Effects of phosphate on drug solubility behavior of mixture ibuprofen and lidocaine

Enthalpy–Entropy Compensation in the Structure-Dependent Effect of Nonsteroidal Anti-inflammatory Drugs on the Aqueous Solubility of Diltiazem

“…In addition, for the NPX/DTZ, DCF/DTZ, and IDM/DTZ mixtures, the regression lines for NPX in the NPX/DTZ mixture and DCF in the DCF/DTZ Dissolution Enthalpy of Components in Mixtures of Acidic Drugs with LDC Previously, the dissolution of IBP in a mixture with LDC in 1/10 M phosphate/NaOH buffer (pH 6.8) was found to be exothermic. 24) As shown in Supplementary Fig. S4a, in the present study, the dissolution of LDC was exothermic in 1/40 M phosphate/NaOH buffer (pH 6.88).…”

“…These results correspond to those of our previous study regarding the exothermic dissolution of IBP in LDC solution in phosphate/NaOH buffer. 24) Thus, the dissolution behavior of IBP was altered in both the IBP/DTZ and IBP/LDC mixtures.…”

“…Although LDC enhances the aqueous solubility of IDM, LDC has recently been shown to suppress the aqueous solubility of IBP. 24) According to the analysis of van't Hoff's reaction isobar, the dissolution processes of neat IBP and neat LDC are endothermic and exothermic, respectively. However, the dissolution of an IBP/LDC mixture is an exothermic process.…”

“…In addition, as we have frequently used LDC as a representative basic drug, comparisons were made between the behaviors of LDC and DTZ. 16,18,19,[22][23][24] Conventionally, it has been considered that aqueous solubility and dissolution rate are improved by the formation of an ionic liquid, a eutectic mixture, or a deep eutectic solvent via weakly electrostatic or hydrophilic interactions between drugs. However, the results of this study indicated that the solubility of a mixture can be regulated by the thermodynamic order of the components in the mixture such as entropy.…”

Therapeutic Liquid Formulations Based on Low Transition Temperature Mixtures for the Incorporation of Anti-Inflammatory Drugs

“…Reported solubility values for the different NSAIDs vary in some cases to a great extent. Nonetheless, according to our experiments, the solubility obtained for ibuprofen in PBS was lower than those reported in the literature (2000 to 7300 mg/L) [ 54 , 55 , 56 , 57 ]. For indomethacin the value obtained was concordant with Ivanova et al (1150–3170 mg/L) [ 58 ] but much higher than that indicated by Cayman (50 mg/L) [ 59 ].…”