Effects of phosphate depletion on acid-base status in dogs

Schmidt, R

doi:10.1016/0026-0495(78)90138-5

Cited by 10 publications

(1 citation statement)

References 23 publications

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“…That would depend on persistent bone mobilization after 7 days of fasting in previously phos phate-depleted animals, something which was not assessed in the present studies. Al though there are conflicting reports regard ing the integrity of renal bicarbonate reab sorption in the phosphate-depleted dog [11,12], whole-kidney bicarbonate reabsorption is normal in rats which are phosphate-de pleted for 25-35 days, in the absence of rather extreme pharmacologic interventions [13], After more prolonged phosphate deple tion, metabolic acidosis does develop in the rat [14].…”

Section: Discussionmentioning

confidence: 99%

Interactions of Starvation and Selective Phosphorus Depletion on Renal Phosphate Reabsorption

Steele¹

1982

Kidney Blood Press Res

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Renal phosphate (Pi) wastage following 7 days of starvation was investigated in normal rats (HI-P) and others previously stabilized on a low phosphorus (LO-P) diet. In LO-P animals, P_i excretion increased after starvation, but was significantly less than in starved HI-P rats. After thyroparathyroidectomy, the increase in Pi excretion after parathyroid hormone (PTH) was significantly greater in nonacidotic starved HI-P rats than in LO-P animals. However, PTH elicited a 31-fold increase in P_i excretion in both of these groups. Starved LO-P and HI-P rats responded equivalently to dibutyryl cyclic AMP. The renal response to phosphate depletion normally promotes P_i conservation, but is attenuated markedly by 7 days of subsequent starvation. This results from at least partial restoration of phosphaturic responsiveness to PTH during starvation.

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Section: Discussionmentioning

confidence: 99%