Effects of photobiomodulation on interleukin-10 and nitrites in individuals with relapsing-remitting multiple sclerosis – Randomized clinical trial

Silva, Tamiris; Fragoso, Yára Dadalti; Rodrigues, Fernanda; Gomes, Andréa Oliver; Silva, Fernanda Cordeiro da; Andreo, Lucas; Viana, Ariane; Silva, Daniela de Fátima Teixeira da; Chavantes, Maria Cristina; Horliana, Anna Carolina Ratto Tempestini; Angelis, Kátia De; Deana, Alessandro Melo; Branco, Luciana Prats; Fernandes, Kristianne Porta Santos; Motta, Lara Jansiski; Mesquita‐Ferrari, Raquel Agnelli; Bussadori, Sandra Kalil

doi:10.1371/journal.pone.0230551

Cited by 16 publications

(12 citation statements)

References 28 publications

(40 reference statements)

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“…It is made available under a preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted September 14, 2021. ; https://doi.org/10.1101/2021.09.14.460393 doi: bioRxiv preprint 10 a range of neurological conditions, for example macular degeneration, Parkinson's disease, Alzheimer's disease, traumatic brain injury, stroke and multiple sclerosis (41 -48). There are also clinical reports of positive outcomes in aged humans and in patients suffering from many of these conditions (49)(50)(51)(52)(53)(54)(55)(56). Our findings, coupled with the highly conserved nature of the mechanism across species indicated that there are specific but limited times of day when this method is effective, but long periods when it is not; this feature could prove pivotal in achieving the maximum therapeutic outcome in both experimental laboratory and clinical settings.…”

Section: Discussionmentioning

confidence: 56%

The morning burst: Shifting daily patterns of ATP production in Drosophila and temporal windows for their improvement in ageing

Jeffery

Shinhmar

Kam

et al. 2021

Preprint

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Mitochondria produce energy for cell function via adenosine triphosphate (ATP) and are regulated by a molecular 24h clock. Here we use Drosophila melanogaster to reveal shifts in whole animal ATP production over 24h, showing a marked peak in the morning that declines around midday and remains low from then through to the following morning. Mitochondrial membrane potential and ATP production has been shown previously to improve after long wavelength exposure, but apparently not at all times. Hence, to explore this further we exposed flies to 670nm at different times. Exposures between 08.00 and 11.00 resulted in a significant increase in ATP, while exposures at other times had no effect. Within the morning window, not all times were equally effective, however, 670nm exposure mid-morning when ATP production was maximal did not increase ATP, possibly because mitochondria lacked spare capacity at this time. Hence, in the morning there is a complex dynamic relationship between long wavelength light and mitochondria. Mitochondrial function and the influence of long wavelengths are conserved across species from fly to human, and determining the time points for light administration to improve function in ageing and disease is of key importance. Our data progress this search and reveal the outline of these times.

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Section: Discussionmentioning

confidence: 56%

The morning burst: Shifting daily patterns of ATP production in Drosophila and temporal windows for their improvement in ageing

Jeffery

Shinhmar

Kam

et al. 2021

Preprint

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“…The changes in IL-10 values have been studied by other authors. Silva et al note that the reference values for IL-10 in individuals with MS are scarce [ 22 ]. According to Kwilasz et al, the IL-10 levels in peripheral-blood mononuclear cells are lower in individuals with MS compared to healthy controls.…”

Section: Discussionmentioning

confidence: 99%

IL-10 Gene Polymorphisms and IL-10 Serum Levels in Patients with Multiple Sclerosis in Lithuania

et al. 2022

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Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with features of demyelination and axonal degeneration at a young age. Genetic factors may play an important role in the development of multiple sclerosis. (1) Objective: To investigate IL-10 rs1800871, rs1800872, rs1800896, and IL-10 serum levels in patients with multiple sclerosis. (2) Methods: Our study included patients with multiple sclerosis (n = 127) and healthy volunteers (n = 195). The subjects’ DNA was extracted from peripheral blood leukocytes and genotyped by real-time polymerase chain reaction. The results were analyzed using the program “IBM SPSS Statistics 27.0”. (3) Results: The IL-10 SNPs were analyzed between the MS and control groups; however, no statistically significant results were found. The serum levels of IL-10 in the groups of MS and healthy subjects were not statistically significantly different (median (IQR): 0.828 (1.533) vs. 0.756 (0.528), p = 0.872). (4) Conclusion: IL-10 rs1800871, rs1800872, and rs1800896 and serum IL-10 levels are not likely to be associated with MS development. However, individuals carrying the rare haplotypes of rs1800871, rs1800872, and rs1800896 were associated with increased odds of MS (p = 0.006).

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“…61 Interestingly, another randomized clinical trial on 14 MS patients showed that photobiomodulation (wavelength: 808 nm; power output: 100 mW) successfully induced the expression of the serum IL-10 anti-inflammatory cytokine in the MS patient with no statistical difference in nitrites levels. 62 It was also reported that LLLT had a great impact on optic nerve improvement in MS individuals. 63 Mesenchymal stem cells (MSCs) are multipotent stem cells and have great immunomodulatory properties and differentiation abilities.…”

Section: Effect Of the Laser On The Central Nervous Systemmentioning

confidence: 97%

The Role of Low-Level Laser Therapy in the Treatment of Multiple Sclerosis: A Review Study

2021

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Introduction: Multiple sclerosis (MS) is an autoimmune disease. Inflammatory cells, cytokines and chemokines play a major role in the pathogenesis of the disease. Low-level laser therapy (LLLT) as a photobiostimulation approach could affect a wide range of cellular responses. LLLT inhibits the inflammatory signaling pathway, improves cell viability, inhibits apoptosis, modulates immune responses and induces the production of growth factors. Methods: In this review, we discuss the effect of LLLT on cellular responses and its application in the treatment of MS. Such keywords as "low-level laser therapy", "photobiomodulation" and "multiple sclerosis" were used to find studies related to laser therapy in MS in Google scholar, PubMed and Medline databases. Results: LLLT reduced the inflammatory immune cells and mediators. It also enhanced the regeneration of neurons. Conclusion: Investigations showed that besides current treatment strategies, LLLT could be a promising therapeutic approach for the treatment of MS.

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Effects of photobiomodulation on interleukin-10 and nitrites in individuals with relapsing-remitting multiple sclerosis – Randomized clinical trial

Cited by 16 publications

References 28 publications

The morning burst: Shifting daily patterns of ATP production in Drosophila and temporal windows for their improvement in ageing

The morning burst: Shifting daily patterns of ATP production in Drosophila and temporal windows for their improvement in ageing

IL-10 Gene Polymorphisms and IL-10 Serum Levels in Patients with Multiple Sclerosis in Lithuania

The Role of Low-Level Laser Therapy in the Treatment of Multiple Sclerosis: A Review Study

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