodsThis study adopted a dual approach, employing both observational and genetic approaches through data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 and Mendelian Randomization (MR) analysis. For the NHANES component, PA levels were evaluated using the Global Physical Activity Questionnaire, and CF was assessed via standardized tests. Multivariate regression, threshold effect analysis, smoothing curve fitting, and subgroup analyses were conducted to examine the association between PA and CF. In parallel, MR methods, using genetic variants as instrumental variables, assessed the causal impact of PA on CF and related conditions such as Alzheimer’s disease and dementia.ResultsObservational findings from NHANES demonstrated a positive correlation between PA and CF, notably among female participants. The detailed analysis identified specific thresholds of PA that correlate with cognitive enhancements. However, MR results did not support a significant causal relationship between PA and CF or dementia-related outcomes, indicating an absence of a direct genetic basis for the observational associations.ConclusionAlthough observational data from NHANES suggest that PA is positively associated with CF in older adults, particularly among women, MR analysis did not confirm these findings as causally related. The discrepancy highlights the complexity of the PA-CF relationship and underscores the need for further research. These results emphasize the potential of PA as a modifiable risk factor for CF, though causal effects remain to be definitively established.

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