Effects of photobiomodulation on mitochondrial function in diabetic adipose-derived stem cells in vitro

Fallahi, Faezeh; Mostafavinia, Atarodalsadat; sharifi, Zahranadia; Shalmani, Leila Mohaghegh; Amini, Abdollah; Ahmadi, Houssein; Omidi, Hamidreza; Hajihosseintehrani, Masoumeh; Bayat, Sahar; Hamblin, Michael R.; Chien, Sufan; Bayat, Mohammad

doi:10.1016/j.saa.2022.121835

Cited by 11 publications

(8 citation statements)

References 30 publications

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“…Professor Bayat, from Shahid Beheshti University of Medical Sciences in Iran, was the author with the highest number of published papers. He has conducted a series of studies on the mechanisms and therapeutic effects of photobiomodulation in stem cell therapy for DF[ 46 , 47 ]. His research has shown that subjecting diabetic adipose-derived stem cells to photobiomodulation prior to treatment markedly expedites the process of wound healing[ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

Shi,

Yuan,

et al. 2024

World J Stem Cells

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BACKGROUND Stem cell therapy has shown great potential for treating diabetic foot (DF). AIM To conduct a bibliometric analysis of studies on the use of stem cell therapy for DF over the past two decades, with the aim of depicting the current global research landscape, identifying the most influential research hotspots, and providing insights for future research directions. METHODS We searched the Web of Science Core Collection database for all relevant studies on the use of stem cell therapy in DF. Bibliometric analysis was carried out using CiteSpace, VOSviewer, and R (4.3.1) to identify the most notable studies. RESULTS A search was conducted to identify publications related to the use of stem cells for DF treatment. A total of 542 articles published from 2000 to 2023 were identified. The United States had published the most papers on this subject. In this field, Iran’s Shahid Beheshti University Medical Sciences demonstrated the highest productivity. Furthermore, Dr. Bayat from the same university has been an outstanding researcher in this field. Stem Cell Research & Therapy is the journal with the highest number of publications in this field. The main keywords were “diabetic foot ulcers,” “wound healing,” and “angiogenesis.” CONCLUSION This study systematically illustrated the advances in the use of stem cell therapy to treat DF over the past 23 years. Current research findings suggested that the hotspots in this field include stem cell dressings, exosomes, wound healing, and adipose-derived stem cells. Future research should also focus on the clinical translation of stem cell therapies for DF.

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Section: Discussionmentioning

confidence: 99%

Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

Shi,

Yuan,

et al. 2024

World J Stem Cells

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“…In addition, a significant number of articles mentioned the relationship between oxidative stress and PBM [58–60]. PBM may reduce the oxidative‐reductive status of oral cancer by increasing glycolysis and impact both normal and tumor cells through various pathways [61].…”

Section: Discussionmentioning

confidence: 99%

Effects of low‐level Er:YAG laser irradiation on proliferation and gene expression in primary gingival fibroblasts isolated from mouse maxilla

Lin,

Niimi,

Hirota

et al. 2023

Journal of Biophotonics

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We investigated the effects of low‐level Er:YAG laser irradiation on proliferation and alternations in early gene expression of gingival fibroblasts. Mice primary gingival fibroblasts were irradiated with an Er:YAG laser (1.8, 3.9, and 5.8 J/cm2). Irradiation at 3.9 J/cm2 promoted cell proliferation without significant changes in lactate dehydrogenase or Hspa1a expression. Three hours after irradiation at 3.9 J/cm2, the Fn1 expression level was significantly increased. RNA‐seq identified 15 differentially expressed genes between irradiated and non‐irradiated cells, some of which belonged to immediate early genes (IEGs). Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated MAPK pathway enhancement, and gene set enrichment analysisshowed enrichment in the TGF‐β signaling gene set. Enhanced proliferation via laser irradiation disappeared upon inhibition of Dusp4, Dusp5, and Tgfr1 expression. Low‐level Er:YAG laser irradiation, especially at 3.9 J/cm2 without a major temperature elevation, enhanced fibroblast proliferation, via TGF‐β and the MAPK signaling pathway following IEG expression.This article is protected by copyright. All rights reserved.

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“…By regulating ROS levels, PBM may enhance mitophagy, helping cells to remove dysfunctional mitochondria [ 62 ]. This in turn supports protein activity (involving PINK1/Parkin signaling) [ 63 ], which helps regulate mitophagy [ 64 ].…”

Section: Pathophysiological Aspects Of Tbi and Related Pbm Researchmentioning

confidence: 99%

“…Autophagy and Lysosomal Dysfunction PBM can restore mitochondrial function and improve mitophagy by regulating autophagy and lysosomal activity [61][62][63][64].…”

Section: Axonal Degenerationmentioning

confidence: 99%

Traumatic Brain Injury Recovery with Photobiomodulation: Cellular Mechanisms, Clinical Evidence, and Future Potential

Lim

2024

Cells

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Traumatic Brain Injury (TBI) remains a significant global health challenge, lacking effective pharmacological treatments. This shortcoming is attributed to TBI’s heterogeneous and complex pathophysiology, which includes axonal damage, mitochondrial dysfunction, oxidative stress, and persistent neuroinflammation. The objective of this study is to analyze transcranial photobiomodulation (PBM), which employs specific red to near-infrared light wavelengths to modulate brain functions, as a promising therapy to address TBI’s complex pathophysiology in a single intervention. This study reviews the feasibility of this therapy, firstly by synthesizing PBM’s cellular mechanisms with each identified TBI’s pathophysiological aspect. The outcomes in human clinical studies are then reviewed. The findings support PBM’s potential for treating TBI, notwithstanding variations in parameters such as wavelength, power density, dose, light source positioning, and pulse frequencies. Emerging data indicate that each of these parameters plays a role in the outcomes. Additionally, new research into PBM’s effects on the electrical properties and polymerization dynamics of neuronal microstructures, like microtubules and tubulins, provides insights for future parameter optimization. In summary, transcranial PBM represents a multifaceted therapeutic intervention for TBI with vast potential which may be fulfilled by optimizing the parameters. Future research should investigate optimizing these parameters, which is possible by incorporating artificial intelligence.

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Effects of photobiomodulation on mitochondrial function in diabetic adipose-derived stem cells in vitro

Cited by 11 publications

References 30 publications

Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

Effects of low‐level Er:YAG laser irradiation on proliferation and gene expression in primary gingival fibroblasts isolated from mouse maxilla

Traumatic Brain Injury Recovery with Photobiomodulation: Cellular Mechanisms, Clinical Evidence, and Future Potential

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