Effects of Photobiomodulation on High Glucose Induced Oxidative Stress in Human Embryonic Skin Fibroblasts

Chen, Hongli; Sun, Shujie; Pan, Zhengxia; Tu, Mengru; Shi, Jia; Bai, Hua; Han, Zhibo; Yao, Jianquan

doi:10.1109/jstqe.2021.3054050

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…[18] Oxidative stress is very harmful to diabetic wound healing. [19,20] First, a great many of ROS promote the overexpression of matrix metalloproteinase (MMP), [21,22] and cause the imbalance between degradation and production of ECM to destroy skin tissues. ROS also have a destructive effect on healingrelated cells (fibroblast, endothelial cells, keratinocytes, etc.)…”

Section: Introductionmentioning

confidence: 99%

Bioactive Glasses‐Based Nanozymes Composite Macroporous Cryogel with Antioxidative, Antibacterial, and Pro‐Healing Properties for Diabetic Infected Wound Repair

Zhu,

Li,

Wang

et al. 2023

Adv Healthcare Materials

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The treatment for diabetic ulcers still remains a big clinic challenge owing to the adverse repair microenvironment of bacterial infection, oxidative imbalance, deficient blood vessels and low regenerative ability. Bioactive glasses (BGs) play an important role in the late stages of healing due to their ability to promote vascular network formation and collagen fiber deposition. However, infection and oxidative stress in the early form a terrible wound microenvironment by destroying cells and growth factors to badly inhibit wound healing. Therefore, it is critical to develop a material involved in regulating the whole healing phases. In this work, bioactive glasses‐based nanozymes (MnO2@PDA‐BGs) with antioxidation, antibacterial and pro‐healing abilities were synthesized by the redox deposition of MnO2 on mesoporous BGs. Afterwards, cryogel with the interconnected macropore structure was fabricated by the polymerization of methacrylate anhydride gelatin (GelMA) at ‐20 °C, which is conducive to substance exchange, vascular ingrowth and ECM deposition. MnO2@PDA‐BGs were loaded into the cryogel to obtain nanocomposite cryogel (MnO2@PDA‐BGs/Gel) with good SOD, CAT‐like activities to eliminate ROS, such as ·OH, H2O2 and ·O2−. Besides, MnO2@PDA‐BGs/Gel had intensive POD‐like activity under acidic condition and good NIR photothermal responsiveness to achieve excellent antibacterial performance. Cells experiments demonstrated that MnO2@PDA‐BGs/Gel recruited L929s and promoted their proliferation due to the good bioactivity of BGs. Furthermore, MnO2@PDA‐BGs/Gel eliminated intracellular overexpressed ROS and maintained the viability of L929s. Animal experiments confirmed that MnO2@PDA‐BGs/Gel promoted wound healing and avoided scarring by killing bacteria, reversing inflammation, promoting vascularization, and also improving the deposition of collagen III.This article is protected by copyright. All rights reserved

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Section: Introductionmentioning

confidence: 99%

Bioactive Glasses‐Based Nanozymes Composite Macroporous Cryogel with Antioxidative, Antibacterial, and Pro‐Healing Properties for Diabetic Infected Wound Repair

Zhu,

Li,

Wang

et al. 2023

Adv Healthcare Materials

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Bibliometric Analysis to Global Research Status Quo on Photobiomodulation

Liu,

Xia,

Wei

et al. 2023

Photobiomodulation, Photomedicine, and Laser Surgery

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Photobiomodulation: A Systematic Review of the Oncologic Safety of Low-Level Light Therapy for Aesthetic Skin Rejuvenation

Glass¹

2023

Aesthetic Surgery Journal

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Background Photobiomodulation (PBM) therapy is an increasingly popular modality for aesthetic skin rejuvenation. PBM induces genomic, proteomic and metabolomic processes within target cells but such manipulation of cell behavior has led to concerns about oncologic safety. Objectives This article presents a summary of the clinical and pre-clinical evidence for the oncologic safety of PBM for aesthetic skin rejuvenation. Methods A focused systematic review was performed, wherein safety data from clinical trials of PBM for skin rejuvenation was supplemented by analyses of in vitro data using cells derived from human skin and human neoplastic cells and in vivo data of tumors of the skin, oral cavity and breast. Results Within established parameters, red/near infrared light mainly enhances proliferation of healthy cells without a clear pattern of influence on cell viability. The same light parameters mainly reduce neoplastic cell proliferation and viability or else make no difference. Invasiveness potential (appraised by cell migration assays and/or differential gene expression) is equivocal. PBM does not induce dysplastic change in healthy cells. In vivo tumor models yield varied results with no clear pattern emerging. There are no relevant clinical trials data linking PBM with any significant adverse events including the finding of a new or recurrent malignancy. Conclusions Current clinical and pre-clinical evidence suggests that PBM is oncologically safe for skin rejuvenation and there is no evidence to support the proposition that it should be avoided by patients who have previously undergone treatment for cancer.

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Effects of Photobiomodulation on High Glucose Induced Oxidative Stress in Human Embryonic Skin Fibroblasts

Cited by 3 publications

References 32 publications

Bioactive Glasses‐Based Nanozymes Composite Macroporous Cryogel with Antioxidative, Antibacterial, and Pro‐Healing Properties for Diabetic Infected Wound Repair

Bioactive Glasses‐Based Nanozymes Composite Macroporous Cryogel with Antioxidative, Antibacterial, and Pro‐Healing Properties for Diabetic Infected Wound Repair

Bibliometric Analysis to Global Research Status Quo on Photobiomodulation

Photobiomodulation: A Systematic Review of the Oncologic Safety of Low-Level Light Therapy for Aesthetic Skin Rejuvenation

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