1977
DOI: 10.1111/j.1528-1157.1977.tb04976.x
|View full text |Cite
|
Sign up to set email alerts
|

Effects of Phenytoin on the Cyclic Nucleotide System in the Motor Nerve Terminal

Abstract: The effects of phenytoin on the motor nerve terminal were evaluated on the in vivo cat soleus nerve muscle preparation. Phenytoin, 10 mg/kg, reduced the repetitive aftercharges in motor nerve endings due to tetanic conditioning. It also reduced the repetitive activity due to adenylate cyclase activation with NaF, or to exogeneous dibutyryl cyclic AMP. These effects of phenytoin could be reversed by administering theophylline, a phosphodiesterase inhibitor, or by increasing the extracellular concentration of ca… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

1980
1980
1990
1990

Publication Types

Select...
4
2

Relationship

1
5

Authors

Journals

citations
Cited by 14 publications
(1 citation statement)
references
References 29 publications
0
1
0
Order By: Relevance
“…These monitored antidromically conducted action potentials were recorded on magnetic tape for later analysis and photography. For details of the method for recording antidromic neural discharges, see Dretchen et al (1977).…”
Section: Neuromuscular Experimentsmentioning
confidence: 99%
“…These monitored antidromically conducted action potentials were recorded on magnetic tape for later analysis and photography. For details of the method for recording antidromic neural discharges, see Dretchen et al (1977).…”
Section: Neuromuscular Experimentsmentioning
confidence: 99%