Effects of phototherapy using different light sources on oxidant and antioxidant status of neonates with jaundice

Kale, Yusuf; Aydemir, Özge; Çelik, Ülker; Kavurt, Sumru; Işıkoğlu, Semra; Baş, Ahmet Yağmur; Demirel, Nihal

doi:10.1016/j.earlhumdev.2013.09.013

Cited by 33 publications

(22 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In supporting our findings, several studies demonstrated the genotoxic role of phototherapy in jaundiced neonates by using alkaline comet assay, SCE frequency, and micronucleus assay[5-11]. This effect is more likely due to the oxidative role of phototherapy[29,30]. In contrast to our results, Karakukcu et al .…”

Section: Discussionsupporting

confidence: 84%

An Increased Genotoxic Risk in Lymphocytes from Phototherapy-Treated Hyperbilirubinemic Neonates

Mesbah‐Namin

Shahidi

Nakhshab

2017

IBJ

View full text Add to dashboard Cite

Background:Phototherapy is believed to be a safe method for the management of hyperbilirubinemia. However, there are some controversial issues regarding the genotoxic effects of phototherapy on DNA. The aim of this study was to investigate morphologically both phototherapy-induced DNA double-strand breaks (DSBs) and apoptosis in lymphocytes derived from jaundiced and non-jaundiced neonates.Methods:Newborns were divided into three groups, including phototherapy-treated (PT, n=30) jaundiced newborns with total serum bilirubin (TSB) levels >15 mg/dl, non-treated jaundiced newborns (C+, n=27), as positive, as well as healthy negative (C-, n=30) controls with TSB levels ranging from 10 and 15 mg/dl and less than 5 mg/dl, respectively. Lymphocytes were isolated from whole blood samples by Ficoll-isopaque density gradient centrifugation and then assessed for DNA damage and apoptosis before and 24 hours after incubation at 37°C in 5% CO2 using the neutral comet assay.Results:DSB levels were significantly much higher in the PT group compared to the controls before incubation but decreased remarkably after the incubation period. As expected, no statistical differences were found between the two control groups before and after incubations. The frequency of apoptotic cells showed no significant differences among all the three groups before incubation; however, it was significantly increased in the PT group after incubation.Conclusion:It seems that phototherapy in jaundiced infants is able not only to induce apoptosis in newborn lymphocytes but also to affect indirectly DNA integrity.

show abstract

Section: Discussionsupporting

confidence: 84%

An Increased Genotoxic Risk in Lymphocytes from Phototherapy-Treated Hyperbilirubinemic Neonates

Mesbah‐Namin

Shahidi

Nakhshab

2017

IBJ

View full text Add to dashboard Cite

show abstract

“…We observed a reduction of bilirubinemia after 24 hours of 10.4%. Kale [17] in Turkey reported 32.6%, a reduction in the average level of total bilirubin after 24…”

Section: Discussionmentioning

confidence: 98%

Jaundice in the Newborn at the Teaching Hospital of Brazzaville

Bowassa¹,

Ngono²,

Ngakengni³

et al. 2019

OJPed

View full text Add to dashboard Cite

Introduction: Jaundice is a major symptom during neonatal time. It is defined by a bilirubin ≥ 50 mg/l. Objectives: To determine the frequency of neonatal jaundice at the Brazzaville University Hospital, to determine the main etiologies, to evaluate the management, to specify the evolution. Patients and Method: It was a prospective and descriptive study that was conducted in the . It included newborn children admitted into the neonatal unit for treatment of jaundice. The variables studied were epidemiological, clinical, etiological therapy and outcome. Results: The frequency of the neonatal jaundice is 7.2%. The hyperbilirubinemia as not conjugated was found in 99.1% of cases. The main causes are bacterial neonatal infection n = 102 (47.9%), the physiological icterus n = 46 (21.6%) and the ABO incompatibility n = 40 (18.8%). The treatment consists of the phototherapy in all cases. Each phototherapy session lasts 3 hours n = 99 (56.9%), 6 hours n = 58 (33.3%) and 12 hours n = 17 (9.8%). The average duration of the administering of the therapy is of 3 ± 2 days. Hyperbilirubinemia encephalopathy occurred in 62 (29.1%) cases, including 49 cases of kernicterus. The death occurred in 70 (32.9%) children. Conclusion: The importance and the gravity of the neonatal jaundice require primary preventive means based on proper care in pregnancy and the birth. While the secondary prevention includes high index of suspicion, comprehensive diagnostic equipment availability to prevent acute bilirubin encephalopathy.

show abstract

“…Phototherapy is generally considered as a safe and well-tolerated therapy for neonatal jaundice (4). Recently, phototherapy has been proven to be associated with oxidative stress, lipid peroxidation and DNA damage (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Effects of Phototherapy on Antioxidant Status of Preterm and Term Infants with Hyperbilirubinemia

et al. 2016

View full text Add to dashboard Cite

Objectives: The primary purpose of this study was to investigate the effects of phototherapy on antioxidant status of preterm and term infants with hyperbilirubinemia. Methods:Term and preterm infants were divided to three groups; group 1: 28 to < 32 weeks, group 2: 32 to < 37 weeks, and group 3: term infants hospitalized due to jaundice requiring phototherapy during the first to ninth day of life . Fifty-six infants were included in this study. Levels of serum total bilirubin, malondialdehyde, superoxide dismutase, reduced glutathione and catalase were measured before and 24 hours after phototherapy.Results: It was found that the reduced glutathione levels in group 1 including preterm infants decreased significantly after phototherapy. It was observed that levels of malondialdehyde increased significantly in term infants compared to preterm infants in group 1 and group 2. It was observed that the decreases in bilirubin and superoxide dismutase enzyme were correlated in group 2 preterm infants and group 3 term infants.Conclusions: Phototherapy did not significantly affect the antioxidant level in the present study. The fact that there was a significant decrease in glutathione peroxidase levels after phototherapy only in group 1 preterm infants suggests that more attention should be paid when phototherapy is used in this age group.

show abstract

Effects of phototherapy using different light sources on oxidant and antioxidant status of neonates with jaundice

Cited by 33 publications

References 20 publications

An Increased Genotoxic Risk in Lymphocytes from Phototherapy-Treated Hyperbilirubinemic Neonates

An Increased Genotoxic Risk in Lymphocytes from Phototherapy-Treated Hyperbilirubinemic Neonates

Jaundice in the Newborn at the Teaching Hospital of Brazzaville

Effects of Phototherapy on Antioxidant Status of Preterm and Term Infants with Hyperbilirubinemia

Contact Info

Product

Resources

About