Effects of photobiomodulation therapy with red LED on inflammatory cells during the healing of skin burns

Simões, Thamyres Maria Silva; Neto, José de Alencar Fernandes; Nonaka, Cassiano Francisco Weege; Catão, Maria Helena Chaves de Vasconcelos

doi:10.1007/s10103-022-03537-9

Cited by 4 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 34 LED therapy promotes better tissue organization, with larger granulation tissue areas, the presence of hair follicles, and well-developed dermal papillae. 35 Although we did not fully investigate the effect of OLED on hair growth, our preliminary laboratory study on human follicle dermal papilla cells (DPCs) showed significantly increased mRNA expressions of 5a-reductase-1, VEGFa, FGF-7, and FGF-10 after OLED irradiation ( Supplementary Fig. 2 , only online).…”

Section: Discussionmentioning

confidence: 99%

Exploring the Safety and Efficacy of Organic Light-Emitting Diode in Skin Rejuvenation and Wound Healing

Lee,

Ham

et al. 2024

Yonsei Med J

View full text Add to dashboard Cite

Purpose Photobiomodulation (PBM), encompassing low-energy laser treatment and light-emitting diode (LED) phototherapy, has demonstrated positive impacts on skin rejuvenation and wound healing. Organic light-emitting diodes (OLEDs) present a promising advancement as wearable light sources for PBM. However, the biological and biochemical substantiation of their skin rejuvenation and wound healing effects remains limited. This study aimed to ascertain the safety and efficacy of OLEDs as a next-generation PBM modality through comprehensive in vitro and in vivo investigations. Materials and Methods Cell viability assays and human ex vivo skin analyses were performed after exposure to OLED and LED irradiation to examine their safety. Subsequent evaluations examined expression levels and wound healing effects in human dermal fibroblasts (HDFs) using quantitative reverse transcription-polymerase chain reaction, enzyme-linked immunosorbent assay, and wound healing assays post-irradiation. Additionally, an in vivo study was conducted using a ultra violet (UV)-irradiated animal skin model to explore the impact of OLED exposure on dermal collagen density and wrinkles, employing skin replica and tissue staining techniques. Results OLED irradiation had no significant morphological effects on human skin tissue, but caused a considerably higher expression of collagen than the control and LED-treated groups. Moreover, OLED irradiation reduced the expression levels of matrix metalloproteinases (MMPs) more effectively than did LED on HDFs. OLED irradiation group in HDFs had significantly higher expression levels of growth factors compared to the control group, but similar to those in the LED irradiation group. In addition, OLED irradiation on photo-aged animal skin model resulted in increased collagen fiber density in the dermis while reducing ultra violet radiation-mediated skin wrinkles and roughness, as shown in the skin replica. Conclusion This study established comparable effectiveness between OLED and LED irradiation in upregulating collagen and growth factor expression levels while downregulating MMP levels in vitro. In the UV-irradiated animal skin model, OLED exposure post UV radiation correlated with reduced skin wrinkles and augmented dermal collagen density. Accelerated wound recovery and demonstrated safety further underscore OLEDs’ potential as a future PBM modality alongside LEDs, offering promise in the realms of skin rejuvenation and wound healing.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring the Safety and Efficacy of Organic Light-Emitting Diode in Skin Rejuvenation and Wound Healing

Lee,

Ham

et al. 2024

Yonsei Med J

View full text Add to dashboard Cite

show abstract

“…Red, green, and blue emissive iridium compounds are necessary to fabricate white organic light-emitting diodes (OLEDs) for lighting and display purposes. In view of this, a large number of iridium(III) emitters are already well studied and optimized. − Anyway, also the deep-red and near-infrared (NIR) spectral region requires special attention because such saturated red emission is able to penetrate deeply into the body tissue, assisting a speedy wound-healing and regenerating the damaged tissues by means of so-called photo-biomodulation therapies. − To do so, an efficient emitter in combination with simple, flexible, or easy-to-make device architecture is necessary. In this field, light-emitting electrochemical cells (LEECs) become more advantageous than PhOLEDs because they are the simplest form of light-emitting device where a photo-electro emissive ionic material is usually embedded between a reflective aluminum cathode and transparent indium tin oxide (ITO) anode.…”

Section: Introductionmentioning

confidence: 99%

Cationic Iridium(III) Complexes with Benzothiophene-Quinoline Ligands for Deep-Red Light-Emitting Electrochemical Cells

et al. 2022

View full text Add to dashboard Cite

Three new cationic cyclometalated iridium(III) complexes equipped with differently substituted benzo[b]thiophen-2-ylquinoline cyclometalating ligands and with a sterically demanding tert-butylsubstituted 2,2′-bipyridine ancillary ligand were synthesized and structurally characterized by NMR and X-ray diffraction techniques. To tune the electronic properties of such complexes, the quinoline moiety of the cyclometalating ligands was kept pristine or equipped with electronwithdrawing phenyl and −CF 3 substituents, leading to complexes 1, 2, and 3, respectively. A complete electrochemical and photophysical investigation, supported by density functional theory calculations, permits a deep understanding of their electronic properties. The emission of all complexes arises from ligand-centered triplet states in the spectral range between 625 and 950 nm, with excited-state lifetimes between 2.10 and 6.32 μs at 298 K. The unsubstituted complex (1) exhibits the most blue-shifted emission in polymeric matrix at 298 K (λ max = 667 nm, photoluminescence quantum yield (PLQY) = 0.25 and τ = 5.32 μs). The phenyl-substituted complex (2) displays the highest photoluminescent quantum yields (up to 0.30 in polymeric matrix), while the CF 3 -substituted counterpart (3) shows the most redshifted emission, peaking at approx. 720 nm, but with lower quantum yields (e.g., 0.10 in polymeric matrix at 298 K). Complexes 1 and 2 were tested in single-layer nondoped light-emitting electrochemical cells (LEECs), using a nozzle-printing technique; both devices display deep-red electroluminescence with an external quantum efficiency close to 20%.

show abstract

Effects including photobiomodulation of galactomannan gel from Cassia grandis seeds in the healing process of second-degree burns

Souza,

Ribeiro,

Seixas

et al. 2023

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Effects of photobiomodulation therapy with red LED on inflammatory cells during the healing of skin burns

Cited by 4 publications

References 23 publications

Exploring the Safety and Efficacy of Organic Light-Emitting Diode in Skin Rejuvenation and Wound Healing

Exploring the Safety and Efficacy of Organic Light-Emitting Diode in Skin Rejuvenation and Wound Healing

Cationic Iridium(III) Complexes with Benzothiophene-Quinoline Ligands for Deep-Red Light-Emitting Electrochemical Cells

Effects including photobiomodulation of galactomannan gel from Cassia grandis seeds in the healing process of second-degree burns

Contact Info

Product

Resources

About