Effects of phycoerythrin from Gracilaria lemaneiformis in proliferation and apoptosis of SW480 cells

Li, Peizhen; Jing, Ying; Chang, Qingli; Zhu, Wen; Gao, Yang; Xu, Teng; Yi, Huiguang; Pan, Ruowang; Zhang, Enyong; Zeng, Xiaofeng; Yan, Cheng; Bao, Qiyu; Li, Shengbin

doi:10.3892/or.2016.5162

Cited by 13 publications

(9 citation statements)

References 35 publications

(30 reference statements)

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“…Phycoerythrin (PE) is a bioactive pigment mainly found in Rhodophyta, but it can also be recovered from Cyanobacteria [1]. This water-soluble pigment is a bioactive molecule with interesting properties such as anti-inflammatory, immunosuppressive, antitumor, antioxidant, antidiabetic, and antihypertensive effects [2,3,4,5]. In addition, PE moiety can be exploited as a fluorescent probe useful in cell tracking and imaging assays such as flow cytometry, fluorescent immunoassays, and immunophenotyping.…”

Section: Introductionmentioning

confidence: 99%

Light Intensity and Nitrogen Concentration Impact on the Biomass and Phycoerythrin Production by Porphyridium purpureum

et al. 2019

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Several factors have the potential to influence microalgae growth. In the present study, nitrogen concentration and light intensity were evaluated in order to obtain high biomass production and high phycoerythrin accumulation from Porphyridium purpureum. The range of nitrogen concentrations evaluated in the culture medium was 0.075–0.450 g L−1 and light intensities ranged between 30 and 100 μmol m−2 s−1. Surprisingly, low nitrogen concentration and high light intensity resulted in high biomass yield and phycoerythrin accumulation. Thus, the best biomass productivity (0.386 g L−1 d−1) and biomass yield (5.403 g L−1) were achieved with NaNO3 at 0.075 g L−1 and 100 μmol m−2 s−1. In addition, phycoerythrin production was improved to obtain a concentration of 14.66 mg L−1 (2.71 mg g−1 of phycoerythrin over dry weight). The results of the present study indicate that it is possible to significantly improve biomass and pigment production in Porphyridium purpureum by limiting nitrogen concentration and light intensity.

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Section: Introductionmentioning

confidence: 99%

Light Intensity and Nitrogen Concentration Impact on the Biomass and Phycoerythrin Production by Porphyridium purpureum

et al. 2019

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“…It was previously shown that variations in the chemical structure of a prebiotic can impact its selective fermentation by bacteria [41]. For this reason, there were published large works regarding the investigation of the potential prebiotic effect of single polysaccharides, often contained in seaweeds, but employing pure standards [42][43][44]. However, it should be considered that seaweeds contain other components than also can affect GM.…”

Section: Polysaccharides From Marine Seaweedsmentioning

confidence: 99%

“…Other important peptides are renin inhibitor tridecapeptide [65] and dipeptide [66], which demonstrated hypotensive effect dipeptide. Phycoerythrin [43] and kahalalide F [67] are other important peptidic compounds isolated from seaweeds than showed antitumor effect.…”

Section: Other Bioactive Compounds From Marine Seaweedsmentioning

confidence: 99%

Potential Use of Marine Seaweeds as Prebiotics: A Review

et al. 2020

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Human gut microbiota plays an important role in several metabolic processes and human diseases. Various dietary factors, including complex carbohydrates, such as polysaccharides, provide abundant nutrients and substrates for microbial metabolism in the gut, affecting the members and their functionality. Nowadays, the main sources of complex carbohydrates destined for human consumption are terrestrial plants. However, fresh water is an increasingly scarce commodity and world agricultural productivity is in a persistent decline, thus demanding the exploration of other sources of complex carbohydrates. As an interesting option, marine seaweeds show rapid growth and do not require arable land, fresh water or fertilizers. The present review offers an objective perspective of the current knowledge surrounding the impacts of seaweeds and their derived polysaccharides on the human microbiome and the profound need for more in-depth investigations into this topic. Animal experiments and in vitro colonic-simulating trials investigating the effects of seaweed ingestion on human gut microbiota are discussed.

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“…After extensive in vitro studies which demonstrated the cytotoxic activity of phycoerythrin 15 (Figure 3) [94,107], Pan et al [92] demonstrated its activity in vivo using the S180 tumor-bearing mice model ( Table 2). Results showed that phycoerythrin injection, at a dose of 300 mg/kg b.w., reduced S180 tumor growth by up to 41.3% in treated mice.…”

Section: Phycoerythrinmentioning

confidence: 99%

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

et al. 2019

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Macroalgae are increasingly viewed as a source of secondary metabolites with great potential for the development of new drugs. In this development, in vitro studies are only the first step in a long process, while in vivo studies and clinical trials are the most revealing stages of the true potential and limitations that a given metabolite may have as a new drug. This literature review aims to give a critical overview of the secondary metabolites that reveal the most interesting results in these two steps. Phlorotannins show great pharmaceutical potential in in vivo models and, among the several examples, the anti-dyslipidemia activity of dieckol must be highlighted because it was more effective than lovastatin in an in vivo model. The IRLIIVLMPILMA tridecapeptide that exhibits an in vivo level of activity similar to the hypotensive clinical drug captopril should still be stressed, as well as griffithsin which showed such stunning results over a variety of animal models and which will probably move onto clinical trials soon. Regarding clinical trials, studies with pure algal metabolites are scarce, limited to those carried out with kahalalide F and fucoxanthin. The majority of clinical trials currently aim to ascertain the effect of algae consumption, as extracts or fractions, on obesity and diabetes.Studies focusing on the preparation of macroalgae extracts and their chemical characterization revealed a large range of seaweed compounds with very interesting biological activities including antitumor, anti-inflammatory, antimicrobial, antidiabetic, antivirus, antihypertensive, fat-lowering, and neuroprotective activities [12][13][14][15].The large volume of studies proving the seaweed compound activities in in vitro systems [16][17][18][19] hints the need for further advancements in the knowledge about macroalgae compound efficiency in living systems (in vivo) and their use in the development of pharmaceuticals. In vitro studies are very relevant and yield very important information, but they only represent the first step of a long process, and the results obtained rarely reveal anything about the effects of a compound in vivo, because the responses observed in vitro can be magnified, diminished, or totally different in a more complex and integrated system. In fact, in vivo studies and clinical trials are those which contribute most to truly understanding the real potential of compounds as future pharmaceuticals.In this regard, the present work intends to present insight into the results obtained in the last few years regarding secondary metabolites, such as phlorotannins, halogenated compounds, fucoxanthin, and fucosterol isolated from macroalgae, involved in in vivo studies and clinical trials, identifying the research opportunities and knowledge gaps, to valorize these compounds and their natural resources. The intention is not to present an exhaustive survey of all published works, but rather a selection of authors based on the following criteria: in-depth studies involving pure compounds most characteristic f...

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Effects of phycoerythrin from Gracilaria lemaneiformis in proliferation and apoptosis of SW480 cells

Cited by 13 publications

References 35 publications

Light Intensity and Nitrogen Concentration Impact on the Biomass and Phycoerythrin Production by Porphyridium purpureum

Light Intensity and Nitrogen Concentration Impact on the Biomass and Phycoerythrin Production by Porphyridium purpureum

Potential Use of Marine Seaweeds as Prebiotics: A Review

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

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